Early Biomarkers in Hospitalized Patients as Predictors of Long-Term Post- COVID-19 Conditions: A One-Year Cohort Study DOI Creative Commons
Chithira V Nair,

K. Malavika,

Georg Gutjahr

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 4, 2023

Abstract Background Post-COVID-19 conditions represent a significant challenge in patient care, with symptoms persisting beyond three month’s post-recovery. This study aimed to evaluate the incidence of post-COVID-19 at one year and identify predictive biomarkers comorbidities for effective risk stratification. Methods A cohort 120 adult patients, including 50 intensive care 70 non-intensive was followed up two weeks, six one-year post-discharge using structured questionnaires. The integrated laboratory forecast PCC. Results median age participants 56 years, 40% having moderate severe comorbidities. post-recovery, 32.8% exhibited post COVID-19 conditions. most common were constitutional (16%), respiratory (8.4%), neuropsychiatric (2.5%). Bayesian network analysis indicated correlations between symptoms, rehospitalisation, C-reactive protein, lactate-dehydrogenase, ferritin, albumin. Conclusion highlights prolonged impact conditions, infection. It role specific such as albumin tailoring individual by advancing understanding prediction. Our findings support need further research refine these insights, which are pivotal ongoing patients aftermath COVID-19.

Language: Английский

Prevalence, predictors, and patient-reported outcomes of long COVID in hospitalized and non-hospitalized patients from the city of São Paulo, Brazil DOI Creative Commons
Daniel Tavares Malheiro, Sabrina Bernardez‐Pereira, Kauê Capellato Junqueira Parreira

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 22, 2024

Background Robust data comparing long COVID in hospitalized and non-hospitalized patients middle-income countries are limited. Methods A retrospective cohort study was conducted Brazil, including patients. Long diagnosed at 90-day follow-up using WHO criteria. Demographic clinical information, the depression screening scale (PHQ-2) day 30, compared between groups. If PHQ-2 score is 3 or greater, major depressive disorder likely. Logistic regression analysis identified predictors protective factors for COVID. Results total of 291 1,118 with COVID-19 were included. The prevalence 47.1% 49.5%, respectively. Multivariable logistic showed female sex (odds ratio [OR] = 4.50, 95% confidence interval (CI) 2.51–8.37), hypertension (OR 2.90, CI 1.52–5.69), > 6.50, 1.68–33.4) corticosteroid use during hospital stay 2.43, 1.20–5.04) as patients, while 2.52, 1.95–3.27) 3.88, 2.52–6.16) Conclusion prevalent both Positive 30 post-infection can predict Early helps health staff to identify a higher risk COVID, allowing an early diagnosis condition.

Language: Английский

Citations

6
Long COVID syndrome: An unfolding enigma DOI Open Access

Surendra Kumar Sharma,

Alladi Mohan, Vishwanath Upadhyay

et al.

The Indian Journal of Medical Research, Journal Year: 2024, Volume and Issue: 159, P. 585 - 600

Published: Sept. 7, 2024

Post-acute sequelae of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disease (COVID-19), called as long COVID syndrome, is a major global public health issue after recovery from COVID-19. The occurs in symptomatic patients irrespective illness severity. symptoms continue four wk and persist beyond three months. Risk factors for include older age, female gender, multiple co-morbidities including diabetes mellitus, prior chronic illnesses, hospitalized with disease, especially receiving assisted ventilation, high viral load, reactivation Epstein Barr (EB) virus human herpes 6 (HH6), circulating auto antibodies against various organs type I interferon. prevalence varies 10 to 20 per cent, most data have been reported high-income countries. Any system can get involved COVID. fatigue, cognition impairment, cough dyspnoea, anosmia, hair loss diarrhoea, among others. While there are no laboratory tests confirmation diagnosis, reduced complement C7 complexes at six months, two-gene biomarker FYN SARS-CoV-2 antisense ribonucleic acid (RNA) emerging potentially useful biomarkers There should be alternative explain symptoms. Vaccination early use oral antiviral nirmatrelvir within the first five days mild having risk progression help preventing Several clinical trials underway treatment results these eagerly awaited. Physical mental rehabilitation home, community level or hospital setting appropriate essential

Language: Английский

Citations

5
Early biomarkers in hospitalized patients as predictors of post-acute sequelae of SARS-CoV-2 infection: a one-year cohort study DOI Creative Commons
Chithira V Nair,

Malavika Krishnakumar,

Georg Gutjahr

et al.

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 24, 2025

Post-acute sequelae of SARS-CoV-2 infection (PASC) represent a significant challenge in patient care, with symptoms persisting beyond three month's post-recovery. This study aimed to evaluate the incidence PASC at one year post-COVID-19 and identify predictive biomarkers comorbidities for effective risk stratification. A cohort 120 adult patients, including 50 intensive care 70 non-intensive was followed up two weeks, six one-year post-discharge using structured questionnaires. The integrated laboratory forecast PASC. median age participants 56 years, 40% having moderate severe comorbidities. post-recovery, 32.8% exhibited post COVID-19 conditions. most common were constitutional (16%), respiratory (8.4%), neuropsychiatric (2.5%). Bayesian network analysis indicated correlations between symptoms, rehospitalisation, C-reactive protein, lactate-dehydrogenase, ferritin, albumin. highlights prolonged impact PASC, infection. It role specific such as albumin tailoring individual by advancing understanding prediction. Our findings support need further research refine these insights, which are pivotal ongoing patients aftermath COVID-19.

Language: Английский

Citations

0
Analyzing the Interplay between COVID-19 Viral Load, Inflammatory Markers, and Lymphocyte Subpopulations on the Development of Long COVID DOI Creative Commons
Andrea Rivera-Cavazos,

José Antonio Luviano-García,

Arnulfo Garza-Silva

et al.

Microorganisms, Journal Year: 2023, Volume and Issue: 11(9), P. 2241 - 2241

Published: Sept. 6, 2023

The global impact of the SARS-CoV-2 infection has been substantial, affecting millions people. Long COVID, characterized by persistent or recurrent symptoms after acute infection, reported in over 40% patients. Risk factors include age and female gender, various mechanisms, including chronic inflammation viral persistence, have implicated long COVID's pathogenesis. However, there are scarce studies which multiple inflammatory markers load analyzed simultaneously to determine how they predict for COVID at long-term follow-up. This study explores association between markers, load, lymphocyte subpopulation during hospitalized patients better understand risk this disease. longitudinal retrospective was conducted with COVID-19 northern Mexico. Inflammatory parameters, phase were analyzed, followed up depending on severity persistence (weekly monthly) assessed 1.5 years infection. 79 patients, among them, 41.8% presented symptoms, fatigue being most common (45.5%). Patients had higher levels hospitalization, NK cell also associated COVID. ICU admission linked development symptoms.

Language: Английский

Citations

3
SÍNDROME PÓS-COVID-19: uma revisão integrativa DOI Creative Commons

Monique Da Silva Brilhnante,

Carla Regina de Almeida Corrêa,

Magda de Mattos

et al.

Revista Enfermagem Atual In Derme, Journal Year: 2024, Volume and Issue: 98(1), P. e024286 - e024286

Published: March 24, 2024

Introdução: A síndrome pós-COVID-19 é definida como um conjunto de sintomas persistentes da doença aguda causada pelo vírus SARS-Cov-2 não atribuídas a outras causas. Essa condição clínica acomete uma parcela significativa população com impacto na sua qualidade vida e nos cuidados saúde. Objetivo: Identificar literatura sobre pós-COVID-19, descrever prevalência principais manifestações clínicas. Método: Trata-se revisão integrativa inclusão artigos acesso via Pubmed, Lilacs Scielo publicados entre janeiro 2022 julho 2023, os descritores sendo post-COVID-19/pós-COVID-19; long-COVID-19/COVID-19 longa, post-acute sequelae of COVID-19/sequelas aguda, prevalence/prevalência, clinical manifestations/manifestações Identificou-se 525 dos quais 26 foram analisados compuseram amostra Resultados: descrita variou 10% 93% estudos avaliaram pacientes em períodos que compreenderem 1 mês até 12 meses após infecção aguda. As clínicas no podem envolver múltiplos órgão afetar qualquer sistemas orgânicos. Fadiga, dispneia anosmia as alterações mais citadas literatura. Conclusão: variável acordo estudo, todavia, atinge infectados SARS-Cov-2. Diante variedade clínicos essencial o cuidado aos seja realizado por equipe multiprofissional Os serviços saúde devem estar capacitados para atuar diante desse problema mundial se perpetua período pós-pandêmico.

Citations

0
Análise das características clínicas e dos aspectos físicos da qualidade de vida no pós-COVID-19 DOI Creative Commons
Kassila Conceição Ferreira Santos, Letícia Silveira Goulart, Ricardo Alves de Olinda

et al.

Caderno Pedagógico, Journal Year: 2024, Volume and Issue: 21(4), P. e3693 - e3693

Published: April 11, 2024

OBJETIVO: Identificar as características clínicas e sua relação com os aspectos físicos da Qualidade de Vida (QV) em indivíduos após hospitalização por COVID-19. MÉTODO: Estudo transversal que foram hospitalizados COVID-19 Rondonópolis, MT. Aplicou-se um questionário para avaliar sociodemográficos clínicos. Foi utilizado o instrumento WHOQOL- BREF a análise QV, no qual avaliou-se facetas do domínio físico. Para associações entre variáveis escores QV utilizou-se teste T RESULTADOS: Foram incluídos 91 participantes estudo. A maioria relatou não necessitar tratamento domiciliar ou ambulatorial especializado (65,2%), desenvolveu comorbidades (61,9%) precisou fazer uso contínuo novos medicamentos (80%) mo pós-COVID-19. Um total 87 (95,6%) informaram apresentar sintomas persistentes e/ou desenvolvidos pós-COVID-19, mais frequentes cansaço fácil (62,0%; n=54) alteração na memória/concentração (58,6%; n=51). Os relataram desenvolvimento alguma comorbidade alta hospitalar apresentaram menor média nas sono repouso (p=0,017) dependência medicamento (p=0,025). declararam 3 clínicos pós-COVID-19 evidenciaram menores dor desconforto (p=0,0006), energia fadiga (p=0,0033), (p=0,0015), mobilidade (p=0,042), (p=0,012), atividade vida cotidiana (p=0,0004) capacidade trabalho (p=0,011). CONCLUSÕES: Comorbidades persistência pós-COIVD-19 impactaram negativamente físico WHOQOL-BREF. dados enfatizam necessidade acompanhamento longo prazo dos recuperados importância serviços saúde estarem capacitados prestar cuidado integral esta população.

Citations

0
Early Biomarkers in Hospitalized Patients as Predictors of Long-Term Post- COVID-19 Conditions: A One-Year Cohort Study DOI Creative Commons
Chithira V Nair,

K. Malavika,

Georg Gutjahr

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 4, 2023

Abstract Background Post-COVID-19 conditions represent a significant challenge in patient care, with symptoms persisting beyond three month’s post-recovery. This study aimed to evaluate the incidence of post-COVID-19 at one year and identify predictive biomarkers comorbidities for effective risk stratification. Methods A cohort 120 adult patients, including 50 intensive care 70 non-intensive was followed up two weeks, six one-year post-discharge using structured questionnaires. The integrated laboratory forecast PCC. Results median age participants 56 years, 40% having moderate severe comorbidities. post-recovery, 32.8% exhibited post COVID-19 conditions. most common were constitutional (16%), respiratory (8.4%), neuropsychiatric (2.5%). Bayesian network analysis indicated correlations between symptoms, rehospitalisation, C-reactive protein, lactate-dehydrogenase, ferritin, albumin. Conclusion highlights prolonged impact conditions, infection. It role specific such as albumin tailoring individual by advancing understanding prediction. Our findings support need further research refine these insights, which are pivotal ongoing patients aftermath COVID-19.

Language: Английский

Citations

0