Analysis of the prevalence and clinical features of respiratory syncytial virus infection in a pediatric hospital in Zhejiang Province from 2019 to 2023
Journal of Medical Virology,
Journal Year:
2024,
Volume and Issue:
96(6)
Published: June 1, 2024
The
aim
of
this
study
was
to
investigate
the
epidemiological
characteristics
respiratory
syncytial
virus
(RSV)
infections
in
children
Zhejiang
from
2019
2023.
Data
pediatric
patients
who
visited
Children's
Hospital
University
School
Medicine
for
RSV
infection
between
and
2023
were
analyzed.
Nasopharyngeal
swabs
collected
antigen
detection,
relevant
patient
information
collected.
Factors
such
as
age
A
total
673
094
specimens
included
2023,
with
a
rate
positive
4.74%
(31
929/673
094).
highest
10.82%,
recorded
2021,
while
remaining
years
had
approximately
3%-5%.
In
terms
seasonal
prevalence
characteristics,
2019,
2020,
2022
peaked
winter
months
at
8%
decreased
summer
months,
where
remained
0.5%.
contrast,
is
peak
period
incidence
2021
being
high
9%-12%.
Based
on
gender
age,
found
that
detection
higher
boys
than
girls
2019-2023.
2019-2022,
among
different
groups,
aged
0
<6
it
age.
above
6
<12
1-2
group,
gradual
decrease
over
3
Between
pattern
changed.
observed
Language: Английский
Genomic surveillance and evolutionary dynamics of influenza a virus in Sri Lanka
Virology Journal,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: Nov. 26, 2024
Abstract
Background
Influenza
A
has
been
named
as
a
priority
pathogen
by
the
WHO
due
to
potential
cause
pandemics.
Genomic
sequencing
of
influenza
strains
is
important
understand
evolution
and
also
select
appropriate
vaccines
be
used
in
different
seasons
Sri
Lanka.
Therefore,
we
sought
molecular
epidemiology
viruses
Western
Province
Lanka,
including
mutational
analysis
investigate
evolutionary
dynamics.
Methodology
total
349
individuals
presenting
with
fever
respiratory
symptoms
were
enrolled
this
study
from
November
2022
May
2024.
Nasopharyngeal
oropharyngeal
specimens
collected
screened
using
quantitative
PCR
detect
A,
B,
SARS-CoV-2.
Subtyping
genomic
was
carried
out
on
Oxford
Nanopore
Technology.
Results
detected
49
(14%)
patients,
B
20
(5.7%)
SARS-CoV-2
41
(11.7%).
Co-infections
observed
five
participants.
The
phylogenetic
assigned
H1N1
HA
gene
sequences
within
6B.1
A.5a.2a
clade.
2023
belonging
subclades
C.1,
C.1.2,
C.1.8,
while
2024
C.1.8
C.1.9.
H3N2
3
C.2a1b.2a.2a.1b
clade
subclade
G.1.1.2,
C.2a1b.2a.2a.3a.1
J.2.
K54Q,
A186T,
Q189E,
E224A,
R259K,
K308R,
I418V,
X215A
amino
acid
substitutions
seen
sequences.
additionally
exhibited
further
substitutions,
such
V47I,
I96T,
T120A,
A139D,
G339X,
K156X,
T278S.
Conclusion
In
first
characterize
which
showed
circulating
an
18-month
period.
As
Lankan
had
certain
mutations
unknown
significance,
it
would
continue
detailed
surveillance
Lanka
choose
most
suitable
for
population
timing
vaccine
administration.
Language: Английский
The Molecular Epidemiology of Respiratory Syncytial Virus in Ontario, Canada from 2022 – 2024 using a Custom Whole Genome Sequencing Assay and Analytics Package
Henry Wong,
No information about this author
Calvin Sjaarda,
No information about this author
Brittany Rand
No information about this author
et al.
Journal of Clinical Virology,
Journal Year:
2024,
Volume and Issue:
176, P. 105759 - 105759
Published: Dec. 16, 2024
Language: Английский
Risk and protective factors for severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infection among healthcare workers: A test-negative case–control study in Québec, Canada
Sara Carazo,
No information about this author
Jasmin Villeneuve,
No information about this author
Denis Laliberté
No information about this author
et al.
Infection Control and Hospital Epidemiology,
Journal Year:
2022,
Volume and Issue:
44(7), P. 1121 - 1130
Published: Sept. 9, 2022
In
Québec,
Canada,
we
evaluated
the
risk
of
severe
acute
respiratory
coronavirus
virus
2
(SARS-CoV-2)
infection
associated
with
(1)
demographic
and
employment
characteristics
among
healthcare
workers
(HCWs)
(2)
workplace
household
exposures
prevention
control
(IPC)
measures
patient-facing
HCWs.
Language: Английский
Genomic Surveillance and Evolutionary Dynamics of Influenza A Virus in Sri Lanka
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 23, 2024
Abstract
Background
Influenza
A
has
been
named
as
a
priority
pathogen
by
the
WHO
due
to
potential
cause
pandemics.
Genomic
sequencing
of
influenza
strains
is
important
understand
evolution
and
also
select
appropriate
vaccines
be
used
in
different
seasons
Sri
Lanka.
Therefore,
we
sought
molecular
epidemiology
viruses
Western
Province
Lanka,
including
mutational
analysis
investigate
evolutionary
dynamics.
Methodology
total
349
individuals
presenting
with
fever
respiratory
symptoms
were
enrolled
this
study
from
November
2022
May
2024.
Nasopharyngeal
oropharyngeal
specimens
collected
screened
using
quantitative
PCR
detect
A,
B,
SARS-CoV-2.
Subtyping
genomic
was
carried
out
on
Oxford
Nanopore
Technology.
Results
detected
49
(14
%)
patients,
B
20
(5.7%)
SARS-CoV-2
41
(11.7%).
Co-infections
observed
five
participants.
The
phylogenetic
assigned
H1N1
HA
gene
sequences
within
6B.1A.5a.2a
clade.
2023
belonging
subclades
C.1,
C.1.2,
C.1.8,
while
2024
C.1.8
C.1.9.
H3N2
3C.2a1b.2a.2a.1b
clade
subclade
G.1.1.2,
3C.2a1b.2a.2a.3a.1
J.2.
K54Q,
A186T,
Q189E,
E224A,
R259K,
K308R,
I418V,
X215A
amino
acid
substitutions
seen
sequences.
additionally
exhibited
further
substitutions,
such
V47I,
I96T,
T120A,
A139D,
G339X,
K156X,
T278S.
Conclusion
In
first
characterize
which
showed
circulating
an
18-month
period.
As
Lankan
had
certain
mutations
unknown
significance,
it
would
continue
detailed
surveillance
Lanka
choose
most
suitable
for
population
timing
vaccine
administration.
Language: Английский
The Molecular Epidemiology of Respiratory Syncytial Virus Using a Custom Whole Genome Sequencing Assay and Analytics Package
Henry Wong,
No information about this author
Calvin Sjaarda,
No information about this author
Nick Buchner
No information about this author
et al.
Published: Jan. 1, 2024
Language: Английский
Burden of Illness Associated with Respiratory Syncytial Virus, Influenza, and COVID-19 in Infants and Young Children in Ontario, Canada, 2018-2023: a Population-Based Canadian Immunization Research Network (CIRN) Study
Open Forum Infectious Diseases,
Journal Year:
2024,
Volume and Issue:
11(10)
Published: Sept. 27, 2024
Abstract
Background
As
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
transitions
to
endemicity
and
syncytial
virus
(RSV)
influenza
reestablish
their
seasonal
circulation
patterns,
understanding
comparative
burden
on
infants
children
can
guide
health
system
responses
funding
priorities.
Methods
This
was
a
population-based
cohort
study
of
aged
<5
years
in
Ontario,
Canada,
from
September
2018
August
2023
using
linked
administrative
databases.
Results
Seasonal
cohorts
comprised
731
838
763
660
children.
RSV-
influenza-related
hospital
admission
rates
immediately
decreased
March
2020.
In
2021–2022,
RSV-related
admissions
rebounded
but
remained
8%–11%
lower
than
prepandemic
seasons,
whereas
2022–2023
increased
105%–113%
versus
seasons
peak
occurred
November
December.
Influenza
did
not
rebound
until
2022–2023,
when
were
28%–37%
higher
seasons.
Coronavirus
disease
2019
(COVID-19)–related
low
2021–2022
across
all
age
groups
during
pandemic
By
contrast,
COVID-19-related
exceeded
by
30%–40%
45%
admissions,
except
among
<12
months
who
at
highest
risk.
There
no
distinct
pattern
for
COVID-19–related
the
study.
Conclusions
RSV
remains
major
cause
childhood
hospitalization.
Although
COVID-19
appears
be
receding,
its
as
it
established.
The
unprecedented
peaks
together
with
return
ongoing
SARS-CoV-2
transmission,
underscore
need
strengthen
systems
real-time
surveillance
proactively
prepare
critical
healthcare
scenarios.
Language: Английский
Genomic Surveillance and Evolutionary Dynamics of Influenza A Virus in Sri Lanka
Published: Oct. 17, 2024
Abstract
Background
Influenza
A
has
been
named
as
a
priority
pathogen
by
the
WHO
due
to
potential
cause
pandemics.
Genomic
sequencing
of
influenza
strains
is
important
understand
evolution
and
also
select
appropriate
vaccines
be
used
in
different
seasons
Sri
Lanka.
Therefore,
we
sought
molecular
epidemiology
viruses
Western
Province
Lanka,
including
mutational
analysis
investigate
evolutionary
dynamics.
Methods
total
349
individuals
presenting
with
fever
respiratory
symptoms
were
enrolled
this
study
from
November
2022
May
2024.
Nasopharyngeal
oropharyngeal
specimens
collected
screened
using
quantitative
PCR
detect
A,
B,
SARS-CoV-2.
Subtyping
genomic
was
carried
out
on
Oxford
Nanopore
Technology.
Results
detected
49
(14%)
patients,
B
20
(5.7%)
SARS-CoV-2
41
(11.7%).
Co-infections
observed
five
participants.
The
phylogenetic
assigned
H1N1
HA
gene
sequences
within
6B.1A.5a.2a
clade.
2023
belonging
subclades
C.1,
C.1.2,
C.1.8,
while
2024
C.1.8
C.1.9.
H3N2
3C.2a1b.2a.2a.1b
clade
subclade
G.1.1.2,
3C.2a1b.2a.2a.3a.1
J.2.
K54Q,
A186T,
Q189E,
E224A,
R259K,
K308R,
I418V,
X215A
amino
acid
substitutions
seen
sequences.
additionally
exhibited
further
substitutions,
such
V47I,
I96T,
T120A,
A139D,
G339X,
K156X,
T278S.
Conclusion
In
first
characterize
which
showed
circulating
an
18-month
period.
As
Lankan
had
certain
mutations
unknown
significance,
it
would
continue
detailed
surveillance
Lanka
choose
most
suitable
for
population
timing
vaccine
administration.
Language: Английский
A randomized controlled trial comparing epinephrine and dexamethasone to placebo in the treatment of infants with bronchiolitis: the Bronchiolitis in Infants Placebo versus Epinephrine and Dexamethasone (BIPED) study protocol.
Amy C. Plint,
No information about this author
Anna Heath,
No information about this author
Tremaine Rowe
No information about this author
et al.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 8, 2024
Abstract
Background
Bronchiolitis
exerts
a
significant
burden
of
illness
on
infants
worldwide
predominantly
due
to
need
for
hospitalization.
Currently
only
supportive
care
is
advised
by
national
guidelines
with
bronchiolitis.
There
evidence
that
treating
bronchiolitis
combination
inhaled
epinephrine
and
dexamethasone
may
reduce
hospital
admissions.
Synergy
between
beta-agonists
corticosteroids
recognized
in
asthma
management
basic
science
literature
demonstrates
co-administration
these
medications
enhances
each
other’s
effectiveness.
Objective
To
determine
if
treated
(delivered
metered
dose
inhaler
spacer
or
nebulizer)
the
emergency
department
2-day
course
oral
have
fewer
hospitalizations
(due
bronchiolitis)
over
7
days
compared
placebo.
Design
The
BIPED
study
(Bronchiolitis
Infants
Epinephrine
versus
Dexamethasone
Placebo)
randomized,
placebo-controlled,
observer,
investigator,
clinician,
patient
blinded
superiority
clinical
trial
being
conducted
12
departments
across
three
countries
(Canada,
New
Zealand,
Australia).
We
will
recruit
864
60
months
age
receive
either
(1)
two
treatments
(3
mg
via
nebulizer
625
mcg
spacer)
30
minutes
apart
simultaneous
(0.6
mg/kg,
maximum
10
mg)
repeated
at
24
hours
(2)
placebo
primary
outcome
admission
within
(168
hours)
enrolment.
Secondary
outcomes
include
during
enrolment,
all
cause
admissions
healthcare
provider
visits
21
use
Bayesian
approach
data
analysis
inference.
Discussion
Given
bronchiolitis,
there
urgent
confirm
therapy
effective.
Trial
registration
ClinicalTrials.gov:
NCT03567473
.
Registered
2018-06-13.
Protocol
version
CTO
1423,
dated
20
January
2023
Sponsor-Investigator
Dr.
Amy
C
Plint,
Children’s
Hospital
Eastern
Ontario,
Ottawa,
Canada
Sponsor
Ontario
Research
Institute,
Language: Английский