Clinical Significance of Neutralizing Antibodies in COVID-19: Implications for Disease Prognosis

Life, Journal Year: 2025, Volume and Issue: 15(3), P. 429 - 429

Published: March 8, 2025

The pathogenesis of COVID-19 highlights a complex relationship between disease severity and neutralizing antibodies (NAbs). We aimed to investigate the relationships among total NAb (tNAb) levels, presence potential neutralization (pNAbs), clinical outcomes patients. Patients aged ≥18 years diagnosed October 2021 September 2022 were grouped by symptom severity. Blood samples taken at two time points data on demographics, epidemiology, vaccination recorded. tNAbs pNAbs measured an enhanced chemiluminescence assay surrogate virus test, respectively. 68 52 patients analyzed. Twenty-six (38.2%) had severe infection. 28-day mortality rate was 16.2% (n = 11). tNAb levels in control blood (CBSs) significantly higher than those admission (ABSs) (p < 0.001). statistical analysis showed no pNAbs. Vaccinated ABSs CBSs 0.001 p 0.001, respectively). correlated with lower 0.026) milder course 0.041). Although these findings support correlation mortality, their seems be unrelated favorable outcomes.

Language: Английский

Editorial: Infectious Disease Epidemiology and Transmission Dynamics 2.0

Viruses, Journal Year: 2024, Volume and Issue: 16(8), P. 1223 - 1223

Published: July 31, 2024

This Special Issue includes six original articles and one review article, all reflecting the unified scientific research endeavors professional expertise for a shared objective, which were published between July 2023 November [...]

Language: Английский