Heliyon,
Journal Year:
2024,
Volume and Issue:
10(19), P. e38677 - e38677
Published: Sept. 28, 2024
Uncertainties,
defined
as
metacognitive
awareness
of
ignorance,
are
an
essential
part
medicine.
Consequently,
healthcare
professionals
(HCPs)
well
informal
caregivers
face
them
inevitably.
Depending
on
the
interpretation
uncertainties
and
existence
available
resources
to
cope
with
them,
might
have
serious
consequences.
Studies
showed
higher
burnout-rates
reduced
psychosocial
well-being
HCPs
caregivers.
Especially
rare
diseases
linked
a
variety
uncertainties,
knowledge
about
specific
is
often
limited
which
result
in
burden
both
groups.
This
review
aimed
at
summarizing
studies
dealing
HCPs'
caregivers'
context
diseases.
We
searched
five
databases
screened
11.236
records
for
title/abstract
105
full-text.
Finally,
24
were
subjected
quality
assessment
data
extraction
using
narrative
synthesis.
Five
focused
HCPs,
19
Results
clustered
existing
taxonomy
differentiating
three
categories
uncertainty
(scientific,
practical
personal)
issues,
specifying
particular
uncertain
situations
or
circumstances.
Only
included
investigated
perspective
indicating
research
gap
topic
within
this
group.
Reports
mostly
scientific
uncertainties.
Concerning
information
procurement
up
special
facet
Informal
reported
whole
scientific,
personal
leading
psychological
consequences
such
fear,
confusion
worry.
provides
overview
assigned
issues
experience
relation
can
be
used
development
trainings,
teach
effective
coping
strategies
when
offers
support.
Journal of Personalized Medicine,
Journal Year:
2024,
Volume and Issue:
14(6), P. 598 - 598
Published: June 4, 2024
Personalized
sleep
medicine
represents
a
transformative
shift
in
healthcare,
emphasizing
individualized
approaches
to
optimizing
health,
considering
the
bidirectional
relationship
between
and
health.
This
field
moves
beyond
conventional
methods,
tailoring
care
unique
physiological
psychological
needs
of
individuals
improve
quality
manage
disorders.
Key
this
approach
is
consideration
diverse
factors
like
genetic
predispositions,
lifestyle
habits,
environmental
factors,
underlying
health
conditions.
enables
more
accurate
diagnoses,
targeted
treatments,
proactive
management.
Technological
advancements
play
pivotal
role
field:
wearable
devices,
mobile
applications,
advanced
diagnostic
tools
collect
detailed
data
for
continuous
monitoring
analysis.
The
integration
machine
learning
artificial
intelligence
enhances
interpretation,
offering
personalized
treatment
plans
based
on
individual
profiles.
Moreover,
research
circadian
rhythms
physiology
advancing
our
understanding
sleep’s
impact
overall
next
generation
technology
will
integrate
seamlessly
with
IoT
smart
home
systems,
facilitating
holistic
environment
Telemedicine
virtual
healthcare
platforms
increase
accessibility
specialized
care,
especially
remote
areas.
Advancements
also
focus
integrating
various
sources
comprehensive
assessments
treatments.
Genomic
molecular
could
lead
breakthroughs
disorders,
informing
highly
plans.
Sophisticated
methods
stage
estimation,
including
techniques,
are
improving
precision.
Computational
models,
particularly
conditions
obstructive
apnea,
enabling
patient-specific
strategies.
future
likely
involve
cross-disciplinary
collaborations,
cognitive
behavioral
therapy
mental
interventions.
Public
awareness
education
about
approaches,
alongside
updated
regulatory
frameworks
security
privacy,
essential.
Longitudinal
studies
provide
insights
into
evolving
patterns,
further
refining
approaches.
In
conclusion,
revolutionizing
disorder
treatment,
leveraging
characteristics
technologies
improved
diagnosis,
towards
marks
significant
advancement
enhancing
life
those
Despite
the
potential
benefits
of
generative
Artificial
Intelligence
(genAI),
concerns
about
its
psy-chological
impact
on
medical
students,
especially
with
regard
to
job
displacement,
are
apparent.
This
pilot
study,
conducted
in
Jordan
during
July–August
2024,
aimed
examine
specific
fears,
anxieties,
mistrust,
and
ethical
students
could
harbor
towards
genAI.
Using
a
cross-sectional
survey
design,
data
were
collected
from
164
studying
across
various
academic
years,
employing
structured
self-administered
questionnaire
an
internally
consistent
FAME
scale—representing
Fear,
Anxiety,
Mistrust,
Ethics
comprising
12
items,
three
items
for
each
construct.
The
results
indicated
variable
levels
anxiety
genAI
among
participating
students:
34.1%
reported
no
role
their
future
careers
(n
=
56),
while
41.5%
slightly
anxious
61),
22.0%
somewhat
36),
2.4%
extremely
4).
Among
constructs,
Mistrust
was
most
agreed
upon
(mean:
12.35±2.78),
followed
by
construct
10.86±2.90),
Fear
9.49±3.53),
Anxiety
8.91±3.68).
Sex,
level,
Grade
Point
Average
(GPA)
did
not
significantly
affect
students’
perceptions
However,
there
notable
direct
association
between
general
elevated
scores
constructs
scale.
Prior
exposure
previous
use
modify
These
findings
highlighted
critical
need
refined
educational
strategies
address
integration
training.
demonstrated
pervasive
anxiety,
fear,
regarding
deployment
healthcare,
indicating
necessity
curriculum
modifi-cations
that
focus
specifically
these
areas.
Interventions
should
be
tailored
increase
familiarity
competency,
which
would
alleviate
apprehension
equip
physicians
engage
this
inevitable
technology
effectively.
study
also
importance
incorporating
discussions
into
courses
mistrust
human-centered
aspects
Conclusively,
calls
proactive
evolution
education
prepare
AI-driven
healthcare
practices
shortly
ensure
well-prepared,
confident,
ethically
informed
professional
interactions
technologies.
Frontiers in Oral Health,
Journal Year:
2025,
Volume and Issue:
6
Published: April 14, 2025
Technological
innovations
in
dentistry
are
revolutionizing
the
monitoring
and
management
of
oral
health.
This
perspective
article
critically
examines
rapid
expansion
remote
technologies—including
artificial
intelligence
(AI)-driven
diagnostics,
electronic
health
records
(EHR),
wearable
devices,
mobile
applications,
chatbots—and
discusses
their
ethical,
legal,
social
implications.
The
accelerated
adoption
these
digital
tools,
particularly
wake
COVID-19
pandemic,
has
enhanced
accessibility
to
care
while
simultaneously
raising
significant
concerns
regarding
patient
consent,
data
privacy,
algorithmic
biases.
We
review
current
applications
ranging
from
AI-assisted
detection
dental
pathologies
blockchain-enabled
transfer
within
EHR
systems,
highlighting
potential
for
improved
diagnostic
accuracy
risks
associated
with
over-reliance
on
assessments.
Furthermore,
we
underscore
challenges
posed
by
divide,
where
disparities
literacy
access
may
inadvertently
exacerbate
existing
socio-economic
inequalities.
calls
development
rigorous
implementation
ethical
frameworks
regulatory
guidelines
that
ensure
reliability,
transparency,
accountability
innovations.
By
integrating
multidisciplinary
insights,
our
discussion
aims
foster
a
balanced
approach
maximizes
clinical
benefits
emerging
technologies
safeguarding
autonomy
promoting
equitable
healthcare
delivery.
BACKGROUND
Neurological
disorders
affect
approximately
3
billion
people
globally,
yet
clinical
trial
success
is
often
hindered
by
poorly
chosen
outcome
measures,
impacting
design,
compliance,
and
interpretation.
Core
Outcome
Sets
(COS)
have
emerged
over
the
past
25
years
as
standardized
tools
to
enhance
selection,
ensuring
comparability
across
studies
reflecting
priorities
of
both
researchers
patients.
Despite
COS
initiatives
in
other
fields,
their
development
neurology
remains
limited,
leaving
many
trialists
without
disease-specific
guidance.
Given
common
themes
neurological
COS,
a
unified
framework—a
‘COS
COS’—could
support
selection
where
no
exists.
OBJECTIVE
This
study
(COS-Neuro)
uses
Artificial
Intelligence
(AI)
analyse
existing
identifying
shared
domains
develop
thematic
framework,
streamlining
creation
improving
design.
METHODS
COS-Neuro
was
developed
using
AI-assisted
framework
analysis,
followed
expert
review.
A
modified
6-step
analysis
used
pre-determined
codes:
1.
Dataset
Gathering
–
Data
from
COMET
database
collected
for
diseases
were
coded.
2.
Prompt
Design
&
Testing
LLMs
(ChatGPT
3.5,
Google
Gemini
1.5
Flash,
Meta
Llama-2-70b)
trialled,
prompts
refined
based
on
responses.
3.
Thematic
Analysis
categorised
into
core
areas.
4.
Human
Refinement
Experts
reviewed
LLM-generated
areas
selected
most
appropriate
5.
Clinical
Validation
validated
domains,
areas,
concepts.
streamlined
approach
integrated
AI
with
oversight
standardised
disorders.
RESULTS
With
assistance
LLMs,
particularly
ChatGPT,
robust
conceptual
112
COS.
Adapting
OMERACT
model,
4
concepts,
13
75
finalised
following
consensus
clinicians.
CONCLUSIONS
establishes
recommendations
project
provides
foundation
future
research
reference
trials
lacking
established
It
also
sets
precedent
qualitative
medicine,
successful
adaptation
highlighting
its
scalability
COS’
specialties.
BMC Nursing,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: April 29, 2025
Generative
artificial
intelligence
(GenAI)
has
emerged
as
a
powerful
tool
in
nursing
education,
offering
novel
ways
to
enhance
clinical
reasoning,
critical
thinking,
and
personalized
learning.
However,
questions
remain
regarding
the
ethical
use
of
AI-generated
outputs,
data
privacy
concerns,
limitations
recognizing
emotional
nuances.
This
study
aims
explore
how
students
utilize
GenAI
tools
develop
care
plans,
with
particular
focus
on
innovative
role
prompt
engineering.
By
identifying
both
challenges
opportunities,
it
seeks
provide
actionable
insights
into
seamlessly
integrating
education
while
safeguarding
humanistic
skills.
A
qualitative
design
was
adopted,
involving
semi-structured
interviews
third-year
undergraduate
at
single
institution.
Participants
worked
anonymized
cases
multiple
tools,
emphasizing
iterative
prompts
optimize
care-plan
outputs.
Data
were
analyzed
thematically
capture
detailed
perspectives
AI-facilitated
learning
considerations.
Findings
indicate
that
enhanced
efficiency
conceptual
clarity,
allowing
more
higher-order
thinking.
Prompt
engineering
significantly
improved
accuracy
contextual
relevance
plans.
expressed
concerns
about
incomplete
or
imprecise
responses,
GenAI's
limited
understanding,
risks
associated
sensitive
healthcare
data.
When
used
careful
refinement
evaluation,
viewed
valuable
supplement
rather
than
replacement
for
competencies.
highlights
transformative
potential
underscoring
importance
structured
safeguards.
balancing
technological
innovation
empathy,
communication,
cultural
sensitivity,
educators
can
harness
AI
deepen
reasoning
prepare
future
AI-enhanced
practice.
Further
research
across
diverse
settings
is
needed
validate
these
findings
refine
best
practices
curricula.
Not
applicable.
did
not
involve
trial.
Frontiers in Education,
Journal Year:
2025,
Volume and Issue:
10
Published: May 1, 2025
Background
In
the
recent
generative
artificial
intelligence
(genAI)
era,
health
sciences
students
(HSSs)
are
expected
to
face
challenges
regarding
their
future
roles
in
healthcare.
This
multinational
cross-sectional
study
aimed
confirm
validity
of
novel
FAME
scale
examining
themes
Fear,
Anxiety,
Mistrust,
and
Ethical
issues
about
genAI.
The
also
explored
extent
apprehension
among
HSSs
genAI
integration
into
careers.
Methods
was
based
on
a
self-administered
online
questionnaire
distributed
using
convenience
sampling.
survey
instrument
scale,
while
toward
assessed
through
modified
State-Trait
Anxiety
Inventory
(STAI).
Exploratory
confirmatory
factor
analyses
were
used
construct
scale.
Results
final
sample
comprised
587
mostly
from
Jordan
(31.3%),
Egypt
(17.9%),
Iraq
(17.2%),
Kuwait
(14.7%),
Saudi
Arabia
(13.5%).
Participants
included
studying
medicine
(35.8%),
pharmacy
(34.2%),
nursing
(10.7%),
dentistry
(9.5%),
medical
laboratory
(6.3%),
rehabilitation
(3.4%).
Factor
analysis
confirmed
reliability
Of
constructs,
Mistrust
scored
highest,
followed
by
Ethics.
participants
showed
generally
neutral
genAI,
with
mean
score
9.23
±
3.60.
multivariate
analysis,
significant
variations
observed
previous
ChatGPT
use,
faculty,
nationality,
expressing
highest
level
apprehension,
Kuwaiti
lowest.
Previous
use
correlated
lower
levels.
higher
agreement
Ethics
constructs
statistically
associations
apprehension.
Conclusion
revealed
notable
Arab
HSSs,
which
highlights
need
for
educational
curricula
that
blend
technological
proficiency
ethical
awareness.
Educational
strategies
tailored
discipline
culture
needed
ensure
job
security
competitiveness
an
AI-driven
future.
Academic Pathology,
Journal Year:
2025,
Volume and Issue:
12(1), P. 100166 - 100166
Published: Jan. 1, 2025
The
integration
of
artificial
intelligence
in
pathology
has
ignited
discussions
about
the
role
technology
diagnostics-whether
serves
as
a
tool
for
augmentation
or
risks
replacing
human
expertise.
This
manuscript
explores
intelligence's
evolving
contributions
to
pathology,
emphasizing
its
potential
capacity
enhance,
rather
than
eclipse,
pathologist's
role.
Through
historical
comparisons,
such
transition
from
analog
digital
radiology,
this
paper
highlights
how
technological
advancements
have
historically
expanded
professional
capabilities
without
diminishing
essential
element.
Current
applications
pathology-from
diagnostic
standardization
workflow
efficiency-demonstrate
augment
accuracy,
expedite
processes,
and
improve
consistency
across
institutions.
However,
challenges
remain
algorithmic
bias,
regulatory
oversight,
maintaining
interpretive
skills
among
pathologists.
discussion
underscores
importance
comprehensive
governance
frameworks,
educational
curricula,
public
engagement
initiatives
ensure
remains
collaborative
endeavor
that
empowers
professionals,
upholds
ethical
standards,
enhances
patient
outcomes.
ultimately
advocates
balanced
approach
where
expertise
work
concert
advance
future
medicine.
Algorithms,
Journal Year:
2025,
Volume and Issue:
18(5), P. 266 - 266
Published: May 4, 2025
Bioequivalence
assessment
of
highly
variable
drugs
(HVDs)
remains
a
significant
challenge,
as
the
application
scaled
approaches
requires
replicate
designs,
complex
statistical
analyses,
and
varies
between
regulatory
authorities
(e.g.,
FDA
EMA).
This
study
introduces
use
artificial
intelligence,
specifically
Wasserstein
Generative
Adversarial
Networks
(WGANs),
novel
approach
for
bioequivalence
studies
HVDs.
Monte
Carlo
simulations
were
conducted
to
evaluate
performance
WGANs
across
various
variability
levels,
population
sizes,
data
augmentation
scales
(2×
3×).
The
generated
tested
acceptance
using
both
EMA
approaches.
WGAN
approach,
even
applied
without
scaling,
consistently
outperformed
EMA/FDA
methods
by
effectively
reducing
required
sample
size.
Furthermore,
not
only
minimizes
size
needed
HVDs,
but
also
eliminates
need
complex,
costly,
time-consuming
designs
that
are
prone
high
dropout
rates.
demonstrates
with
3×
can
achieve
rates
exceeding
89%
all
criteria,
10
out
18
scenarios
reaching
100%,
highlighting
method
potential
transform
design
efficiency
studies.
is
foundational
step
in
utilizing
clear
new
era
evaluation
begin.