Investigating Parkinson’s disease risk across farming activities using data mining and large-scale administrative health data

npj Parkinson s Disease, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 8, 2025

Abstract The risk of Parkinson’s disease (PD) associated with farming has received considerable attention, in particular for pesticide exposure. However, data on PD specific activities is lacking. We aimed to explore whether exhibited a higher than others among the entire French farm manager (FM) population. A secondary analysis real-world administrative insurance claim and electronic health/medical records (TRACTOR project) was conducted estimate 26 using mining. cases were identified through chronic declarations antiparkinsonian drug claims. There 8845 1,088,561 FMs. highest-risk group included FMs engaged pig farming, cattle truck fruit arboriculture, crop mean hazard ratios (HRs) ranging from 1.22 1.67. lowest-risk all involving horses small animals, as well gardening, landscaping reforestation companies (mean HRs: 0.48–0.81). Our findings represent preliminary work that suggests potential involvement occupational factors related onset development. Future research focusing farmers high-risk will allow uncover by better characterizing exposome, which could improve surveillance farmers.

Language: Английский

Global research trends on the human exposome: a bibliometric analysis (2005–2024)

Environmental Science and Pollution Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 8, 2025

Abstract Exposome represents one of the most pressing issues in environmental science research field. However, a comprehensive summary worldwide human exposome is lacking. We aimed to explore bibliometric characteristics scientific publications on exposome. A analysis from 2005 December 2024 was conducted using Web Science accordance with PRISMA guidelines. Trends/hotspots were investigated keyword frequency, co-occurrence, and thematic map. Sex disparities terms citations examined. From 2024, 931 published 363 journals written by 4529 authors 72 countries. The number tripled during last 5 years. Publications females (51% as first 34% authors) cited fewer times (13,674) than males (22,361). Human studies mainly focused air pollution, metabolomics, chemicals (e.g., per- polyfluoroalkyl substances (PFAS), endocrine-disrupting chemicals, pesticides), early-life exposure, biomarkers, microbiome, omics, cancer, reproductive disorders. Social built environment factors, occupational multi-exposure, digital exposure screen use), climate change, late-life received less attention. Our results uncovered high-impact countries, institutions, journals, references, authors, key trends/hotspots. use technologies sensors, wearables) data artificial intelligence) has blossomed overcome challenges could provide valuable knowledge toward precision prevention. risk scores represent promising avenue.

Language: Английский