Osteonecrosis of the Femoral Head: treatment before the collapse. Experience with decompression and biological therapy DOI Creative Commons
Yuri Lara-Taranchenko,

Iñaki Mimendia,

Vanesa Ojeda

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Abstract INTRODUCTION Osteonecrosis is a disabling condition and one of the most frequent causes hip arthroplasty in young population. Early detection treatment stages prior to femoral head collapse are essential prevent progression conversion total (THA). The present study aims demonstrate results obtained patients with initial ONFH, treated decompression system that associates biologic therapy (platelet-rich plasma mesenchymal stem cells) (PERFUSE). METHODOLOGY: Retrospective unicentric which all ONFH necrotic area biological between May 2018 2023, were collected. Demographic data (age gender), risk factors for AVN, necrosis (Kerboul), ARCO classification, rate THA obtained. RESULTS 24 using PERFUSE system. mean age was 47.67 years old, follow-up 26.1 months. improvement modified Harris Hip Score (mHHS) 10.11 (from 70.79 80.56; p = 0.018). Patients who developed had worse mHHS scores. 6 (25%) progressed collapse, 2 (8.33%) converted probability collapse-free survival at 12 months 90.9% (SD 6.2; 95%CI, 79.5–100%), 18 it 85.2% 8.0; 70.9–100%), 65.7% 11.7; 46.3–93.2%). CONCLUSION Core bone aspirate marrow platelet-rich can enhances regeneration delays especially when implemented early-stage ONFH. In this sense, combining both, core support offer promising approach managing Despite encouraging outcomes, further research needed optimize protocols evaluate long-term efficacy.

Language: Английский

Advancements in 3D Printing Technologies for Personalized Treatment of Osteonecrosis of the Femoral Head DOI Creative Commons
Tingting Chen,

Lincong Luo,

Jiaying Li

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101531 - 101531

Published: Feb. 5, 2025

Three-dimensional (3D) printing technology has shown significant promise in the medical field, particularly orthopedics, prosthetics, tissue engineering, and pharmaceutical preparations. This review focuses on innovative application of 3D addressing challenges osteonecrosis femoral head (ONFH). Unlike traditional hip replacement surgery, which is often suboptimal for younger patients, offers precise localization necrotic areas ability to create personalized implants. By integrating advanced biomaterials, this a promising strategy approach early hip-preserving treatments. Additionally, 3D-printed bone engineering scaffolds can mimic natural environment, promoting regeneration vascularization. In future, potential extends combining with artificial intelligence optimizing treatment plans, developing materials enhanced bioactivity compatibility, translating these innovations from laboratory clinical practice. demonstrates how uniquely addresses critical ONFH treatment, including insufficient vascularization, poor mechanical stability, limited long-term success conventional therapies. introducing gradient porous scaffolds, bioactive material coatings, AI-assisted design, work outlines novel strategies improve interventions. These advancements not only enhance efficacy but also pave way findings into applications.

Language: Английский

Citations

1
Osteonecrosis of the femoral head: treatment before the collapse. Experience with decompression and biological therapy DOI
Yuri Lara-Taranchenko,

Iñaki Mimendia,

Víctor Barro

et al.

European Journal of Orthopaedic Surgery & Traumatology, Journal Year: 2025, Volume and Issue: 35(1)

Published: April 3, 2025

Language: Английский

Citations

0
Residual deformity after femoral neck fracture affects the location of osteonecrosis of the femoral head DOI Creative Commons
Masanori Nishi, Takashi Atsumi,

Yasushi Yoshikawa

et al.

Bone & Joint Open, Journal Year: 2024, Volume and Issue: 5(5), P. 394 - 400

Published: May 15, 2024

Aims The localization of necrotic areas has been reported to impact the prognosis and treatment strategy for osteonecrosis femoral head (ONFH). Anteroposterior area after a neck fracture (FNF) not properly investigated. We hypothesize that change weight loading direction on due residual posterior tilt caused by malunited FNF may affect location ONFH. investigate relationship between angle (PTA) anteroposterior using lateral hip radiographs. Methods Patients aged younger than 55 years diagnosed with ONFH were retrospectively reviewed. Overall, 65 hips (38 males 27 females; mean age 32.6 (SD 12.2)) met inclusion criteria. stage 1 or 4 ONFH, as per Association Research Circulation Osseous classification, excluded. ratios anterior viable articular surface calculated setting centre reference point. PTA was measured Palm’s method. association assessed Spearman’s rank correlation analysis (median 6.0° (interquartile range 3 11.5)). Results identified negative (rho −0.477; p = 0.001), no 0.229; 0.067) 0.204; 0.132). Conclusion Our results suggest could necrosis. Cite this article: Bone Jt Open 2024;5(5):394–400.

Language: Английский

Citations

1
Comparing Modified Light Bulb with Multiple Drilling Methods in Treating Non-Traumatic Femoral Head Osteonecrosis: A Cohort Study DOI Creative Commons
Ali Parsa,

H. Lal Dolatabadi,

Saeid Esmaeilian

et al.

Journal of Orthopaedic Reports, Journal Year: 2024, Volume and Issue: unknown, P. 100503 - 100503

Published: Oct. 1, 2024

Language: Английский

Citations

0
What non-arthroplasty options are viable for patients who have early-stage femoral head osteonecrosis? DOI
Wenbo Mu,

M. A. Mont,

Amjad Hossain

et al.

The Journal of Arthroplasty, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

0
Osteonecrosis of the Femoral Head: treatment before the collapse. Experience with decompression and biological therapy DOI Creative Commons
Yuri Lara-Taranchenko,

Iñaki Mimendia,

Vanesa Ojeda

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Abstract INTRODUCTION Osteonecrosis is a disabling condition and one of the most frequent causes hip arthroplasty in young population. Early detection treatment stages prior to femoral head collapse are essential prevent progression conversion total (THA). The present study aims demonstrate results obtained patients with initial ONFH, treated decompression system that associates biologic therapy (platelet-rich plasma mesenchymal stem cells) (PERFUSE). METHODOLOGY: Retrospective unicentric which all ONFH necrotic area biological between May 2018 2023, were collected. Demographic data (age gender), risk factors for AVN, necrosis (Kerboul), ARCO classification, rate THA obtained. RESULTS 24 using PERFUSE system. mean age was 47.67 years old, follow-up 26.1 months. improvement modified Harris Hip Score (mHHS) 10.11 (from 70.79 80.56; p = 0.018). Patients who developed had worse mHHS scores. 6 (25%) progressed collapse, 2 (8.33%) converted probability collapse-free survival at 12 months 90.9% (SD 6.2; 95%CI, 79.5–100%), 18 it 85.2% 8.0; 70.9–100%), 65.7% 11.7; 46.3–93.2%). CONCLUSION Core bone aspirate marrow platelet-rich can enhances regeneration delays especially when implemented early-stage ONFH. In this sense, combining both, core support offer promising approach managing Despite encouraging outcomes, further research needed optimize protocols evaluate long-term efficacy.

Language: Английский

Citations

0