The Pharmacological Efficacy of Baicalin in Inflammatory Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9317 - 9317

Published: May 26, 2023

Baicalin is one of the most abundant flavonoids found in dried roots Scutellaria baicalensis Georgi (SBG) belonging to genus Scutellaria. While baicalin demonstrated have anti-inflammatory, antiviral, antitumor, antibacterial, anticonvulsant, antioxidant, hepatoprotective, and neuroprotective effects, its low hydrophilicity lipophilicity limit bioavailability pharmacological functions. Therefore, an in-depth study baicalin’s pharmacokinetics contributes laying theoretical foundation for applied research disease treatment. In this view, physicochemical properties anti-inflammatory activity are summarized terms bioavailability, drug interaction, inflammatory conditions.

Language: Английский

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Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives

Cancers, Journal Year: 2023, Volume and Issue: 15(7), P. 2128 - 2128

Published: April 3, 2023

Despite significant therapeutic advancements for cancer, an atrocious global burden (for example, health and economic) radio- chemo-resistance limit their effectiveness result in unfavorable consequences. Natural compounds are generally considered safer than synthetic drugs, use cancer treatment alone, or combination with conventional therapies, is increasingly becoming accepted. Interesting outcomes from pre-clinical trials using Baicalein medicines have been reported, some of them also undergone clinical later stages. As a result, we investigated the prospects Baicalein, naturally occurring substance extracted stems Scutellaria baicalensis Georgi Oroxylum indicum Kurz, which targets wide range molecular changes that involved development. In other words, this review primarily driven by findings studies therapy several cell populations based on promising research. The modifications numerous signal transduction mechanisms transcriptional agents highlighted as major players Baicalein’s anti-malignant properties at micro level. These include AKT serine/threonine protein kinase B (AKT) well PI3K/Akt/mTOR, matrix metalloproteinases-2 & 9 (MMP-2 9), Wnt/-catenin, Poly(ADP-ribose) polymerase (PARP), Mitogen-activated (MAPK), NF-κB, Caspase-3/8/9, Smad4, Notch 1/Hes, Signal transducer activator transcription 3 (STAT3), Nuclear factor erythroid 2-related 2 (Nrf2)/Kelch-like ECH-associated protein-1 (Keap 1), Adenosine monophosphate-activated (AMPK), Src/Id1, ROS signaling, miR 183/ezrin, Sonic hedgehog (Shh) signaling cascades. promise anti-inflammatory to anti-apoptotic/anti-angiogenic/anti-metastatic medicinal element treating various malignancies its capability inhibit malignant stem cells, evidence synergistic effects, design nanomedicine-based drugs altogether supported data presented study.

Language: Английский

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Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Biomimetics, Journal Year: 2024, Volume and Issue: 9(3), P. 154 - 154

Published: March 1, 2024

The incidence of microbial infections in orthopedic prosthetic surgeries is a perennial problem that increases morbidity and mortality, representing one the major complications such medical interventions. emergence novel technologies, especially 3D printing, represents promising avenue development for reducing risk eventualities. There are already host biomaterials, suitable being tested antimicrobial properties when they coated with bioactive compounds, as antibiotics, or combined hydrogels antioxidant properties, chitosan metal nanoparticles, among others. materials discussed context this paper comprise beta-tricalcium phosphate (β-TCP), biphasic calcium (BCP), hydroxyapatite, lithium disilicate glass, polyetheretherketone (PEEK), poly(propylene fumarate) (PPF), poly(trimethylene carbonate) (PTMC), zirconia. While recent research results promising, further required to address increasing antibiotic resistance exhibited by several common pathogens, potential fungal infections, toxicity some nanoparticles. Other solutions, like incorporation phytochemicals, should also be explored. Incorporating artificial intelligence (AI) certain implants use AI against bacterial might represent viable solutions these problems. Finally, there legal considerations associated biomaterials widespread which must taken into account.

Language: Английский

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Exploring Synergistic Benefits and Clinical Efficacy of Turmeric in Management of Inflammatory and Chronic Diseases: A Traditional Chinese Medicine Based Review

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100572 - 100572

Published: Jan. 1, 2025

Language: Английский

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The Potential of Flavonoids and Flavonoid Metabolites in the Treatment of Neurodegenerative Pathology in Disorders of Cognitive Decline

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 663 - 663

Published: March 7, 2023

Flavonoids are a biodiverse family of dietary compounds that have antioxidant, anti-inflammatory, antiviral, and antibacterial cell protective profiles. They received considerable attention as potential therapeutic agents in biomedicine been widely used traditional complimentary medicine for generations. Such medical herbal formulations extremely complex mixtures many pharmacologically active provide outcome through network pharmacological effects complexity. Methods emerging to determine the components their targets decipher complexities how pharmacology provides such effects. The gut microbiome has important roles play generation bioactive flavonoid metabolites retaining or exceeding antioxidative anti-inflammatory properties intact and, some cases, new antitumor antineurodegenerative bioactivities. Certain food items identified with high prebiotic profiles suggesting neutraceutical supplementation may be beneficially employed preserve healthy population bacterial symbiont species minimize establishment harmful pathogenic organisms. Gut health is an consideration effecting overall wellbeing linked organ systems. Bioconversion generates can also transported by vagus nerve systemic circulation brain populations exert beneficial effect. This particularly number neurological disorders (autism, bipolar disorder, AD, PD) characterized on moods, resulting depression anxiety, impaired motor function, long-term cognitive decline. Native flavonoids alleviation inflammation tissues, however, concerns raised levels not achieved, thus allowing them display optimal Dietary manipulation vagal stimulation both yielded responses treatment autism spectrum disorders, depression, establishing route communication gut-brain axis established disease intervention. While native known penetrate blood–brain barrier, microbiome-generated (e.g., protocatechuic acid, urolithins, γ-valerolactones), which retain antioxidant potency addition promote mitochondrial cerebrovascular microcapillary should considered biotherapeutic agents. Studies warranted experimentally examine efficacy directly, they emerge novel options.

Language: Английский

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Virtual screening and library enumeration of new hydroxycinnamates based antioxidant compounds: A complete framework

Journal of Saudi Chemical Society, Journal Year: 2023, Volume and Issue: 27(4), P. 101670 - 101670

Published: June 7, 2023

Designing of molecules for drugs is important topic from many decades. The search new very hard, and it expensive process. Computer assisted framework can provide the fastest way to design screen drug-like compounds. In present work, a multidimensional approach introduced designing screening antioxidant Antioxidants play crucial role in ensuring that body's oxidizing reducing species are kept proper balance, minimizing oxidative stress. Machine learning models used predict activity. Three hydroxycinnamates selected as standard antioxidants. Similar compounds searched ChEMBL database using chemical structural similarity method. libraries generated evolutionary New also designed automatic decomposition construction building blocks. activity all predicted machine models. space envisioned t-distributed stochastic neighbor embedding (t-SNE) Best shortlisted, their synthetic accessibility further facilitate experimental chemists. between studied fingerprints heatmap.

Language: Английский

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Phytochemicals Controlling Enterohemorrhagic Escherichia coli (EHEC) Virulence—Current Knowledge of Their Mechanisms of Action

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 381 - 381

Published: Jan. 4, 2025

Enterohemorrhagic Escherichia coli (EHEC) is a common pathotype of E. that causes numerous outbreaks foodborne illnesses. EHEC zoonotic pathogen transmitted from animals to humans. Ruminants, particularly cattle, are considered important reservoirs for virulent strains. Humans can become infected with through the consumption contaminated food and water or direct contact O157:H7 one most commonly reported illnesses in developed countries. The formation attaching effacing (A/E) lesions on intestinal epithelium, combined Shiga toxin production, hallmark infection lead lethal hemolytic–uremic syndrome (HUS). For phage-dependent regulation antibiotic treatment contraindicated, as it may exacerbate limiting therapeutic options supportive care. In response this challenge growing threat resistance, phytochemicals have emerged promising antivirulence agents. These plant-derived compounds target bacterial virulence mechanisms without promoting resistance. Therefore, aim study summarize recent knowledge use targeting EHEC. We focused molecular basis their action, principal determinants

Language: Английский

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Neuroprotective effects of phytochemicals through autophagy modulation in ischemic stroke

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Language: Английский

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Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression

Neuroscience, Journal Year: 2025, Volume and Issue: 569, P. 161 - 183

Published: Feb. 7, 2025

Language: Английский

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The Therapeutic Potential of Baicalin and Baicalein in Breast Cancer: A Systematic Review of Mechanisms and Efficacy

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 181 - 181

Published: March 11, 2025

Cancer remains a leading cause of death globally, with breast cancer being the most commonly diagnosed in women. This systematic review focuses on therapeutic potential baicalin and baicalein, two bioactive flavonoids derived from Scutellaria baicalensis, treatment. These compounds exhibit anticancer properties through mechanisms such as apoptosis induction, cell cycle arrest, inhibition metastasis. Baicalin baicalein modulate key signaling pathways, including NF-κB, PI3K/AKT/mTOR, Wnt/β-catenin, have shown efficacy both vitro vivo models. Their synergy chemotherapy agents incorporation into nanotechnology-based delivery systems highlight opportunities to enhance outcomes. However, current evidence is predominantly preclinical, limited clinical trials validate their safety humans. Challenges poor bioavailability rapid metabolism also underscore need for advanced formulation strategies. synthesizes molecular mechanisms, efficacy, applications research.

Language: Английский

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