Adrenal insufficiency in severely wounded men with combat gunshot injury DOI Creative Commons
N. Yu. Seliukova, Катерина Місюра, Е.М. Khoroshun

et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Journal Year: 2025, Volume and Issue: 20(8), P. 573 - 579

Published: Jan. 4, 2025

War destroys normal life and is the main factor of human psychological physical vulnerability. The stress war most powerful pathogenic in emergence, detection exacerbation somatic, mental behavioral disorders. Trauma can affect functioning hypothalamus pituitary gland, as well hypothalamic-pituitary-adrenal axis. One these strong types gunshot injury and, consequently, surgical intervention resulting metabo­lic physiological disturbances. During stress, an excessive amount cortisol produced, but when body exhausted, level this hormone decreases, then adrenal insufficiency occurs. article considered secondary that develop a result after combat trauma with massive blood loss, which be objectively characterized acute male combatants. It important to pay attention recognition early prevention hypoglycemia insufficiency. So, continuous glucose monitoring should used. Although test quite safe, it desirable have simpler diagnostic marker obtained without administration adrenocorticotropic hormone. also recommended study serum, deficiency sex hormones. Measurement dehydroepiandrosterone sulfate included laboratory assessment hypothalamic-­pituitary-adrenal axis function. Dynamic measurements proven increase accuracy diagnosing Thus, cause non-specific symptoms person who has stress. Early testing based on clinical suspicion prevent further development crisis.

Language: Английский

Adrenal insufficiency in severely wounded men with combat gunshot injury DOI Creative Commons
N. Yu. Seliukova, Катерина Місюра, Е.М. Khoroshun

et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Journal Year: 2025, Volume and Issue: 20(8), P. 573 - 579

Published: Jan. 4, 2025

War destroys normal life and is the main factor of human psychological physical vulnerability. The stress war most powerful pathogenic in emergence, detection exacerbation somatic, mental behavioral disorders. Trauma can affect functioning hypothalamus pituitary gland, as well hypothalamic-pituitary-adrenal axis. One these strong types gunshot injury and, consequently, surgical intervention resulting metabo­lic physiological disturbances. During stress, an excessive amount cortisol produced, but when body exhausted, level this hormone decreases, then adrenal insufficiency occurs. article considered secondary that develop a result after combat trauma with massive blood loss, which be objectively characterized acute male combatants. It important to pay attention recognition early prevention hypoglycemia insufficiency. So, continuous glucose monitoring should used. Although test quite safe, it desirable have simpler diagnostic marker obtained without administration adrenocorticotropic hormone. also recommended study serum, deficiency sex hormones. Measurement dehydroepiandrosterone sulfate included laboratory assessment hypothalamic-­pituitary-adrenal axis function. Dynamic measurements proven increase accuracy diagnosing Thus, cause non-specific symptoms person who has stress. Early testing based on clinical suspicion prevent further development crisis.

Language: Английский

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