Post-traumatic stress disorder, diabetes mellitus, and alpha-lipoic acid
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine),
Journal Year:
2025,
Volume and Issue:
21(1), P. 82 - 94
Published: Feb. 23, 2025
Post-traumatic
stress
disorder
(PTSD)
is
a
prognostic
factor
for
the
development
of
metabolic
syndrome
(MetS),
type
2
diabetes
mellitus
(T2DM),
increases
risk
cardiometabolic
pathologies
and
neurodegenerative
diseases.
At
same
time,
T2DM
MetS
can
also
cause
major
neurosis-like
psychiatric
symptoms
characteristic
PTSD.
Their
influence
manifested
through
negative
effects
on
central
nervous
system,
in
particular
Oxidative
chronic
low-grade
inflammation
play
an
important
role
pathophysiology
PTSD,
MetS,
T2DM,
making
them
main
therapeutic
targets.
Targeted
oxidative
stress,
mitochondrial
metabolism
disorders,
use
antioxidants,
α-lipoic
acid
(ALA),
positively
affect
not
only
course
comorbidities
but
manifestations
In
vitro
vivo
studies
have
demonstrated
that
ALA
modulates
number
pathways
associated
with
stress.
addition,
results
clinical
trials
confirm
antioxidant
mechanism
action
patients
obesity,
1
2.
The
neuroprotective
activity
being
actively
studied
proving
promising
as
approach
treatment
PTSD
Despite
significant
potential
ALA,
its
application
limited
by
several
barriers.
particular,
lack
standardized
protocols,
well
detailed
assessment
effectiveness
alone.
pharmacokinetic
profile
remains
limited,
which
one
factors
hinder
use.
this
context,
there
are
certain
prospects
transportation
systems
based
nanoparticles,
potentially
solve
these
problems.
technologies
solid
lipid
nanoparticles
such
niosomes,
liposomes,
nanostructured
carriers
micelles
provide
possibility
local
or
systemic
ALA.
However,
further
preclinical
needed
to
definitively
determine
feasibility
search
was
conducted
Scopus,
Science
Direct
(from
Elsevier)
PubMed,
including
MEDLINE
databases.
keywords
used
were
“α-lipoic
acid”,
“post-traumatic
disorder”,
“diabetes
mellitus”,
“metabolic
syndrome”.
A
manual
bibliography
publications
identify
study
could
be
found
during
online
search.
Language: Английский
Disorders of circadian rhythms of heart rate variability in diabetic cardiac autonomic neuropathy: mechanisms and consequences
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine),
Journal Year:
2025,
Volume and Issue:
20(8), P. 549 - 558
Published: Jan. 4, 2025
Abnormalities
in
heart
rate
variability
(HRV)
may
increase
the
risk
of
cardiovascular
disease
over
next
six
years
from
4
to
10
%.
It
is
reported
that
probability
stroke
or
cardiac
death
can
be
immediately
reduced
by
chronobiologically
assessing
HRV
and
optimizing
timed
treatment
efficacy.
Physiological
activities
are
under
control
autonomic
nervous
system.
Damage
nerves
results
dysfunction
vascular
dynamics,
particularly
neuropathy
(CAN).
Autonomic
imbalance
sympathetic
(SNS)
parasympathetic
systems
(PSNS)
regulation
function
contributes
metabolic
abnormalities
significant
morbidity
mortality
for
individuals
with
diabetes
mellitus
(DM).
Misalignment
circadian
rhythms
has
been
evidenced
patients
DM,
there
a
close
relationship
between
alterations
neuroendocrine
sleep
architecture,
clock
oscillations,
glucose
metabolism,
function,
diurnal
profiles
blood
pressure
rate.
Metabolic
syndrome,
hypertension,
myocardial
infarction,
DM
characterized
increased
SNS
activity
decreased
PSNS
activity.
However,
type
2
had
decrease
both
explained
which
responsible
CAN
affects
fibers.
The
purpose
this
review
was
discuss
current
state
problem
rhythm
disorders,
HRV.
Particular
attention
paid
factors
diabetic
CAN;
insights
into
mechanisms
excess
associated
pathogenesis
possible
pathogenic
pathways
binding
atherosclerosis
progression;
genetic
epigenetic
HRV;
disorders.
search
conducted
Scopus,
Science
Direct
(from
Elsevier),
PubMed,
including
MEDLINE
databases.
keywords
used
were
mellitus,
neuropathy,
rhythms,
variability.
A
manual
bibliography
publications
identify
study
could
not
found
during
online
search.
Language: Английский
Vitamin B6, cardiovascular diseases, and diabetes mellitus
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine),
Journal Year:
2025,
Volume and Issue:
21(1), P. 66 - 76
Published: Feb. 23, 2025
Vitamin
B6
is
a
broad
term
for
six
water-soluble
vitamins
that
can
change
forms.
These
include
pyridoxal,
pyridoxine,
pyridoxamine,
and
their
5-phosphorylated
forms,
which
are
pyridoxal
5’-phosphate
(PLP),
pyridoxine
5’-phosphate,
pyridoxamine
5’-phosphate.
PLP
the
biologically
active
form
of
vitamin
B6.
It
works
as
coenzyme
in
many
enzymatic
processes
speed
up
body’s
most
important
metabolic
reactions,
including
synthesis,
conversion
degradation
amines
amino
acids,
supply
one-carbon
units,
transsulfuration,
synthesis
tetrapyrrole
compounds
polyamines.
also
has
big
impact
on
metabolism
homocysteine
biosynthesis
different
neurotransmitters.
inhibits
production
reactive
oxygen
species
advanced
glycation
end
products,
genotoxic
linked
to
aging
diabetes
mellitus
(DM),
so
it
an
antioxidant.
In
addition,
functions
modulator
transcription
factors,
affects
activity
number
enzymes,
bind
steroid
hormone
receptors,
playing
role
membrane
transport.
Researchers
have
reported
patients
with
type
2
DM
cardiovascular
disease
(CVD)
exhibit
lower
levels
B6,
whereas
taking
supplements
lowers
risk
its
vascular
complications.
We
still
don’t
fully
understand
mechanisms
underlying
relationship
between
DM.
Instead,
growing
body
evidence
suggests
may
protect
against
complications
through
scavenger
species.
deficiency
been
clinically
significant
diseases,
autism,
schizophrenia,
Alzheimer’s
disease,
Parkinson’s
epilepsy,
Down
syndrome,
DM,
cancer,
although
remain
largely
unclear.
The
purpose
this
review
was
discuss
specifics
CVD
mellitus,
well
analyze
new
trends
directions
future
research.
analysis
focused
biological
tryptophan
metabolism,
correlation
CVD,
diabetes,
DNA
damage
diabetes.
search
conducted
Scopus,
Science
Direct
(from
Elsevier)
PubMed,
MEDLINE
databases.
keywords
used
were
“vitamin
B6”,
“cardiovascular
disease”,
“diabetes
mellitus”.
A
manual
bibliography
publications
identify
study
results
could
not
be
found
during
online
search.
Language: Английский