Journal of Clinical Medicine,
Journal Year:
2023,
Volume and Issue:
12(21), P. 6919 - 6919
Published: Nov. 3, 2023
Pulse
wave
velocity
(PWV)
assessment
represents
a
simple
method
to
estimate
arterial
distensibility.
At
present,
carotid-femoral
PWV
(cf-PWV)
is
considered
the
gold
standard
in
non-invasive
evaluation
of
elastic
properties
aorta.
On
other
hand,
mechanical
muscular
arteries
can
be
evaluated
on
axillo-brachial-radia
axis
by
estimating
carotid-radial
(cr-PWV).
While
number
studies
have
addressed
these
issues
adults,
limited
information
available
respective
features
cf-PWV
and
cr-PWV
their
modulating
factors
children
adolescents
at
increased
cardiovascular
risk.
The
predominantly
(aorta)
(axillo-brachial-radial
axis)
were
pediatric
population
characterized
either
elevated
blood
pressure
(BP)
or
excess
body
weight,
main
affecting
values
individuals
investigated.
443
(median
age
11.5
years,
43.3%
females)
enrolled;
25%
had
BP
>90th
percentile
81%
weight.
significantly
lower
than
values:
median
(Q1-Q3)
=
4.8
m/s
(4.3-5.5)
5.8
(5.0-6.5),
respectively
(p
<
0.001).
pubertal
development
0.03),
systolic
diastolic
z-scores
0.002),
heart
rate
0.001),
waist-to-height
ratio
0.005)
associated
with
values.
No
significant
association
was
found
between
BMI
z-score
cf-PWV.
Predictors
high
(>95th
percentile)
(OR
1.07,
95%CI
1.04-1.10,
p
0.001)
1.06,
1.0-1.13,
0.04).
variables
related
0.01),
HOMA
index
0.02).
ratio.
Systolic
central
obesity
are
aortic
stiffness
In
contrast,
BP,
rate,
levels
insulin
resistance
appear
distensibility
upper
limb
vascular
district.
Transplantation,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 16, 2024
Children
requiring
kidney
replacement
therapy
experience
high
burden
of
cardiovascular
(CV)
disease
leading
to
increased
mortality.
Intima-media
thickness
(IMT)
indicating
atherosclerosis
is
a
validated
surrogate
marker
for
future
CV
events.
EClinicalMedicine,
Journal Year:
2024,
Volume and Issue:
74, P. 102708 - 102708
Published: July 3, 2024
Despite
significant
cardiovascular
(CV)
morbidity
in
children
on
dialysis
and
after
kidney
transplantation,
data
the
evolution
of
CV
damage
with
chronic
disease
(CKD)
approaching
replacement
therapy
(KRT)
is
unknown.
AJP Cell Physiology,
Journal Year:
2025,
Volume and Issue:
328(2), P. C467 - C482
Published: Jan. 7, 2025
As
a
hallmark
of
chronic
kidney
disease
(CKD),
arterial
stiffening
is
related
to
increased
vascular
inflammation
and
cardiovascular
morbidity,
whereas
the
underlying
mechanism
unclear.
The
study
demonstrates
that
stiffness
precedes
onset
inflammation,
matrix
stimulates
transdifferentiation
smooth
muscle
cells
(VSMCs)
an
inflammatory
phenotype
via
activating
Runx2-NLRP3
signaling,
which
provides
novel
insights
into
CKD-related
disorder
treatment.
Journal of the American Heart Association,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 26, 2025
Background
Carotid
intima‐media
thickness
(cIMT)
may
identify
early
alterations
in
the
vascular
phenotype
children
with
chronic
kidney
disease
(CKD).
Methods
and
Results
Investigation
of
longitudinal
changes
cIMT
SD
scores
(SDS)
670
patients
from
4C
Study
(Cardiovascular
Comorbidity
Children
With
CKD
Study),
aged
6
to
17
years,
stage
3
5
at
baseline.
The
trajectory
SDS
over
up
8
years
was
examined
using
a
mixed‐effects
model.
yearly
progression
rate
(β=0.20
[95%
CI,
0.13–0.28])
remained
positive
during
initial
4.5‐year
follow‐up
period
but
slowed
down
quadratically
increasing
observation
time
(β=−0.02
−0.03
−0.01]).
Risk
factors
for
increased
included
since
baseline,
younger
age,
higher
height
SDS,
female
sex,
elevated
diastolic
blood
pressure,
lower
serum
albumin,
not
estimated
glomerular
filtration
rate.
In
progressive
CKD,
albuminuria
additionally
associated
an
increase
SDS.
stable
phosphate
were
only
risk
identified
Annual
rates
change
pressure
positively
correlated
within
first
4.5
(for
systolic:
β=0.42
0.22–0.62];
diastolic:
β=1.56
1.01–2.11]).
Conclusions
results
show
significant
CKD.
Changes
are
suggesting
relevant
impact
modulation
on
Hypertension,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 8, 2025
BACKGROUND:
Office
blood
pressure
(BP)
trajectories
may
help
assess
hypertension
progression
and
the
effects
of
antihypertensive
treatment
in
children
with
chronic
kidney
disease.
METHODS:
Analysis
BP
slopes
320
patients
from
4C
study
(Cardiovascular
Comorbidity
Children
Chronic
Kidney
Disease)
cohort
disease
before
renal
replacement
therapy,
based
on
a
minimum
3
individual
observations
2
years
follow-up.
RESULTS:
At
enrollment,
70
(22%)
had
uncontrolled
or
untreated
hypertension,
130
(41%)
controlled
120
(37%)
normotension
without
treatment.
Antihypertensive
medication
was
prescribed
for
53%
at
baseline
initiated
added
91
(AHT-I
group,
28%)
during
Overall
SD
score
remained
stable
over
time
(β=−0.037±0.034,
P
=0.34
−0.029±0.348,
=0.093
per
year
systolic
diastolic
score).
In
AHT-I
scores
were
higher
decreased
significantly
follow-up
(−0.22±0.07,
<0.003
−0.12±0.05
year,
=0.01).
Only
8
(11%)
previously
untreated/uncontrolled
group
last
observation,
while
31
(44%)
Of
normotensive
baseline,
60%
40%
progressed
to
uncontrolled/untreated
(n=23,
19%)
(n=24,
20%)
hypertension.
CONCLUSIONS:
Although
overall
population
time,
patterns
management
showed
considerable
variability.
control
improved
intensified
therapy;
however,
significant
number
individuals
developed
new-onset
observation
period.
Pediatric Nephrology,
Journal Year:
2024,
Volume and Issue:
39(9), P. 2759 - 2772
Published: May 8, 2024
Abstract
Background
Dyslipidemia
is
an
important
and
modifiable
risk
factor
for
CVD
in
children
with
CKD.
Methods
In
a
cross-sectional
study
of
baseline
serum
lipid
levels
large
prospective
cohort
stage
3–5
(predialysis)
CKD,
frequencies
abnormal
types
dyslipidemia
were
analyzed
the
entire
subpopulations
defined
by
fasting
status
or
presence
nephrotic
range
proteinuria.
Associated
clinical
laboratory
characteristics
determined
multivariable
linear
regression
analysis.
Results
A
total
681
patients
aged
12.2
±
3.3
years
mean
eGFR
26.9
11.6
ml/min/1.73
m
2
included.
Kidney
diagnosis
was
classified
as
CAKUT
69%,
glomerulopathy
8.4%,
other
disorders
22.6%
patients.
Nephrotic
proteinuria
(defined
urinary
albumin/creatinine
ratio
>
1.1
g/g)
present
26.9%.
found
71.8%,
high
triglyceride
(TG)
most
common
abnormality
(54.7%).
Fasting
(38.9%)
had
no
effect
on
status.
Except
significant
increase
TG
more
advanced
not
significantly
different
between
CKD
stages.
Hypertriglyceridemia
associated
younger
age,
lower
eGFR,
shorter
duration
higher
body
mass
index
(BMI-SDS),
albumin,
diastolic
blood
pressure.
Conclusions
involving
all
fractions,
but
mainly
TG,
majority
irrespective
cardiovascular
factors.
Graphical
abstract
Current Hypertension Reports,
Journal Year:
2024,
Volume and Issue:
26(10), P. 389 - 398
Published: May 28, 2024
Cardiovascular
disease
is
the
most
common
cause
of
mortality
across
lifespan
children
with
chronic
kidney
(CKD).
Hypertension
a
and
important
contributor,
but
other
factors
such
as
obesity,
dyslipidemia
mineral
bone
play
role.
This
narrative
review
focusses
on
studies
published
in
past
five
years
that
have
investigated
hypertension
cardiovascular
risk
among
CKD.
JACC Asia,
Journal Year:
2023,
Volume and Issue:
4(6), P. 444 - 453
Published: Dec. 12, 2023
Previous
studies
on
the
direction
of
association
between
arterial
stiffness
(AS)
and
chronic
kidney
disease
(CKD)
were
inconsistent,
leaving
a
knowledge
gap
in
understanding
temporal
sequence
association.
