Ethnicity-specific associations between the promoter region G-308A polymorphism (rs1800629) of the TNF-α gene and the development of end-stage renal disease: An evidence-based meta-analysis and trial sequential analysis DOI Creative Commons
Suthiya Anumas, Amarit Tansawet, Pawin Numthavaj

et al.

Genetics and Molecular Biology, Journal Year: 2025, Volume and Issue: 48(1)

Published: Jan. 1, 2025

Tumor necrosis factor-alpha (TNF-α), is partly attributed to pathogenesis of end-stage renal disease (ESRD). Inconsistency reported associations between TNF-α G-308A polymorphism (rs1800629) and ESRD prompted a meta-analysis obtain more precise estimates. Eleven case-control studies from 11 articles were included. Pooled odds ratios (OR) 95% confidence intervals (95% CIs) estimated evaluate the association. Subgroup analysis was based on ethnicity (Caucasian Asian). Multiple comparisons Bonferroni-corrected. Trial sequential (TSA) implemented ascertain reliability results. Sensitivity analyses publication bias tests performed significant There no association (pa >0.05) in overall ethnic subgroup. Indians, three pool ORs < 0.01-0.03) showed increased susceptibility homozygous (OR, 6.57; CI, 1.45 29.75; pa = 0.01), recessive 6.75; 1.44 31.56; 0.02), codominant 2.06; 1.08 3.94; 0.03) models. TSA indicated robustness such Indian population. The main outcomes robust without evidence bias. This study are confined which susceptible up approximately 7 times.

Language: Английский

Very low urinary marinobufagenin excretion reflects a high risk of disease progression in non-advanced CKD DOI Creative Commons
Davide Bolignano, Marta Greco, Loredana Tripodi

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 3, 2025

Background Chronic kidney disease (CKD) has now reached pandemic proportions but risk prediction towards end-stage (ESKD) remains challenging. Kidney fibrosis is a key determinant in the transition from CKD to ESKD. In this prospective study, we investigated prognostic significance of urinary Marinobufagenin (uMBG), cardiotonic steroid with acknowledged pro-fibrotic activity, for stratifying progression individuals non-advanced renal disease. Methods After baseline uMBG measurements, 108 patients (eGFR 40.54 ± 17 mL/min/1.73 m 2 ) were prospectively followed up 24 months. The study (renal) endpoint was composite serum creatinine doubling, eGFR decline &gt;25% values, or ESKD requiring chronic replacement therapy. Results During follow-up (mean 21 months), 32.4% had progressive CKD. These displayed almost halved excretion as compared others (p &lt; 0.0001). At ROC analysis showed remarkable diagnostic capacity on (AUC 0.898) and ≤310 pmol/L (Best ROC-derived cut-off) significantly faster (Log-rank 57.9; p Restricted cubic splines fitting logistic Cox-regression analyses revealed that association between best described by curvilinear, inverse J-shaped trend, highest associated very low levels. This trend remained unaffected adjustment age, eGFR, h-proteinuria. Conclusion CKD, MBG reflects more sustained over time. Validation studies are needed generalize these findings larger heterogeneous cohorts.

Language: Английский

Citations

0
Association between weekend catch-up sleep and chronic kidney disease: insights from NHANES 2017–2020 DOI Creative Commons
Sheng Chen, Ting Zhang, Hongjun Gao

et al.

Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)

Published: Feb. 5, 2025

Objective This study aimed to explore the association between weekend catch-up sleep (WCS) and chronic kidney disease (CKD) in American adults.

Language: Английский

Citations

0
Toward practical implementation of predictive models: cost-effective thresholds in machine learning models for chronic kidney disease screening DOI
Yiwen Cao, Sze‐chuan Suen

IISE Transactions on Healthcare Systems Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: Feb. 17, 2025

Language: Английский

Citations

0
Impact of urinary tract infection requiring hospital admission on short-term, mid-term and long-term renal outcomes in adult CKD patients - a potentially modifiable factor for CKD progression DOI Creative Commons
Deng-Chi Yang,

Jo-Yen Chao,

Chih-Yen Hsiao

et al.

Journal of Infection and Public Health, Journal Year: 2025, Volume and Issue: 18(5), P. 102712 - 102712

Published: Feb. 20, 2025

Urinary tract infection (UTI) or acute pyelonephritis can lead to renal scarring and impact the subsequent function progression. The aims of this study were investigate changes in related UTI requiring hospital admission (UTI/HA) association between UTI/HA long-term outcomes patients with chronic kidney disease (CKD). This was a multicenter, retrospective observational study. Renal events before after CKD analyzed for short-term mid-term outcomes. A case-control multivariate logistic regression analysis used clinical characteristics risk (kidney replacement therapy death, KRT/death) adult patients. included 1062 patients, 340 KRT 76 deaths identified during median follow-up 105 months. Among 174 UTI/HA, 59 (33.9 %) had bacteremia, 90 (51.7 injury (AKI), one in-hospital mortality. There faster decline rate estimated glomerular filtration (eGFR) compared pre-UTI/HA period [median (IQR) 0.37 (0.17-0.72) versus 0.19 (0.06-0.36) ml/min/1.73 m2 per month, P < 0.0001]. incidence similar KRT/death non-dialysis groups. Multivariate showed that baseline eGFR, eGFR number significantly associated an increased KRT/death. highlights on It demonstrates high AKI but low mortality, accelerated deterioration following UTI/HA. Long-term influenced by progression rate, frequency admission. may be regarded as potentially modifiable factor However, there is need further isolate from pre-existing

Language: Английский

Citations

0
Ethnicity-specific associations between the promoter region G-308A polymorphism (rs1800629) of the TNF-α gene and the development of end-stage renal disease: An evidence-based meta-analysis and trial sequential analysis DOI Creative Commons
Suthiya Anumas, Amarit Tansawet, Pawin Numthavaj

et al.

Genetics and Molecular Biology, Journal Year: 2025, Volume and Issue: 48(1)

Published: Jan. 1, 2025

Tumor necrosis factor-alpha (TNF-α), is partly attributed to pathogenesis of end-stage renal disease (ESRD). Inconsistency reported associations between TNF-α G-308A polymorphism (rs1800629) and ESRD prompted a meta-analysis obtain more precise estimates. Eleven case-control studies from 11 articles were included. Pooled odds ratios (OR) 95% confidence intervals (95% CIs) estimated evaluate the association. Subgroup analysis was based on ethnicity (Caucasian Asian). Multiple comparisons Bonferroni-corrected. Trial sequential (TSA) implemented ascertain reliability results. Sensitivity analyses publication bias tests performed significant There no association (pa >0.05) in overall ethnic subgroup. Indians, three pool ORs < 0.01-0.03) showed increased susceptibility homozygous (OR, 6.57; CI, 1.45 29.75; pa = 0.01), recessive 6.75; 1.44 31.56; 0.02), codominant 2.06; 1.08 3.94; 0.03) models. TSA indicated robustness such Indian population. The main outcomes robust without evidence bias. This study are confined which susceptible up approximately 7 times.

Language: Английский

Citations

0