Sex-Specific Associations of Cardiovascular Risk Factors with Subclinical Cardiac Remodeling: A Magnetic Resonance Imaging Study DOI Creative Commons
Maya Verma,

Kate Lindsay,

Jiayi Ni

et al.

Canadian Journal of Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Cardiovascular disease (CVD) is the leading cause of death in women, yet sex-specific risk factor influences remain understudied. Cardiac magnetic resonance imaging (CMR) detects early remodeling via left ventricular mass-to-volume ratio (LVMV), a validated concentricity marker. This study examines sex differences association CV factors, diet, and cardiac remodeling. We analyzed 622 age-matched adults (51% female, mean age 50.8 ± 9.5) from Courtois Signature Program. LVMV was defined as LV systolic mass divided by end-diastolic volume. Alcohol sugar intake self-rated on Likert scale. Mann-Whitney U regression analyses assessed associations between factors LVMV. Hypertension present 20.6% males 17.4% females; diabetes 9.8% 6.0%. Males had higher triglycerides, alcohol/sugar intake, (0.92 0.20 vs. 0.77 0.18 g/ml). correlated with both sexes (males: ß=0.099, p<0.001; females: ß=0.078, p<0.05), while triglycerides (ß=0.032, p<0.05) alcohol (H=19.41, p<0.0001) were male-specific predictors. In females, significantly associated (ß=0.102, ß=0.062, p<0.05). impact differently sex. males, linked to showed stronger associations. These results underscore need for tailored cardiovascular prevention strategies that account metabolic lifestyle factors.

Language: Английский

Sex-Specific Associations of Cardiovascular Risk Factors with Subclinical Cardiac Remodeling: A Magnetic Resonance Imaging Study DOI Creative Commons
Maya Verma,

Kate Lindsay,

Jiayi Ni

et al.

Canadian Journal of Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Cardiovascular disease (CVD) is the leading cause of death in women, yet sex-specific risk factor influences remain understudied. Cardiac magnetic resonance imaging (CMR) detects early remodeling via left ventricular mass-to-volume ratio (LVMV), a validated concentricity marker. This study examines sex differences association CV factors, diet, and cardiac remodeling. We analyzed 622 age-matched adults (51% female, mean age 50.8 ± 9.5) from Courtois Signature Program. LVMV was defined as LV systolic mass divided by end-diastolic volume. Alcohol sugar intake self-rated on Likert scale. Mann-Whitney U regression analyses assessed associations between factors LVMV. Hypertension present 20.6% males 17.4% females; diabetes 9.8% 6.0%. Males had higher triglycerides, alcohol/sugar intake, (0.92 0.20 vs. 0.77 0.18 g/ml). correlated with both sexes (males: ß=0.099, p<0.001; females: ß=0.078, p<0.05), while triglycerides (ß=0.032, p<0.05) alcohol (H=19.41, p<0.0001) were male-specific predictors. In females, significantly associated (ß=0.102, ß=0.062, p<0.05). impact differently sex. males, linked to showed stronger associations. These results underscore need for tailored cardiovascular prevention strategies that account metabolic lifestyle factors.

Language: Английский

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