Waist circumference is a strong predictor of a positive outcome evaluated one year after sleeve gastrectomy DOI Creative Commons
Marietta Bracha, Alina Jaroch, Jakub Wojtasik

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Purpose Bariatric surgeries, such as laparoscopic sleeve gastrectomy (LSG), not only result in significant weight loss but also improve the inflammatory state obese patients. This study aimed to investigate effects of LSG on and inflammation status bariatric patients one year post-procedure. Materials Methods prospective cohort was conducted from September 2022 till May 2024. Fifty adults were enrolled for LSG. All underwent assessments body measurements, well levels interleukin-6 (IL-6), interleukin-10 (IL-10) at baseline, then 3 12 months post-surgery. Results Twelve post-surgery, measurements showed a reduction, with median excess (%EWL) 56.8%, indicating clinical success procedure. %EWL strong correlation waist circumference (R= -0.738, p < 0.00001). A logistic regression model indicated that reduction just centimeter initial increases likelihood positive outcome by 12%. Moreover, increase observed IL-10 (p 0.0001), simultaneously decrease IL-6 0.0001). Conclusions provides valuable evidence supporting benefits both reducing inflammation. Waist emerged predictor metabolic while increased signaled immunological changes.

Language: Английский

Modulation of mTOR Signaling in Cardiovascular Disease to Target Acute and Chronic Inflammation DOI Creative Commons
Madlen Kaldirim, Alexander Lang, Susanne Pfeiler

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2022, Volume and Issue: 9

Published: June 29, 2022

Inflammation is a key component in the pathogenesis of cardiovascular diseases causing significant burden morbidity and mortality worldwide. Recent research shows that mammalian target rapamycin (mTOR) signaling plays an important role general inflammation-driven mechanisms underpin disease. mTOR kinase acts prominently pathways govern essential cellular activities including growth, proliferation, motility, energy consumption, survival. Since development drugs targeting mTOR, there proven efficacy terms survival benefit cancer allograft rejection. This review presents current information concepts activity myocardial infarction atherosclerosis, two instances illness involving acute chronic inflammation. In experimental models, inhibition reduces infarct size, enhances functional remodeling, lowers overall atheroma. Aside from well-known effects inhibition, which are suppression growth metabolic activity, also impacts on specific leukocyte subpopulations inflammatory processes. Inflammatory cell abundance decreased due to lower migratory capacity, production chemoattractants cytokines, attenuated proliferation. contrast generally suppressed signals, anti-inflammatory types such as regulatory T cells reparative macrophages enriched activated, promoting resolution inflammation tissue regeneration. Nonetheless, given its involvement control major maintenance immune response, modification this system necessitates balanced time-limited approach. Overall, will focus advancements, prospects, limits regulating

Language: Английский

Citations

36
The Role of cGAS-STING in Age-Related Diseases from Mechanisms to Therapies DOI Creative Commons
Weitao Zheng, Dechao Feng, Xingyu Xiong

et al.

Aging and Disease, Journal Year: 2023, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2023

With aging, the incidence of age-related diseases increases. Hence, are inevitable. However, mechanisms by which aging leads to onset and progression remain unclear. It has been reported that inflammation is closely associated with cGAS-STING signaling pathway, can sense aberrant presence cytosolic DNA during induce an inflammatory response, important mediator in diseases. a better understanding structure molecular biology axis, numerous selective inhibitors agonists targeting pathway human have developed modulate responses. Here, we provide narrative review activity discuss its general In addition, outline treatments may constitute potential therapeutic alternative for

Language: Английский

Citations

19
Research progress on the active ingredients of traditional Chinese medicine in the intervention of atherosclerosis: A promising natural immunotherapeutic adjuvant DOI Open Access

Jinpeng Jing,

Chaojun Zhu, Rui Gong

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 159, P. 114201 - 114201

Published: Jan. 5, 2023

Atherosclerosis (AS) is a chronic inflammatory disease caused by disorders of lipid metabolism. Abnormal deposition low-density lipoproteins in the arterial wall stimulates activation immune cells, including adhesion and infiltration monocytes, proliferation differentiation macrophages lymphocytes, their functions. The complex interplay between cells coordinates balance pro- anti-inflammation plays key role progression AS. Therefore, targeting cell activity may lead to development more selective drugs with fewer side effects treat AS without compromising host defense mechanisms. At present, an increasing number studies have found that active ingredients traditional Chinese medicine (TCM) can regulate function multiple ways against AS, showing great potential for treatment promising clinical applications. In this paper, we review mechanisms action lesions targets and/or pathways regulation TCM promote understanding system interactions provide relevant basis use as natural adjuvants immunotherapy.

Language: Английский

Citations

14
Identification and Validation of Candidate Gene Module Along With Immune Cells Infiltration Patterns in Atherosclerosis Progression to Plaque Rupture via Transcriptome Analysis DOI Creative Commons
Jing Xu, Cheng Chen, Yuejin Yang

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2022, Volume and Issue: 9

Published: June 22, 2022

To explore the differentially expressed genes (DEGs) along with infiltrating immune cells landscape and their potential mechanisms in progression of atherosclerosis from onset to plaque rupture.In this study, three atherosclerosis-related microarray datasets were downloaded NCBI-GEO database. The gene set enrichment analysis (GSEA) was performed for interpreting biological insights expression data. CIBERSORTx algorithm applied infer relative proportions atherosclerotic samples. DEGs screened using R. protein interaction network constructed via STRING. cluster analyzed by Cytoscape software. Gene ontology (GO) geneontology.org. least absolute shrinkage selection operator (LASSO) logistic regression receiver operating characteristics (ROC) analyses build machine learning models differentiating status. Pearson correlation carried out illustrate relationship between cells. levels validated two external cohorts. Transcriptional factors drug-gene investigate promising targets intervention.Pathways related immunoinflammatory responses identified according GSEA analysis, detailed fractions compared early advanced atherosclerosis. Additionally, we 170 (|log2FC|≥1 adjusted p < 0.05). They mainly enriched GO terms relating inflammatory response innate response. A nine genes, such as ITGB2, C1QC, LY86, CTSS, C1QA, CSF1R, LAPTM5, VSIG4, CD163, found be significant, correlations calculated. also upregulated Moreover, C1QA ITGB2 may exert pathogenic functions entire process atherogenesis.We reanalyzed transcriptomic signature development rupture cell, well revealed new specific prospective investigation disease-associated dynamic molecular processes regulations

Language: Английский

Citations

19
Polydopamine nanoparticle-mediated mild photothermal therapy for inhibiting atherosclerotic plaque progression by regulating lipid metabolism of foam cells DOI Creative Commons

Shuangshuang Tu,

Wenzhi Ren,

Jinru Han

et al.

Regenerative Biomaterials, Journal Year: 2023, Volume and Issue: 10

Published: Jan. 1, 2023

Abstract Since apoptosis of foam, cells can induce plaque instability, reducing intracellular lipid content while protecting foam from is beneficial for the safe and efficient therapy atherosclerosis. In this study, osteopontin-coupled polydopamine (PDA-OPN) nanoparticles were synthesized applied to target mild photothermal (PTT) The results laser confocal microscopy indicate that PDA-OPN be specially recognized absorbed by cells. Under near-infrared irradiation, generated decreases accumulation but does not cell apoptosis. vivo treatments demonstrate PTT substantially reduce area improve stability upregulating expression fibrosis in ApoE−/− mice. Our findings reinforce nanoparticle-mediated inhibit atherosclerotic progression, which provides new insights developing effective treatment methods

Language: Английский

Citations

12
Role of inflammation and immune response in atherosclerosis: Mechanisms, modulations, and therapeutic targets DOI
Fang Liu, Yijun Wang, Jiayin Yu

et al.

Human Immunology, Journal Year: 2023, Volume and Issue: 84(9), P. 439 - 449

Published: June 21, 2023

Language: Английский

Citations

12
Waist Circumference Is a Strong Predictor of a Positive Outcome Evaluated One Year After Sleeve Gastrectomy DOI
Marietta Bracha, Alina Jaroch, Jakub Wojtasik

et al.

Obesity Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Language: Английский

Citations

0
Tetrahydropalmatine improves mitochondrial function in vascular smooth muscle cells of atherosclerosis in vitro by inhibiting Ras homolog gene family A/Rho-associated protein kinase-1 signaling pathway DOI Creative Commons
Ke Ding,

Qiying Bao,

Jiaqi He

et al.

Open Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 1, 2025

Tetrahydropalmatine (THP) regulates mitochondrial function in vascular smooth muscle cells (VSMCs) to prevent or alleviate atherosclerosis (AS), with unclear specific mechanism. AS models were constructed by oxidized low-density lipoprotein (ox-LDL)-treated VSMCs. Cell counting kit-8 for cell viability, wound scratch assay migration, and flow cytometry cycle, intracellular reactive oxygen species, membrane potential (MMP) performed. Malondialdehyde (MDA) superoxide dismutase (SOD) levels biochemical kits, consumption rate (OCR) seahorse apparatus, apoptosis terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining, apoptosis-related expression western blot detected. Ras homolog gene family A/Rho-associated protein kinase-1 (RhoA/ROCK1) measured ELISA. The RhoA agonist, U46619, was employed validate mechanism of THP. THP suppressed cycle progression migration whereas alleviating viability oxidative stress, as reduced MDA enhanced SOD ox-LDL-incubated protected higher MMP OCR values. Additionally, decreased TUNEL-positive cells, Bax, Caspase-3, RhoA, ROCK1, osteopontin expression, while increased Bcl-2 myosin heavy chain levels. Furthermore, U46619 intervention antagonized effects improved VSMCs inhibiting RhoA/ROCK1 signaling pathway.

Language: Английский

Citations

0
Mitigating effects of hydroxysafflor yellow a on atherosclerotic inflammatory responses based on flavonoid macromolecule compound: Inhibition of Piezo1-YAP/JNK protein pathway DOI
Chunxiao Zhang, Lei Zhang, Lei Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142961 - 142961

Published: April 1, 2025

Language: Английский

Citations

0
CAR‐T cell therapeutic avenue for fighting cardiac fibrosis: Roadblocks and perspectives DOI
Ahmed M. E. Abdalla, Miao Yu,

Ahmed Ibrahim Mohamed Ahmed

et al.

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(2)

Published: Feb. 20, 2024

Abstract Heart diseases remain the primary cause of human mortality in world. Although conventional therapeutic opportunities fail to halt or recover cardiac fibrosis, promising clinical results and efficacy engineered chimeric antigen receptor (CAR) T cell therapy show several advancements. However, current models CAR‐T cells need further improvement since are associated with triggering excessive inflammatory cytokines that directly affect functions. Thus, study highlights critical function heart immune tissue fibrosis repair. The also confirms as an emerging for treating explores roadblocks therapy, considers future outlooks research development.

Language: Английский

Citations

3