Waist circumference is a strong predictor of a positive outcome evaluated one year after sleeve gastrectomy DOI Creative Commons
Marietta Bracha, Alina Jaroch, Jakub Wojtasik

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Purpose Bariatric surgeries, such as laparoscopic sleeve gastrectomy (LSG), not only result in significant weight loss but also improve the inflammatory state obese patients. This study aimed to investigate effects of LSG on and inflammation status bariatric patients one year post-procedure. Materials Methods prospective cohort was conducted from September 2022 till May 2024. Fifty adults were enrolled for LSG. All underwent assessments body measurements, well levels interleukin-6 (IL-6), interleukin-10 (IL-10) at baseline, then 3 12 months post-surgery. Results Twelve post-surgery, measurements showed a reduction, with median excess (%EWL) 56.8%, indicating clinical success procedure. %EWL strong correlation waist circumference (R= -0.738, p < 0.00001). A logistic regression model indicated that reduction just centimeter initial increases likelihood positive outcome by 12%. Moreover, increase observed IL-10 (p 0.0001), simultaneously decrease IL-6 0.0001). Conclusions provides valuable evidence supporting benefits both reducing inflammation. Waist emerged predictor metabolic while increased signaled immunological changes.

Language: Английский

The Impact of Stem/Progenitor Cells on Lymphangiogenesis in Vascular Disease DOI Creative Commons

Rong Mou,

Kai Chen,

Pengwei Zhu

et al.

Cells, Journal Year: 2022, Volume and Issue: 11(24), P. 4056 - 4056

Published: Dec. 15, 2022

Lymphatic vessels, as the main tube network of fluid drainage and leukocyte transfer, are responsible for maintenance homeostasis pathological repairment. Recently, by using genetic lineage tracing single-cell RNA sequencing techniques, significant cognitive progress has been made about impact stem/progenitor cells during lymphangiogenesis. In embryonic stage, lymphatic is primarily formed through self-proliferation polarized-sprouting from lymph sacs. However, assembly also guarantees sustained growth lymphvasculogenesis to obtain entire function. addition, there abundant sources in postnatal tissues, including circulating progenitors, mesenchymal stem cells, adipose tissue which can directly differentiate into endothelial participate Specifically, recent reports indicated a novel function lymphangiogenesis transplant arteriosclerosis atherosclerosis. present review, we summarized latest evidence diversity incorporation vasculature both stages, with emphasis on development vascular diseases provide rational guidance future research.

Language: Английский

Citations

4
Treating Cardiovascular Disease in the Inflammatory Setting of Rheumatoid Arthritis: An Ongoing Challenge DOI Creative Commons

Saloni Godbole,

Jenny Lue Solomon,

Maryann Johnson

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1608 - 1608

Published: July 19, 2024

Despite progress in treating rheumatoid arthritis, this autoimmune disorder confers an increased risk of developing cardiovascular disease (CVD). Widely used screening protocols and current clinical guidelines are inadequate for the early detection CVD persons with arthritis. Traditional factors alone cannot be applied because they underestimate missing window opportunity prompt intervention to decrease morbidity mortality. The lipid profile is insufficient assess risk. This review delves into connection between systemic inflammation arthritis premature onset CVD. shared inflammatory immunologic pathways two diseases that result subclinical atherosclerosis disrupted cholesterol homeostasis examined. treatment armamentarium summarized, a particular focus on each medication's effect, as well mechanism action, risk-benefit profile, safety, cost. A approach patients proposed based available evidence. mortality gap non-rheumatoid populations due represents urgent research need fields cardiology rheumatology. Future areas, including assessment tools novel immunotherapeutic targets, highlighted.

Language: Английский

Citations

0
Research trends and hotspots of the applications of single-cell RNA sequencing in cardiovascular diseases: a bibliometric and visualized study DOI Open Access
Yue Yu, Juan Ye, Rubing Wang

et al.

Annals of Medicine and Surgery, Journal Year: 2024, Volume and Issue: 86(12), P. 7164 - 7177

Published: Oct. 25, 2024

Language: Английский

Citations

0
Combined injection of pristane and Bacillus Calmette-Guerin Vaccine successfully establishes a lupus model with atherosclerosis DOI

Chunru Jiang,

Zhenduo Zhu,

Yu Tai

et al.

Experimental Cell Research, Journal Year: 2024, Volume and Issue: 444(2), P. 114381 - 114381

Published: Dec. 13, 2024

Language: Английский

Citations

0
Waist circumference is a strong predictor of a positive outcome evaluated one year after sleeve gastrectomy DOI Creative Commons
Marietta Bracha, Alina Jaroch, Jakub Wojtasik

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Purpose Bariatric surgeries, such as laparoscopic sleeve gastrectomy (LSG), not only result in significant weight loss but also improve the inflammatory state obese patients. This study aimed to investigate effects of LSG on and inflammation status bariatric patients one year post-procedure. Materials Methods prospective cohort was conducted from September 2022 till May 2024. Fifty adults were enrolled for LSG. All underwent assessments body measurements, well levels interleukin-6 (IL-6), interleukin-10 (IL-10) at baseline, then 3 12 months post-surgery. Results Twelve post-surgery, measurements showed a reduction, with median excess (%EWL) 56.8%, indicating clinical success procedure. %EWL strong correlation waist circumference (R= -0.738, p < 0.00001). A logistic regression model indicated that reduction just centimeter initial increases likelihood positive outcome by 12%. Moreover, increase observed IL-10 (p 0.0001), simultaneously decrease IL-6 0.0001). Conclusions provides valuable evidence supporting benefits both reducing inflammation. Waist emerged predictor metabolic while increased signaled immunological changes.

Language: Английский

Citations

0