Journal of Asthma, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10
Published: Dec. 4, 2024
Introduction Asthma severe imposes important economic burden for health systems, especially with the incorporation of new drugs. Recently, tezepelumab has been approved to prevent exacerbations in patients. This study explores economically justifiable price preventing patients asthma.
Language: Английский
Allergy, Journal Year: 2025, Volume and Issue: unknown
Published: March 5, 2025
Emerging biologics that selectively target key cytokines present a promising therapeutic alternative for patients suffering from severe, uncontrollable chronic rhinosinusitis with nasal polyps (CRSwNP). Despite the limited availability of registered CRSwNP treatment in China, country is experiencing rapid development this field. It imperative to standardize application biologic agents management preparation their future integration into care pathway. The Rhinology Group, Chinese Society Otorhinolaryngology-Head and Neck Surgery; Medical Doctor Association Nasal Ocular Allergy have convened an expert panel consisting principal investigators experienced clinical trials CRSwNP. This was assembled discuss China. Additionally, latest findings on pathogenesis CRSwNP, mechanisms agents, efficacy safety were reviewed, special emphasis research evidence reached consensus several critical issues, including criteria prescription, course, evaluation perspective. position paper aims guide physicians use As our experience continues grow, will be further updated.
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1729 - 1729
Published: Feb. 18, 2025
Severe asthma (SA) is a chronic inflammatory condition affecting approximately 10% of asthmatic patients, and eosinophils are considered key pathogenetic actors in significant number patients. Biological therapies have been demonstrated to improve control by decreasing exacerbation rates reducing the use oral corticosteroids. In this context, phenotyping endotyping patients with SA essential for selecting most effective therapeutic approach. For purpose, biomarkers such as IgE, absolute blood eosinophil count, fractional exhaled nitric oxide (FeNO) crucial defining patient's profile. Their integration provides framework classifying into T2-high, T2-mild, or T2-low categories, guiding personalized treatment strategies. By incorporating multiple unified model, it possible better stratify optimize biologic therapy selection, paving way improved outcomes management. This review aims evaluate role particular attention impact eosinophilic inflammation combinatory on decision-making processes selection biological therapies.
Language: Английский
Citations
1
Expert Opinion on Pharmacotherapy, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 20
Published: Sept. 29, 2024
Chronic obstructive pulmonary disease (COPD) is a common syndrome associated with smoking and environmental exposures coupled genetic susceptibility. Recent major advancements in the treatment of COPD patients have become available.
Language: Английский
Citations
5
Cureus, Journal Year: 2025, Volume and Issue: unknown
Published: May 7, 2025
Language: Английский
Citations
0
Universidad Internacional de Andalucía eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 83 - 111
Published: April 1, 2024
Capítulo incluido en el libro: Estrategias prácticas para combatir las enfermedades alérgicas. Manuel Alcántara Villar (Coordinador). Sevilla: Universidad Internacional de Andalucía, 2024. ISBN 978-84-7993-414-9 (Edición PDF web). Enlace: http://hdl.handle.net/10334/8672
Citations
0
Universidad Internacional de Andalucía eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: April 1, 2024
Las enfermedades alérgicas se presentan como un desafío cada vez más relevante en la vida cotidiana de millones personas todo el mundo, ya que pueden manifestarse diversas formas, afectando nuestra calidad y generando incertidumbre preocupación. Su prevalencia ha experimentado notable aumento las últimas décadas, estimándose entre 10% 30% población mundial puede verse afectada por algún tipo alergia momento su vida. Aunque nuevas técnicas diagnosticas nuevos tratamientos campo alergología nos están ayudando a abordar estas con mayor precisión, nunca debemos olvidar historia clínica es una herramienta irremplazable diagnóstico alérgicas, proporciona información detallada sobre exposición desencadenantes alérgicos, los patrones síntomas, antecedentes médicos familiares, respuesta previos. Esta fundamental para desarrollar plan manejo efectivo personalizado paciente.
Citations
0
Microvascular Research, Journal Year: 2024, Volume and Issue: 155, P. 104714 - 104714
Published: July 1, 2024
Systemic sclerosis (SSc) is a complex autoimmune connective-tissue disease, characterised by vasculopathy and fibrosis of the skin internal organs. Activation microvascular endothelial cells (ECs) causes intimal hyperplasia that characterises vascular remodelling in SSc. The most frequent complication SSc development digital ulcers (DUs). Thymic stromal lymphopoietin (TSLP) may trigger sustain damage. Aim this study was to evaluate correlation between serum level TSLP DUs.
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 141, P. 112913 - 112913
Published: Aug. 12, 2024
Chronic respiratory diseases such as Obstructive Pulmonary Disease (COPD) and asthma have posed a significant healthcare economic cost over prolonged duration worldwide. At present, available treatments are limited to range of preventive medicines, mono- or multiple-drug therapy, which necessitates daily use not considered viable reverse the inflammatory processes airway remodelling is inclusive alteration intra extracellular matrix tract, death epithelial cells, increase in smooth muscle cell activation fibroblasts. Hence, with problem mind considerable body study has been dedicated comprehending underlying factors that contribute inflammation within framework these disorders. adequate literature unveiled necessary cellular probing reduce tract by improving selectivity precision novel treatment. However, through mechanisms downregulation various markers, interleukin 8, (IL-8), Interleukin 6 (IL-6), 1β (IL-1β) tumor necrosis factor-α (TNF-α) uncovered. target probes implementation phytoceuticals encapsulated an advanced drug delivery system shown potential be solution vitro vivo studies highlighting their anti-inflammatory antioxidant effects. high costs associated systems focused exclusively on nanoparticles pose challenges. Additionally, biochemical characteristics due poor solubility, bioavailability, difficulties mass production makes it difficult implement this product treatment for COPD asthma. This aims examine integration many critical features context application chronic
Language: Английский
Citations
0
Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 3, 2024
We report a case of 53-year-old male hairdresser with refractory asthma clinically diagnosed as eosinophilic granulomatosis polyangiitis (EGPA) who showed remarkable improvement tezepelumab after failing mepolizumab therapy. The patient presented three-year history progressive multisystem involvement, including anosmia, asthma, hearing loss, and skin rash. was EGPA based on sinusitis nasal polyps, eosinophilia, purpura. Despite initial oral corticosteroids mepolizumab, he experienced recurrent exacerbations asthma. Tezepelumab initiated, resulting in significant symptom improvement, successful corticosteroid tapering, marked enhancement pulmonary function tests. This suggests that may be an effective treatment option for patients particularly those suspected occupational exposure. Further research is needed to identify factors predict response different biologic therapies EGPA-related explore the potential role exposures outcomes.
Language: Английский
Citations
0
Tissue and Cell, Journal Year: 2024, Volume and Issue: 93, P. 102646 - 102646
Published: Nov. 30, 2024
Language: Английский
Citations
0