Nanoparticles
have
been
developed
to
overcome
the
limitation
of
free
therapeutics
and
enable
targeting
specific
sites
in
a
controlled
manner;
they
proven
be
effective
as
drug
carriers
diagnostic
tools.
Pulmonary
delivery
is
greatly
preferred
treatment
lung
diseases
has
its
advantages
over
other
routes
systemic
well.
However,
delivering
nanoparticles
hindered
by
their
physical
instability
poor
deposition
efficiency
due
particle-particle
interaction
low
inertia,
respectively.
Developing
inhalable
part
an
solid
state
dry
powder
combines
pulmonary
nanoparticle
systems
offers
unique
advantages.
Several
particle
engineering
techniques
utilized
combine
within
form
micron-scale
carrier
with
improved
handling
aerosolization
properties
ability
release
upon
lungs.
This
chapter
will
describe
different
classes
nano-in-micro
frameworks.
The
used
for
developing
these
frameworks
also
discussed.
Journal of Pharmaceutical Negative Results,
Journal Year:
2022,
Volume and Issue:
unknown, P. 595 - 605
Published: Oct. 22, 2022
The
present
study
aims
to
enhance
the
bioavailability
of
Blueberry
by
formulating
it
as
nanosuspension.
mainly
consists
ofanthocyanins
which
have
strong
antihyperlipidemic
activity
but
suffers
from
low
causes
hindrances
in
itstherapeutic
treat
hyperlipidemia.
Hence
improve
its
bioavailability,
nanosuspension
blueberry
was
prepared.
BoxBehnken
design
applied
predict
effect
independent
variables
namely
concentration
chitosan
and
oftripolyphosphate
(TPP)
stirring
speed
on
two
responses
particle
size
entrapment
efficiency.
suggested
thata
formulation
having
a
205.05nm
efficiency
76.60
%
will
be
an
optimized
if
haschitosan,
TPP,and
0.5%,
0.05%,and
1050
rpm
respectively.
prepared
itwas
found
that
198.5
nm
75.14±0.56
In
addition,
wasfound
polydispersity
index,
refractive
zeta
potential
0.351,
1.33,
21.08mv
respectively.SEM
analysis
showed
thedroplet
under
200nm.When
compared
towards
with
drug
extract
release
shows
controlled
releaseof
up
8
hrs
enhances
suspension
maximum
2hrs
whichshows
immediate
drug.
As
result,
our
research
nanotechnology
might
utilized
effective
approachincreasing
this
article
also
focuses
ofanthocyanin.
Nanoparticles
have
been
developed
to
overcome
the
limitation
of
free
therapeutics
and
enable
targeting
specific
sites
in
a
controlled
manner;
they
proven
be
effective
as
drug
carriers
diagnostic
tools.
Pulmonary
delivery
is
greatly
preferred
treatment
lung
diseases
has
its
advantages
over
other
routes
systemic
well.
However,
delivering
nanoparticles
hindered
by
their
physical
instability
poor
deposition
efficiency
due
particle-particle
interaction
low
inertia,
respectively.
Developing
inhalable
part
an
solid
state
dry
powder
combines
pulmonary
nanoparticle
systems
offers
unique
advantages.
Several
particle
engineering
techniques
utilized
combine
within
form
micron-scale
carrier
with
improved
handling
aerosolization
properties
ability
release
upon
lungs.
This
chapter
will
describe
different
classes
nano-in-micro
frameworks.
The
used
for
developing
these
frameworks
also
discussed.
