Advancements of metallic nanoparticles: A promising frontier in cancer treatment
Science Progress,
Journal Year:
2024,
Volume and Issue:
107(4)
Published: Oct. 1, 2024
The
incidence
of
cancer
is
increasing
and
evolving
as
a
major
source
mortality.
Nanotechnology
has
garnered
considerable
scientific
interest
in
recent
decades
can
offer
promising
solution
to
the
challenges
encountered
with
traditional
chemotherapy.
Nanoparticle
utilization
holds
promise
combating
other
diseases,
offering
exciting
prospects
for
drug
delivery
systems
medicinal
applications.
Metallic
nanoparticles
exhibit
remarkable
physical
chemical
properties,
such
their
minute
size,
composition,
structure,
extensive
surface
area,
rendering
them
versatile
cost-effective.
Research
demonstrated
significant
beneficial
impact
on
treatment,
characterized
by
enhanced
targeting
abilities,
gene
activity
suppression,
improved
efficiency.
By
incorporating
ligands,
functionalized
metal
ensure
precise
energy
deposition
within
tumors,
thereby
augmenting
treatment
accuracy.
Moreover,
beyond
therapeutic
efficacy,
serve
valuable
tools
cell
visualization,
contributing
diagnostic
techniques.
Utilizing
allows
simultaneous
diagnosis
while
also
facilitating
controlled
release,
thus
revolutionizing
care.
This
narrative
review
investigates
advancements
types
mechanisms
cells,
application
clinical
scenarios,
potential
toxicity
medicine.
Language: Английский
Pimozide-loaded nanostructured lipid carriers: Repurposing strategy against lung cancer
Wafa’ A. AL-Haj,
No information about this author
Hamdi Nsairat,
No information about this author
Mohamed El‐Tanani
No information about this author
et al.
Science Progress,
Journal Year:
2024,
Volume and Issue:
107(4)
Published: Oct. 1, 2024
Objective
This
study
aimed
to
repurpose
pimozide
(PMZ)
by
incorporating
it
into
nanostructured
lipid
carriers
(NLC)
using
a
modified
melting
emulsion
ultrasonication
method.
Methods
We
employed
stearic
and
oleic
acids
in
1:1
ratio
as
lipids,
with
Tween
80
PEG
4000
surfactants.
The
formulation
was
analyzed
for
particle
size,
zeta
potential,
encapsulation
efficiency.
Transmission
electron
microscopy
(TEM)
used
confirm
the
spherical
shape
of
particles.
release
profile
PMZ-NLC
evaluated
under
different
pH
conditions,
anticancer
activity
tested
on
A549
cell
lines.
Results
exhibited
an
average
size
136
±
2.9
nm,
potential
−25.1
0.9
mV,
efficiency
86%
11.
TEM
confirmed
NLCs.
PMZ
from
pH-sensitive,
enhancing
tumor
targeting.
IC
50
values
were
16.5
μM
free
12.9
after
72
h.
Discussion
demonstrated
improved
compared
PMZ,
suggesting
that
enhances
drug's
effectiveness.
pH-sensitive
supports
its
targeted
therapy
lung
cancer.
Conclusions
showed
safe
effective
strategy
cancer
treatment.
Further
investigation
is
warranted
evaluate
vivo
efficacy,
long-term
safety,
clinical
application.
Language: Английский
In vitro evaluation of lipidic nanocarriers for mebendazole delivery to improve anticancer activity
Maria‐Luisa Tamma,
No information about this author
Hamdi Nsairat,
No information about this author
Mohamed El‐Tanani
No information about this author
et al.
Drug Development and Industrial Pharmacy,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 10
Published: Nov. 11, 2024
Enhance
the
anticancer
activity
of
repurposed
drug
Mebendazole
(MBZ)
against
A549
cell
lines
by
developing
nanostructured
lipid
carriers
(NLCs).
Language: Английский
Green synthesized Zingiber officinale -ZnO nanoparticles: anticancer efficacy against 3D breast cancer model
Future Science OA,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: Nov. 14, 2024
Methodology:
Physical
characterization
and
biological
activity
were
performed
against
2D,
3D
spheroids
MCF-7
cell
lines.
Language: Английский