Green synthesized Zingiber officinale -ZnO nanoparticles: anticancer efficacy against 3D breast cancer model DOI Creative Commons

Ruqaya Alhaddad,

Bassam M. Abualsoud, Ibrahim Al‐Deeb

et al.

Future Science OA, Journal Year: 2024, Volume and Issue: 10(1)

Published: Nov. 14, 2024

Methodology: Physical characterization and biological activity were performed against 2D, 3D spheroids MCF-7 cell lines.

Language: Английский

Advancements of metallic nanoparticles: A promising frontier in cancer treatment DOI Creative Commons
Ali Al‐Samydai, Maha N. Abu Hajleh,

Farah Al-Sahlawi

et al.

Science Progress, Journal Year: 2024, Volume and Issue: 107(4)

Published: Oct. 1, 2024

The incidence of cancer is increasing and evolving as a major source mortality. Nanotechnology has garnered considerable scientific interest in recent decades can offer promising solution to the challenges encountered with traditional chemotherapy. Nanoparticle utilization holds promise combating other diseases, offering exciting prospects for drug delivery systems medicinal applications. Metallic nanoparticles exhibit remarkable physical chemical properties, such their minute size, composition, structure, extensive surface area, rendering them versatile cost-effective. Research demonstrated significant beneficial impact on treatment, characterized by enhanced targeting abilities, gene activity suppression, improved efficiency. By incorporating ligands, functionalized metal ensure precise energy deposition within tumors, thereby augmenting treatment accuracy. Moreover, beyond therapeutic efficacy, serve valuable tools cell visualization, contributing diagnostic techniques. Utilizing allows simultaneous diagnosis while also facilitating controlled release, thus revolutionizing care. This narrative review investigates advancements types mechanisms cells, application clinical scenarios, potential toxicity medicine.

Language: Английский

Citations

11

Pimozide-loaded nanostructured lipid carriers: Repurposing strategy against lung cancer DOI Creative Commons

Wafa’ A. AL-Haj,

Hamdi Nsairat, Mohamed El‐Tanani

et al.

Science Progress, Journal Year: 2024, Volume and Issue: 107(4)

Published: Oct. 1, 2024

Objective This study aimed to repurpose pimozide (PMZ) by incorporating it into nanostructured lipid carriers (NLC) using a modified melting emulsion ultrasonication method. Methods We employed stearic and oleic acids in 1:1 ratio as lipids, with Tween 80 PEG 4000 surfactants. The formulation was analyzed for particle size, zeta potential, encapsulation efficiency. Transmission electron microscopy (TEM) used confirm the spherical shape of particles. release profile PMZ-NLC evaluated under different pH conditions, anticancer activity tested on A549 cell lines. Results exhibited an average size 136 ± 2.9 nm, potential −25.1 0.9 mV, efficiency 86% 11. TEM confirmed NLCs. PMZ from pH-sensitive, enhancing tumor targeting. IC 50 values were 16.5 μM free 12.9 after 72 h. Discussion demonstrated improved compared PMZ, suggesting that enhances drug's effectiveness. pH-sensitive supports its targeted therapy lung cancer. Conclusions showed safe effective strategy cancer treatment. Further investigation is warranted evaluate vivo efficacy, long-term safety, clinical application.

Language: Английский

Citations

1

In vitro evaluation of lipidic nanocarriers for mebendazole delivery to improve anticancer activity DOI

Maria‐Luisa Tamma,

Hamdi Nsairat, Mohamed El‐Tanani

et al.

Drug Development and Industrial Pharmacy, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10

Published: Nov. 11, 2024

Enhance the anticancer activity of repurposed drug Mebendazole (MBZ) against A549 cell lines by developing nanostructured lipid carriers (NLCs).

Language: Английский

Citations

1

Green synthesized Zingiber officinale -ZnO nanoparticles: anticancer efficacy against 3D breast cancer model DOI Creative Commons

Ruqaya Alhaddad,

Bassam M. Abualsoud, Ibrahim Al‐Deeb

et al.

Future Science OA, Journal Year: 2024, Volume and Issue: 10(1)

Published: Nov. 14, 2024

Methodology: Physical characterization and biological activity were performed against 2D, 3D spheroids MCF-7 cell lines.

Language: Английский

Citations

1