Iron Overload in HIV: Clinical Challenges and Management Approaches
International Journal of Medical Sciences and Pharma Research,
Journal Year:
2024,
Volume and Issue:
10(2), P. 31 - 35
Published: July 15, 2024
Iron
overload
in
HIV-infected
individuals
represents
a
critical
but
often
under-recognized
challenge
that
impacts
disease
progression
and
patient
management.
The
interplay
between
iron
metabolism
HIV
infection
is
complex,
with
excess
exacerbating
oxidative
stress,
enhancing
viral
replication,
contributing
to
immune
dysfunction.
This
review
explores
the
clinical
implications
of
patients,
detailing
how
dysregulation
can
influence
outcomes
complicate
treatment
strategies.
Key
challenges
managing
include
accurate
diagnosis,
balancing
therapeutic
interventions,
addressing
co-infections.
Diagnostic
difficulties
arise
from
distinguishing
other
forms
anemia,
while
must
navigate
dual
issues
optimizing
antiretroviral
therapy
(ART).
Additionally,
co-infections
such
as
hepatitis
further
management
its
associated
liver
damage.
Current
strategies
involve
regular
monitoring
levels,
utilizing
phlebotomy
or
chelation
therapy,
ART
regimens
mitigate
their
impact
on
metabolism.
Dietary
modifications
lifestyle
changes
also
play
role
levels.
Keywords:
overload,
infection,
metabolism,
chelation,
disease,
Language: Английский
Hemochromatosis and HIV: Implications for Disease Progression
International Journal of Medical Sciences and Pharma Research,
Journal Year:
2024,
Volume and Issue:
10(2), P. 26 - 30
Published: July 15, 2024
Hemochromatosis,
a
genetic
disorder
characterized
by
excessive
iron
accumulation
in
the
body,
and
HIV,
virus
that
causes
immunodeficiency,
are
two
conditions
can
significantly
impact
each
other
when
co-present
an
individual.
This
review
explores
intersection
of
hemochromatosis
emphasizing
how
overload
influences
progression
HIV
infection.
Iron,
crucial
element
for
many
biological
processes,
also
plays
pivotal
role
viral
replication
immune
function,
making
its
dysregulation
particularly
relevant
HIV-infected
individuals.
Iron
exacerbate
disease
through
several
mechanisms.
Excess
enhance
providing
essential
co-factors
enzymes,
thus
increasing
load.
Additionally,
iron-induced
oxidative
stress
further
damage
cells
tissues,
compounding
already
present
Furthermore,
lead
to
immunosuppression,
patients
more
susceptible
opportunistic
infections
accelerating
decline
function
typically
seen
HIV.
The
clinical
management
with
both
requires
nuanced
approach
addresses
simultaneously.
Regular
monitoring
levels
liver
alongside
appropriate
use
antiretroviral
therapy
(ART)
potential
chelation
treatments,
optimal
care.
Keywords:
overload,
progression,
replication,
therapy,
Language: Английский