Medical and social portrait of a newly diagnosed tuberculosis patient with HIV infection in the Tomsk region

HIV Infection and Immunosuppressive Disorders, Journal Year: 2025, Volume and Issue: 16(4), P. 81 - 89

Published: Feb. 14, 2025

The aim. To identify the medical and social features of respiratory tuberculosis in newly diagnosed patients combination with HIV infection. Materials methods. For analysis, information was used on 1,234 verified or without infection during two follow-up periods (from January 2017 to March 2019 from November December 2021). Objectives study. conduct a dynamic analysis clinical epidemiological data infection; determine level multiple drug resistance MBT anti-tuberculosis drugs. Results discussion. A patient HIV-associated living an area high prevalence (Tomsk region) is mainly urban resident, young man aged 18–40 years, history 3 more not registered for quarter cases, severe immunodeficiency 60% cases. During observation period, proportion CD4 lymphocyte below 200 cells/ml increases (53.3% 60.9%, respectively, p=0.07), as pathogenetic result immunodeficiency, disseminated pulmonary proportionally (49.8% 63.8%, p=0.001); primary pathogen reaches frequency occurrence 43.1% TB/HIV, 23.8% (p<0.001). Conclusion. First identified HIV-infected region characterised by advanced course MDR improvement.

Language: Английский

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The trend of the HIV infection epidemic during the COVID-19 pandemic in the Republic of Тajikistan

HIV Infection and Immunosuppressive Disorders, Journal Year: 2025, Volume and Issue: 17(1), P. 62 - 68

Published: April 12, 2025

The aim. Analysis of the features development trend HIV epidemic process during COVID-19 pandemic in Republic Tajikistan. Materials and methods. data on prevalence incidence infection among general population were retrospectively analyzed based from Republican Center for Prevention Control AIDS Ministry Health Social Protection Results discussion. An analysis Tajikistan shows that country still has a high risk both most vulnerable cohorts people population. During period 2018–2019 (before pandemic), largest number new cases was detected. process, starting 2018, tended to gradually decrease mortality rates In 1,421 By end 2023, this figure 1,100 cases, is, it decreased by 1.3 times. 2020, 1,095 identified, which is 20.5% lower than 2019 (n=1,320), i.e. before pandemic. addition, coverage with testing 805,120 people, times less (n=1,062,509) 2019. pandemic, coronavirus HIV-infected 0.31% total cohort patients. Conclusion. despite slight infection, did not have significant impact country. This particular, associated volume restrictive measures introduced due worsening epidemiological situation COVID-19.

Language: Английский

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Risk groups of HIV infection among the population of the Omsk region

Sanitarnyj vrač (Sanitary Doctor), Journal Year: 2024, Volume and Issue: 10, P. 700 - 709

Published: Sept. 30, 2024

The peculiarities of the course epidemic process HIV infection, including formation certain risk groups by gender, age and social status, are relevant, as they allow development specific preventive measures. aim is to identify for infection among population Omsk region in 1996–2023. Data from main statistical reporting forms, Federal Register Persons Infected with Human Immunodeficiency Virus, results epidemiological investigations were used analysis. analysis made it possible establish trends region. general trend decreasing morbidity has been revealed, which coincides that Russian Federation, primarily due large volume measures carried out. Changes characteristics have established — contingents injecting drug users men who sex men, prevailing at an early stage epidemic, replaced persons became sexually infected individuals opposite sex. At same time, proportion women approached men. This entailed perinatal transmission infection. introduction mandatory screening markers pregnant implementation antiretroviral prophylaxis reduced number cases newborns a minimum. An increase share rural total structure newly diagnosed people may indicate both lower awareness this problem shortcomings provision medical care, its accessibility compared urban population. prevalence HIV-infected not engaged work indicates most socially unprotected involved process, rule, ready take care their own health others, often leading antisocial lifestyle. Thus, remains one priority problems requiring integrated approach solution. conducted research relation targeted strategies should be applied.

Language: Английский

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Current Trends in HIV Infection in the Republic of Crimea

Viruses, Journal Year: 2024, Volume and Issue: 16(11), P. 1716 - 1716

Published: Oct. 31, 2024

The aim of this study was to analyse the trends in HIV infection, including diagnostic ones, Republic Crimea period 2014-2023. source data for various statistical forms and reports. findings revealed a significant downward trend incidence upward prevalence. mortality rate stable. coverage testing antiretroviral therapy increased over time. number patients with suppressed viral load fluctuated different years observation reached 81% 2023. In second part study, we analysed demographic clinical laboratory characteristics newly diagnosed HIV. A predominance men noted. proportion injection drug users (IDUs) decreased, new infection cases through heterosexual contacts increased. An increase median age also Analysis CD4 cell counts differences between subgroups by gender, age, route infection. longest time disease detection typical IDUs. comprehensive assessment allows us evaluate effectiveness measures decisions taken on issue

Language: Английский

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Variability of non-structural proteins of HIV-1 sub-subtype A6 (Retroviridae: Orthoretrovirinae: Lentivirus: Human immunodeficiency virus-1, sub-subtype A6) variants circulating in different regions of the Russian Federation

Problems of Virology, Journal Year: 2024, Volume and Issue: 69(5), P. 470 - 480

Published: Nov. 9, 2024

HIV-1 non-structural proteins are promising targets for vaccine development and creating approaches to personalized medicine. sub-subtype A6 has become the dominating strain in Russia. However, geographic, economic demographic characteristics of country can contribute formation differences between variants circulating different regions. The aim study is a comparative analysis consensus sequences Amur Region, Arkhangelsk, Irkutsk Murmansk.

Language: Английский

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