Stress-Related LncRNAs and Their Roles in Diabetes and Diabetic Complications DOI Open Access
Lian Li, Yuqi Wu, Jine Yang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2194 - 2194

Published: Feb. 28, 2025

Diabetes mellitus (DM) is a chronic metabolic disorder and one of the most significant global health burdens worldwide. Key pathophysiological mechanisms underlying its onset associated complications include hyperglycemia-related stresses, such as oxidative stress endoplasmic reticulum (ER stress). Long non-coding RNAs (lncRNAs), defined RNA transcripts longer than 200 nucleotides lacking protein-coding capacity, play crucial roles in various biological processes have emerged regulators pathogenesis diabetes. This review provides comprehensive overview lncRNA biogenesis functional roles, emphasizing recent findings that link stress-related lncRNAs to diabetic pathology complications. Also, we discuss how influence diabetes by modulating pathways involved cell death, proliferation, inflammation, fibrosis, which contribute pancreatic β dysfunction, insulin resistance, nephropathy, retinopathy. By analyzing current research, aim enhance understanding involvement while identifying potential therapeutic targets guiding future research directions elucidate complex this pervasive condition.

Language: Английский

METTL3/YTHDC1 mediates up-regulation of lncRNA OGRU in an m6A-dependent manner involving in oxidative stress and inflammation of HG-induced Müller cells DOI
ShuHua Fu, Qianqian Zhou, Xin Peng

et al.

Immunology Letters, Journal Year: 2025, Volume and Issue: unknown, P. 106972 - 106972

Published: Jan. 1, 2025

Language: Английский

Citations

0
Stress-Related LncRNAs and Their Roles in Diabetes and Diabetic Complications DOI Open Access
Lian Li, Yuqi Wu, Jine Yang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2194 - 2194

Published: Feb. 28, 2025

Diabetes mellitus (DM) is a chronic metabolic disorder and one of the most significant global health burdens worldwide. Key pathophysiological mechanisms underlying its onset associated complications include hyperglycemia-related stresses, such as oxidative stress endoplasmic reticulum (ER stress). Long non-coding RNAs (lncRNAs), defined RNA transcripts longer than 200 nucleotides lacking protein-coding capacity, play crucial roles in various biological processes have emerged regulators pathogenesis diabetes. This review provides comprehensive overview lncRNA biogenesis functional roles, emphasizing recent findings that link stress-related lncRNAs to diabetic pathology complications. Also, we discuss how influence diabetes by modulating pathways involved cell death, proliferation, inflammation, fibrosis, which contribute pancreatic β dysfunction, insulin resistance, nephropathy, retinopathy. By analyzing current research, aim enhance understanding involvement while identifying potential therapeutic targets guiding future research directions elucidate complex this pervasive condition.

Language: Английский

Citations

0