Cardiovascular Diabetology,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: April 21, 2023
Abstract
Background
Women
have
a
high
risk
of
frailty
independently
age
and
menopause
state.
Diabetes
hypertension
increase
the
cognitive
impairment.
Metformin
has
been
employed
in
post-menopausal
women
some
reports
shown
encouraging
effects
terms
attenuated
frailty.
However,
impact
on
performance
recently
introduced
extended-release
formulation
metformin
never
explored.
Methods
We
studied
consecutive
frail
hypertensive
diabetic
older
presenting
at
ASL
(local
health
authority
Italian
Ministry
Health)
Avellino,
Italy,
from
June
2021
to
August
2022,
who
were
treated
or
not
with
metformin.
included
control
group
males
diabetes
regular
Results
A
total
145
patients
successfully
completed
study.
At
end
6-month
follow-up,
we
observed
significantly
different
compared
baseline
(p:
0.007).
Then,
follow-up
groups
significant
differences
between
vs.
untreated
0.041),
men
0.016),
0.048).
confirmed
crucial
role
applying
multivariable
logistic
analysis
adjust
for
potential
confounders.
Conclusions
evidenced,
first
time
best
our
knowledge,
favorable
impairment
hypertension.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(11), P. 3035 - 3035
Published: Nov. 12, 2023
Alzheimer’s
is
a
prevalent,
progressive
neurodegenerative
disease
marked
by
cognitive
decline
and
memory
loss.
The
disease’s
development
involves
various
pathomechanisms,
including
amyloid-beta
accumulation,
neurofibrillary
tangles,
oxidative
stress,
inflammation,
mitochondrial
dysfunction.
Recent
research
suggests
that
antidiabetic
drugs
may
enhance
neuronal
survival
function
in
diabetes.
Given
the
well-documented
correlation
between
diabetes
potential
shared
mechanisms,
this
review
aimed
to
comprehensively
assess
of
new-generation
anti-diabetic
drugs,
such
as
GLP-1
analogs,
SGLT-2
inhibitors,
DPP-4
promising
therapeutic
approaches
for
disease.
This
aims
applications
novel-generation
context
In
our
considered
opinion,
offer
avenue
groundbreaking
developments
have
revolutionize
landscape
treatment.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(16), P. 8811 - 8811
Published: Aug. 13, 2024
Heart
failure
(HF)
with
preserved
ejection
fraction
(HFpEF)
represents
a
major
comorbidity
in
the
elderly
and
is
associated
cognitive
impairment
(CoI)
type
2
diabetes
mellitus
(T2DM).
In
this
context,
there
an
increase
oxidative
stress
platelet
activation
biomarkers.
The
aim
of
study
was
to
evaluate
effects
6
months'
treatment
SGLT2i
on
functional,
mood-related,
aspects,
assessed
by
performing
comprehensive
geriatric
assessment
(CGA),
biomarkers,
cohort
HFpEF
patients
T2DM.
We
recruited
150
outpatients
(mean
age
75.8
±
7.4
years).
Cardiovascular Diabetology,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: April 21, 2023
Abstract
Background
Women
have
a
high
risk
of
frailty
independently
age
and
menopause
state.
Diabetes
hypertension
increase
the
cognitive
impairment.
Metformin
has
been
employed
in
post-menopausal
women
some
reports
shown
encouraging
effects
terms
attenuated
frailty.
However,
impact
on
performance
recently
introduced
extended-release
formulation
metformin
never
explored.
Methods
We
studied
consecutive
frail
hypertensive
diabetic
older
presenting
at
ASL
(local
health
authority
Italian
Ministry
Health)
Avellino,
Italy,
from
June
2021
to
August
2022,
who
were
treated
or
not
with
metformin.
included
control
group
males
diabetes
regular
Results
A
total
145
patients
successfully
completed
study.
At
end
6-month
follow-up,
we
observed
significantly
different
compared
baseline
(p:
0.007).
Then,
follow-up
groups
significant
differences
between
vs.
untreated
0.041),
men
0.016),
0.048).
confirmed
crucial
role
applying
multivariable
logistic
analysis
adjust
for
potential
confounders.
Conclusions
evidenced,
first
time
best
our
knowledge,
favorable
impairment
hypertension.
