Frontiers in Microbiology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 14, 2023
Previous
research
has
reported
that
the
gut
microbiota
performs
an
essential
role
in
sleep
through
microbiome-gut-brain
axis.
However,
causal
association
between
and
remains
undetermined.We
performed
a
two-sample,
bidirectional
Mendelian
randomization
(MR)
analysis
using
genome-wide
study
summary
data
of
self-reported
traits
from
MiBioGen
consortium
UK
Biobank
to
investigate
relationships
119
bacterial
genera
seven
sleep-associated
traits.
We
calculated
effect
estimates
by
inverse-variance
weighted
(as
main
method),
maximum
likelihood,
simple
model,
median,
MR-Egger
methods,
whereas
heterogeneity
pleiotropy
were
detected
measured
MR
residual
sum
outlier
method,
Cochran's
Q
statistics,
regression.In
forward
analysis,
concluded
genetic
forecasts
relative
abundance
42
had
effects
on
In
reverse
39
genera,
13
which
overlapped
with
analysis.In
conclusion,
our
indicates
may
be
involved
regulation
sleep,
conversely,
changes
also
alter
microbiota.
These
findings
suggest
underlying
reciprocal
sleep.
Frontiers in Cardiovascular Medicine,
Journal Year:
2023,
Volume and Issue:
10
Published: Nov. 24, 2023
Background
Ischemic
heart
disease
(IHD)
is
a
major
global
health
concern,
and
its
burden
among
young
adults
aged
25–49
years
remains
underexplored.
This
study
aims
to
provide
comprehensive
assessment
of
the
trends
IHD
over
past
30
(1990–2019)
this
age
group,
as
well
analyze
inequalities
related
socioeconomic
development.
Methods
Data
from
Global
Burden
Disease
Study
2019
(GBD
2019)
were
utilized
prevalence,
mortality,
disability-adjusted
life
(DALYs)
rate
globally.
Joinpoint
regression
analysis
was
applied
examine
period.
Health
inequality
performed
investigate
disparities
in
Socio-Demographic
Index
(SDI)
countries.
Results
According
GBD
data,
2019,
numbers
with
cases,
deaths,
DALYs
18,050,671
(95%
UI,
15,551,940–21,254,746),
597,137
(548,250–647,778),
28,692,968
(26,397,448–31,178,464),
respectively,
accounting
for
9.15%,
6.53%,
15.7%
total
cases.
Over
years,
mortality
[AAPC
=
−0.4%,
95%
CI
(−0.7%
−0.1%)]
−0.3%,
(−0.6%
decreased,
while
prevalence
0.4%,
(0.4%–0.4%)]
YLDs
(0.3%–0.4%)]
increased.
Furthermore,
countries
lower
levels
socio-demographic
index
disproportionately
bore
higher
adults.
The
slope
adult
shifted
−56.6
[95%
(−480.4–370.2)]
1990
−583.0
(−996.8
−169.2)]
concentration
moved
−8.2
(−8.5
−7.9)]
−13.2
(−13.9
−12.4)]
2019.
Conclusions
While
have
decreased
degree
SDI
has
continued
increase.
Decision-makers
various
should
allocate
resources
wisely
implement
effective
strategies
improve
globally
address
associated
it.
Diabetes/Metabolism Research and Reviews,
Journal Year:
2023,
Volume and Issue:
39(6)
Published: June 8, 2023
This
study
aimed
to
evaluate
the
association
of
sleep
quality
and
its
long-term
change
with
risk
type
2
diabetes
mellitus
(T2DM)
assess
relationship
between
duration
T2DM
according
categories
quality.5728
participants
free
at
wave
4
from
English
Longitudinal
Study
Ageing
were
included
received
a
follow-up
median
time
8
years.
We
created
score
quality,
which
was
based
on
three
Jenkins
Sleep
Problems
Scale
questions
(the
frequency
feeling
hard
fall
asleep,
waking
up
night,
tired
in
morning)
one
question
for
rating
overall
quality.
Participants
allocated
into
groups
their
baseline
scores
(groups
good
[4-8],
intermediate
[8-12],
poor
[12-16]).
assessed
by
self-reporting
hours
each
participant.411
(7.2%)
cases
documented
during
follow-up.
Compared
group,
subjects
showed
significantly
higher
(hazard
ratio
(HR)
1.45,
confidence
interval
(CI)
1.09,
1.92).
In
those
who
experienced
worsened
increased
(HR
1.77,
95%
CI
1.26,
2.49).
Type
not
changed
regardless
Short
(≤4h)
associated
an
elevated
both
short
prolonged
(≥9h)
group.Poor
is
correlated
increase
risk,
regulating
range
could
potentially
be
effective
approach
preventing
T2DM.
International Journal of Behavioral Nutrition and Physical Activity,
Journal Year:
2023,
Volume and Issue:
20(1)
Published: July 6, 2023
Sedentary
behavior
is
prevalent
among
people
with
diabetes
and
associated
unfavorable
cardiometabolic
health.
However,
there
limited
evidence
regarding
the
impact
of
replacing
sedentary
time
(ST)
physical
activity
on
mortality
in
prediabetes
diabetes.
We
prospectively
examined
association
between
accelerometer-measured
ST
after
adjusting
for
demographic
characteristics,
lifestyle
factors,
moderate-
to
vigorous-intensity
PA
(MVPA).
further
determined
effect
equal
different
types
activities
all-cause
mortality.We
included
1242
adults
1037
from
National
Health
Nutrition
Examination
Survey.
Restricted
cubic
splines
were
fitted
determine
dose-response
overall
mortality.
Isotemporal
substitution
modeling
was
used
explore
hazard
ratio
(HR)
effects
replacement.During
a
median
follow-up
14.1
years,
424
493
died.
Compared
lowest
tertile
ST,
multivariable-adjusted
HRs
highest
1.76
(95%
confidence
interval
[CI]
1.19,
2.60)
participants
(1.17,
2.65)
those
Additionally,
linear
observed
diabetes,
each
60
min/day
increment
1.19
(1.10,
1.30)
1.25
(1.12,
1.40),
respectively.
results
indicated
that
individuals
whose
replaced
by
30
min
light-intensity
(LPA)
MVPA
had
9%
40%
lower
mortality,
In
an
equivalent
LPA
also
risk
reduction
(HR
0.89;
95%
CI
0.84,
0.95
LPA;
HR
0.73;
0.49,
1.11
MVPA).Higher
manner
increased
premature
Statistically
potentially
beneficial
health
this
high-risk
population.
The
management
of
antidiabetic
therapy
in
people
with
type
2
diabetes
(T2D)
has
evolved
beyond
glycemic
control.
In
this
context,
Brazil
and
Portugal
defined
a
joint
panel
four
leading
societies
to
update
the
guideline
published
2020.The
panelists
searched
MEDLINE
(via
PubMed)
for
best
evidence
from
clinical
studies
on
treating
T2D
its
cardiorenal
complications.
without
disease
patients
atherosclerotic
cardiovascular
(ASCVD),
heart
failure
(HF),
or
diabetic
kidney
(DKD).
degree
recommendation
level
were
determined
using
predefined
criteria.All
need
have
their
(CV)
risk
status
stratified
HbA1c,
BMI,
eGFR
assessed
before
defining
therapy.
An
HbA1c
target
less
than
7%
is
adequate
most
adults,
more
flexible
(up
8%)
should
be
considered
frail
older
people.
Non-pharmacological
approaches
are
recommended
during
all
phases
treatment.
treatment
naïve
individuals
complications,
metformin
agent
choice
when
7.5%
below.
When
above
9%,
starting
dual
recommended,
triple
may
considered.
therapyt
Antidiabetic
drugs
proven
CV
benefit
(AD1)
reduce
events
if
patient
at
high
very
risk,
agents
efficacy
weight
reduction
obesity
present.
If
remains
target,
intensification
triple,
quadruple
therapy,
even
insulin-based
established
ASCVD,
AD1
(SGLT2
inhibitors
GLP-1
RA
benefit)
initially
outcomes,
second
necessary
improve
control
target.
HF,
SGLT2
HF
hospitalizations
mortality
HbA1c.
DKD,
combination
30
mL/min/1.73
m2.
can
continued
until
end-stage
disease.
Abstract
Background
To
explore
the
relationship
between
sleep
patterns
and
cardiovascular
disease
(CVD)
incidence
mortality
risk
in
a
population
with
type
2
diabetes
through
UK
Biobank
sample.
Methods
A
total
of
6860
patients
were
included
this
study.
Five
factors
(including
Chronotype,
duration,
insomnia,
daytime
sleepiness,
snoring)
collected
as
questionnaire.
The
calculation
generates
score
0–5,
then
three
defined
based
on
scores:
poor
pattern
(0–2),
Intermediate
(3–4),
healthy
(5).
HRs
95%
confidence
intervals
calculated
by
multivariate
COX
proportional
model
adjustment.
Restricted
cubic
splines
used
to
validate
linear
associations
scores
CVD
events.
Results
Our
results
found
reduced
events
individuals
compared
participants
patterns.
Mortality
(HR,
0.690;
CI
0.519–0.916),
ASCVD
(Atherosclerosis
CVD)
0.784;
0.671–0.915),
CAD
(Coronary
Artery
Disease)
0.737;
0.618–0.879),
PAD
(Peripheral
Arterial
0.612;
0.418–0.896),
Heart
Failure
0.653;
0.488–0.875).
spline
responded
negative
correlation
Mortality,
ASCVD,
CAD,
PAD,
Failure.
Conclusions
Healthy
are
significantly
associated
population.
INQUIRY The Journal of Health Care Organization Provision and Financing,
Journal Year:
2024,
Volume and Issue:
61
Published: Jan. 1, 2024
To
identify
key
factors
affecting
all-cause
mortality
in
the
elderly
aged
80
years
and
above.
Data
from
Chinese
Longitudinal
Healthy
Longevity
Survey
(2011-2018)
were
utilized
(
Journal of Clinical Medicine,
Journal Year:
2023,
Volume and Issue:
12(8), P. 2899 - 2899
Published: April 16, 2023
Background:
This
study
aimed
to
investigate
whether
sleep
duration
and/or
quality
are
associated
with
incident
diabetes
mellitus
(DM).
Methods:
A
total
of
8816
10,030
healthy
participants
were
enrolled
in
a
prospective
cohort
study.
Sleep
and
questionnaires
completed.
was
assessed
using
the
Epworth
Sleepiness
Scale
(ESS),
which
measures
excessive
daytime
sleepiness
individuals.
Results:
During
14-year
follow-up
period,
18%
(1630/8816)
diagnosed
DM.
U-shaped
relationship
observed
between
DM,
highest
risk
when
≥10
h/day
(hazard
ratios
(HR)
1.65
[1.25–2.17]).
group
exhibited
decreased
insulin
glycogenic
index,
marker
secretory
function,
during
period.
Among
who
slept
less
than
10
h/day,
DM
increased
ESS
score
>10.
Conclusions:
We
found
that
association
U-shaped;
both
short
(≤5
h)
long
(≥10
durations
an
for
occurrence
When
h
or
longer
per
day,
there
tendency
develop
due
function.
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 19, 2024
Aims
This
research
investigated
menopausal
women
older
than
50
years
to
find
whether
there
were
any
independent
relationships
between
the
duration
of
sleep
they
got
and
their
prevalence
depression.
Methods
National
Health
Nutrition
Examination
Survey
(NHANES)
datasets
from
2011-2020
utilized
in
a
cross-sectional
study.
Using
multivariate
linear
regression
models,
relationship
depression
was
investigated.
Fitted
smoothing
curves
thresholds
impact
evaluation
used
investigate
nonlinear
relationship.
Then,
subgroup
analyses
performed
according
smoking,
drinking
alcohol,
diabetes,
hypertension,
heart
disease,
moderate
activities.
Results
population-based
study
included
total
3,897
(mean
age
65.47
±
9.06
years)
aged≥50
years;
3,159
had
score
<10,
738
score≥10.
After
controlling
for
all
covariates,
17%
higher
among
participants
with
short
[
OR
=1.17,
95%CI=(0.65,
1.70),
P
<0.0001]
86%
=1.86,
95%CI=(1.05,
2.66),
compared
normal
duration.
In
stratified
by
smoking
scores
non-smokers
β
=-0.18,
95%CI=
(-0.33,
-0.02),
=0.0241]
diabetics
independently
negatively
correlated
=-0.32,
(-0.63,
-0.01),
=0.0416].
two-segment
model,
we
discovered
U-shaped
an
inflection
point
7.5
hours.
Less
hours
associated
increased
risk
developing
=-0.81,
(-1.05,
-0.57),
<0.001].
However,
sleeping
more
per
night
considerably
=0.80,
(0.51,
1.08),
Conclusions
Depression
is
women.
Insufficient
or
excessive
may
increase
