Food & Function,
Journal Year:
2024,
Volume and Issue:
15(7), P. 3864 - 3875
Published: Jan. 1, 2024
The
triglyceride
glucose
(TyG)
index
is
a
reliable
marker
of
insulin
resistance;
however,
its
combined
impact
with
modifiable
lifestyle
risk
factors
and
psychological
traits
on
cardiovascular
diseases
(CVDs)
remains
unclear.
Diabetes Obesity and Metabolism,
Journal Year:
2024,
Volume and Issue:
26(7), P. 2869 - 2880
Published: April 29, 2024
Abstract
Aim
To
investigate
the
associations
of
individual
and
combined
healthy
lifestyle
factors
(HLS)
with
risk
stroke
in
individuals
diabetes
China.
Methods
This
prospective
analysis
included
41
314
[15
191
from
Comprehensive
Research
on
Prevention
Control
Diabetes
(CRPCD)
project
26
123
China
Kadoorie
Biobank
(CKB)
study].
Associations
factors,
including
cigarette
smoking,
alcohol
consumption,
physical
activity,
diet,
body
shape
sleep
duration,
stroke,
intracerebral
haemorrhage
(ICH)
ischaemic
(IS)
were
assessed
using
Cox
proportional
hazard
models.
Results
During
median
follow‐up
periods
8.02
9.05
years,
2499
4578
cases
2147
4024
IS,
160
728
ICH
documented
CRPCD
CKB
cohorts,
respectively.
In
cohort,
patients
≥5
HLS
had
a
14%
lower
(hazard
ratio
(HR):
0.86,
95%
confidence
interval
(CI):
0.75‐0.98)
than
those
≤2
HLS.
adjusted
HR
(95%
CI)
for
0.74
(0.66‐0.83)
0.57
(0.42‐0.78)
compared
The
pooled
comparing
versus
was
0.79
(0.69‐0.92)
0.80
(0.68‐0.93)
0.60
(0.46‐0.78)
ICH.
Conclusions
Maintaining
associated
IS
among
diabetes.
Rejuvenation Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 30, 2025
The
study
aimed
to
explore
the
association
between
different
sleep
traits
and
all-cause
mortality
as
well
validate
causality
in
through
mendelian
randomization
(MR).
We
analyzed
451,420
European
ancestry
participants
from
UK
Biobank.
Multivariable-adjusted
Cox
proportional
hazards
model
was
conducted
evaluate
mortality.
In
MR
analysis,
inverse
variance
weighting
(IVW)
method
applied
primary
analysis
investigate
causal
During
a
median
follow-up
period
of
12.68
years,
34,397
individuals
died.
Observational
analyses
showed
multivariate-adjusted
hazard
ratio
(HR)
95%
confidence
intervals
(CIs)
for
short
sleep,
long
early
chronotype,
daytime
sleepiness,
napping,
insomnia
with
mortality,
1.246
(1.195,
1.298),
1.735
(1.643,
1.831),
0.931
(0.909,
0.953),
1.276
(1.212,
1.344),
1.299
(1.254,
1.346),
1.117
(1.091,
1.142)
(All
p
<
0.0001).
Based
on
Biobank,
indicated
napping
an
increased
risk
(odd
[OR]:
1.219,
CI:
1.071-1.387,
=
0.003),
which
may
be
largely
attributable
cancer
disease
(OR:
1.188,
1.009-1.399,
0.039).
found
no
duration,
insomnia,
risk.
associations
were
directionally
replicated
FinnGen.
Our
findings
suggest
potential
middle-aged
older
persons.
finding
could
have
important
implications
evaluating
habits
decrease
American Journal of Hematology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 30, 2025
ABSTRACT
Previous
research
indicates
an
association
between
sleep
traits
and
venous
thromboembolism
(VTE)
risk,
though
causal
relationships
remain
uncertain.
This
study
evaluated
combined
independent
associations
VTE
risk
using
UK
Biobank
data
explored
the
through
two‐sample
Mendelian
randomization
(MR)
analyses.
Hazard
ratios
(HRs)
95%
confidence
intervals
(95%
CIs)
for
healthy
score,
as
well
individual
(including
duration,
insomnia,
daytime
sleepiness,
snoring,
chronotype),
were
calculated
Cox
proportional
hazards
regression
models.
Additionally,
MR
analyses
used
inverse‐variance
weighted
method
to
determine
odds
(ORs)
CIs
associations.
In
cohort
analysis,
314
077
VTE–free
participants
followed
a
median
of
12.3
years,
during
which
7176
cases
occurred.
comparison
those
with
score
0–1,
5
associated
30%
lower
(HR:
0.70;
CI:
0.61–0.80).
A
U‐shaped
was
noted
duration
risk.
Both
short
(≤
6
h)
long
(≥
9
durations
increased
Excessive
evening
chronotype
also
elevated
supported
relationship
(OR:
1.24;
1.04–1.47)
while
other
showed
no
association.
These
findings
underscore
importance
optimal
in
reducing
