Dopamine in the Regulation of Glucose Homeostasis, Pathogenesis of Type 2 Diabetes, and Chronic Conditions of Impaired Dopamine Activity/Metabolism: Implication for Pathophysiological and Therapeutic Purposes DOI Creative Commons
Giuseppe Lisco, Anna De Tullio,

Michele Iovino

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(11), P. 2993 - 2993

Published: Nov. 7, 2023

Dopamine regulates several functions, such as voluntary movements, spatial memory, motivation, sleep, arousal, feeding, immune function, maternal behaviors, and lactation. Less clear is the role of dopamine in pathophysiology type 2 diabetes mellitus (T2D) chronic complications conditions frequently associated with it. This review summarizes recent evidence on regulating insular metabolism activity, traditional T2D, pathophysiological interconnection between T2D neurological psychiatric disorders characterized by impaired activity/metabolism, therapeutic implications. Reinforcing signaling especially patients dopamine-related disorders, Parkinson’s Huntington’s diseases, addictions, attention-deficit/hyperactivity disorder. On other hand, although specific trials are probably needed, certain medications approved for (e.g., metformin, pioglitazone, incretin-based therapy, gliflozins) may have a due to anti-inflammatory anti-oxidative effects, improvement insulin signaling, neuroinflammation, mitochondrial dysfunction, autophagy, apoptosis, restoration striatal synthesis, modulation reward hedonic eating. Last, targeting could potential diagnostic purposes diabetes-related complications, diabetic retinopathy.

Language: Английский

Smartphone Applications to Prevent Type 2 Diabetes: A Systematic Review and Meta-Analysis DOI
Esrat Jahan,

Rawan Almansour,

Kiran Ijaz

et al.

American Journal of Preventive Medicine, Journal Year: 2024, Volume and Issue: 66(6), P. 1060 - 1070

Published: Jan. 24, 2024

Language: Английский

Citations

5
Perioperative Considerations for Patients on Semaglutide DOI
Sher‐Lu Pai, Michael A. Smith, William B. Beam

et al.

Current anesthesiology reports, Journal Year: 2024, Volume and Issue: 14(2), P. 152 - 160

Published: Jan. 31, 2024

Language: Английский

Citations

5
Replacing of sedentary behavior with physical activity and the risk of mortality in people with prediabetes and diabetes: a prospective cohort study DOI Creative Commons
Ping Zhu,

Guojuan Lao,

Huipeng Li

et al.

International Journal of Behavioral Nutrition and Physical Activity, Journal Year: 2023, Volume and Issue: 20(1)

Published: July 6, 2023

Sedentary behavior is prevalent among people with diabetes and associated unfavorable cardiometabolic health. However, there limited evidence regarding the impact of replacing sedentary time (ST) physical activity on mortality in prediabetes diabetes. We prospectively examined association between accelerometer-measured ST after adjusting for demographic characteristics, lifestyle factors, moderate- to vigorous-intensity PA (MVPA). further determined effect equal different types activities all-cause mortality.We included 1242 adults 1037 from National Health Nutrition Examination Survey. Restricted cubic splines were fitted determine dose-response overall mortality. Isotemporal substitution modeling was used explore hazard ratio (HR) effects replacement.During a median follow-up 14.1 years, 424 493 died. Compared lowest tertile ST, multivariable-adjusted HRs highest 1.76 (95% confidence interval [CI] 1.19, 2.60) participants (1.17, 2.65) those Additionally, linear observed diabetes, each 60 min/day increment 1.19 (1.10, 1.30) 1.25 (1.12, 1.40), respectively. results indicated that individuals whose replaced by 30 min light-intensity (LPA) MVPA had 9% 40% lower mortality, In an equivalent LPA also risk reduction (HR 0.89; 95% CI 0.84, 0.95 LPA; HR 0.73; 0.49, 1.11 MVPA).Higher manner increased premature Statistically potentially beneficial health this high-risk population.

Language: Английский

Citations

13
The Mediterranean Diet: Effects on Insulin Resistance and Secretion in Individuals with Overweight or Obesity DOI Open Access
Claudia Vetrani, Ludovica Verde, Annamaria Colao

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(21), P. 4524 - 4524

Published: Oct. 25, 2023

High adherence to the Mediterranean Diet (MD) is associated with a lower risk of type 2 diabetes. However, it less clear whether different MD food items might influence specific biological functions related glucose tolerance, i.e., insulin resistance (IR) and/or secretion (IS). Thus, this cross-sectional study aimed investigate relationship between and IR, sensitivity, IS in individuals overweight/obesity. Participants (62 individuals; 7M/55F; mean age 49 ± 15 years; BMI 35.8 6.7 kg/m²) underwent 75 g oral tolerance test (OGTT) assess plasma concentrations. These parameters were used for calculation validated IR indices (Homeostatic Model Assessment Insulin Resistance (HOMA-IR), Homeostatic β-cell function (HOMA-β)), as well sensitivity (insulin index (ISI), (OGIS)). was gauged using PREDIMED questionnaire. Bivariate correlations highlight association OGTT-derived (PREDIMED score) or foodstuffs MD. Despite there being no significant differences BMI, impaired fasting (IFG), (IGT), high group presented HOMA-IR (p = 0.022) higher ISI 0.033) compared other groups. inversely correlated (r −0.400; p 0.004) directly 0.296, 0.039). Fish consumption, key component MD, exhibited associations: 0.394, 0.005) −0.327, 0.019) −0.489, < 0.001). In conclusion, adherence, particular consumption fish, decreased

Language: Английский

Citations

12
Dopamine in the Regulation of Glucose Homeostasis, Pathogenesis of Type 2 Diabetes, and Chronic Conditions of Impaired Dopamine Activity/Metabolism: Implication for Pathophysiological and Therapeutic Purposes DOI Creative Commons
Giuseppe Lisco, Anna De Tullio,

Michele Iovino

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(11), P. 2993 - 2993

Published: Nov. 7, 2023

Dopamine regulates several functions, such as voluntary movements, spatial memory, motivation, sleep, arousal, feeding, immune function, maternal behaviors, and lactation. Less clear is the role of dopamine in pathophysiology type 2 diabetes mellitus (T2D) chronic complications conditions frequently associated with it. This review summarizes recent evidence on regulating insular metabolism activity, traditional T2D, pathophysiological interconnection between T2D neurological psychiatric disorders characterized by impaired activity/metabolism, therapeutic implications. Reinforcing signaling especially patients dopamine-related disorders, Parkinson’s Huntington’s diseases, addictions, attention-deficit/hyperactivity disorder. On other hand, although specific trials are probably needed, certain medications approved for (e.g., metformin, pioglitazone, incretin-based therapy, gliflozins) may have a due to anti-inflammatory anti-oxidative effects, improvement insulin signaling, neuroinflammation, mitochondrial dysfunction, autophagy, apoptosis, restoration striatal synthesis, modulation reward hedonic eating. Last, targeting could potential diagnostic purposes diabetes-related complications, diabetic retinopathy.

Language: Английский

Citations

12