Impact of COVID-19 infection on mortality, diabetic complications and haematological parameters in patients with diabetes mellitus: a systematic review and meta-analysis DOI Creative Commons
Jialing Zhang,

Yanfang Ma,

Wing Lam To

et al.

BMJ Open, Journal Year: 2025, Volume and Issue: 15(3), P. e090986 - e090986

Published: March 1, 2025

Objectives SARS-CoV-2 poses significant challenges to people living with diabetes (PLWD). This systematic review aimed explore the impact of COVID-19 on mortality, complications associated and haematological parameters among PLWD. Design Systematic meta-analysis using Grading Recommendations Assessment, Development Evaluation (GRADE). Data sources EMBASE, MEDLINE, Cochrane Central Register Controlled Trials LILACS were searched between 1 December 2019 14 January 2025. Eligibility criteria for selecting studies Eligible included case-control cohort involving PLWD categorised into two groups: those confirmed infection without. extraction synthesis Meta-analyses estimated odds ratios (ORs) mean differences (MDs) outcomes including intensive care unit (ICU) admission, diabetic ketoacidosis (DKA), acute kidney injury, hospitalisation length parameters. We pooled results random-effects models assessed study quality Newcastle-Ottawa Scale. A funnel plot was used detect potential publication bias. The overall certainty evidence GRADE. Results 25 7266 unique eligible, 154674 (561 558 593 116 without COVID-19). in significantly increased mortality (OR 2.52, 95% CI 1.45 4.36, I 2 =99%), injury (3.69, 2.75 4.94, =0%), random plasma glucose subjects type (MD 20.38 mg/dL, 7.39 33.36, haemoglobin A1C (0.21%, 0.05 0.38, =13%), creatinine (0.12 0.04 0.19, C reactive protein (38.30 mg/L, 4.79 71.82, =82%) D-dimer (1.52 µg/mL, 0.73 2.31, =0%). No observed incidence ICU admission DKA, length, haemoglobin, leucocyte, lymphocyte, neutrophil lymphocyte ratio, platelet, blood urea nitrogen, glomerular filtration rate, procalcitonin, albumin, ferritin bilirubin infection. Conclusions is elevated risks poor glycaemic control PLWD, alongside levels inflammatory coagulation biomarkers. These findings underscore urgent need tailored clinical management strategies COVID-19. PROSPERO registration number CRD42023418039.

Language: Английский

Contribution of infection to mortality in people with type 2 diabetes: a population-based cohort study using electronic records DOI Creative Commons

Iain M. Carey,

Julia Critchley,

Umar Chaudhry

et al.

The Lancet Regional Health - Europe, Journal Year: 2024, Volume and Issue: 48, P. 101147 - 101147

Published: Nov. 27, 2024

Language: Английский

Citations

4
Animal Models for Long COVID: Current Advances, Limitations, and Future Directions DOI
Yu Zhang, Huan Chen, Yumeng Li

et al.

Journal of Medical Virology, Journal Year: 2025, Volume and Issue: 97(2)

Published: Feb. 1, 2025

ABSTRACT Long COVID (LC) represents a chronic, systemic, and often disabling condition that poses significant ongoing threat to public health. Foundational scientific studies are needed unravel the underlying mechanisms, with ultimate goal of developing effective preventative therapeutic strategies. Therefore, there is an urgent demand for animal models can accurately replicate clinical features LC. This review integrates epidemiological data summarize pathological changes in extrapulmonary systems involved Additionally, it critically examines capacity existing models, including nonhuman primates, genetically modified mice, Syrian hamsters, exhibit enduring postinfection symptoms align human manifestations, identifies key areas requiring further development. The objective offer insights will aid development next‐generation thereby accelerating our understanding how acute respiratory viral infections transition into chronic conditions, ensuring preparedness future pandemics.

Language: Английский

Citations

0
Impact of COVID-19 infection on mortality, diabetic complications and haematological parameters in patients with diabetes mellitus: a systematic review and meta-analysis DOI Creative Commons
Jialing Zhang,

Yanfang Ma,

Wing Lam To

et al.

BMJ Open, Journal Year: 2025, Volume and Issue: 15(3), P. e090986 - e090986

Published: March 1, 2025

Objectives SARS-CoV-2 poses significant challenges to people living with diabetes (PLWD). This systematic review aimed explore the impact of COVID-19 on mortality, complications associated and haematological parameters among PLWD. Design Systematic meta-analysis using Grading Recommendations Assessment, Development Evaluation (GRADE). Data sources EMBASE, MEDLINE, Cochrane Central Register Controlled Trials LILACS were searched between 1 December 2019 14 January 2025. Eligibility criteria for selecting studies Eligible included case-control cohort involving PLWD categorised into two groups: those confirmed infection without. extraction synthesis Meta-analyses estimated odds ratios (ORs) mean differences (MDs) outcomes including intensive care unit (ICU) admission, diabetic ketoacidosis (DKA), acute kidney injury, hospitalisation length parameters. We pooled results random-effects models assessed study quality Newcastle-Ottawa Scale. A funnel plot was used detect potential publication bias. The overall certainty evidence GRADE. Results 25 7266 unique eligible, 154674 (561 558 593 116 without COVID-19). in significantly increased mortality (OR 2.52, 95% CI 1.45 4.36, I 2 =99%), injury (3.69, 2.75 4.94, =0%), random plasma glucose subjects type (MD 20.38 mg/dL, 7.39 33.36, haemoglobin A1C (0.21%, 0.05 0.38, =13%), creatinine (0.12 0.04 0.19, C reactive protein (38.30 mg/L, 4.79 71.82, =82%) D-dimer (1.52 µg/mL, 0.73 2.31, =0%). No observed incidence ICU admission DKA, length, haemoglobin, leucocyte, lymphocyte, neutrophil lymphocyte ratio, platelet, blood urea nitrogen, glomerular filtration rate, procalcitonin, albumin, ferritin bilirubin infection. Conclusions is elevated risks poor glycaemic control PLWD, alongside levels inflammatory coagulation biomarkers. These findings underscore urgent need tailored clinical management strategies COVID-19. PROSPERO registration number CRD42023418039.

Language: Английский

Citations

0