Applied and Computational Engineering,
Journal Year:
2024,
Volume and Issue:
57(1), P. 206 - 211
Published: April 29, 2024
This
paper
delves
into
the
transformative
impact
of
machine
learning
(ML)
on
portfolio
optimization,
showcasing
how
ML
algorithms
can
significantly
enhance
traditional
financial
models
such
as
Capital
Asset
Pricing
Model
(CAPM)
and
Arbitrage
Theory
(APT).
Through
a
comprehensive
examination
regression
analysis,
classification
algorithms,
reinforcement
learning,
we
illustrate
methodologies
by
which
refines
prediction
asset
returns,
assesses
investment
risks,
dynamically
adjusts
allocations.
We
discuss
integration
with
CAPM
APT
to
improve
estimation
systematic
risk
identify
multi-factor
influences
offering
more
nuanced
approach
optimizing
portfolios.
Additionally,
highlights
role
big
data
in
augmenting
predictive
accuracy
application
optimization
like
Gradient
Descent
Genetic
Algorithms
achieving
optimal
By
addressing
challenges
multicollinearity
overfitting,
demonstrate
potential
revolutionize
strategies,
enabling
sophisticated
management
return
maximization.
study
not
only
underscores
synergy
between
theories
but
also
paves
way
for
future
innovations
analytics.
Lipids in Health and Disease,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 7, 2025
Fatty
acid
metabolism,
exercise,
and
insulin
action
play
critical
roles
in
maintaining
vascular
health,
especially
relevant
metabolic
disorders
such
as
obesity,
type
2
diabetes,
cardiovascular
disease.
Insulin,
a
vasoactive
hormone,
induces
arterial
vasodilation
throughout
the
tree,
increasing
compliance
enhancing
tissue
perfusion.
These
effects,
however,
are
impaired
individuals
with
obesity
evidence
suggests
that
resistance
contributes
to
pathogenesis
of
diabetes
its
complications.
Elevated
plasma
levels
free
fatty
acids
people
engender
inflammation,
endothelial
dysfunction,
resistance.
Importantly,
these
effects
both
functionally
structurally
dependent,
saturated
primary
culprits,
while
polyunsaturated
may
support
sensitivity
function.
Exercise
enhances
oxidation,
reduces
circulating
acids,
improves
sensitivity,
thereby
mitigating
lipotoxicity
promoting
Additionally,
exercise
beneficial
adaptations.
This
review
examines
complex
interplay
among
training-induced
adaptations,
insulin-mediated
changes,
highlighting
their
collective
impact
on
health
underlying
mechanisms
healthy
insulin-resistant
states.
It
also
explores
therapeutic
potential
targeted
prescriptions
acid-focused
dietary
strategies
for
emphasizing
tailored
interventions
maximize
benefits.
Future
research
should
investigate
pathways
linking
metabolism
resistance,
focus
how
modifications
can
be
personalized
enhance
optimize
reduce
risks
associated
Journal of the American Nutrition Association,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 8
Published: Feb. 5, 2025
Objective
This
study
aimed
to
investigate
the
association
between
zinc
deficiency
(ZD)
and
risks
of
all-cause
mortality,
major
adverse
cardiovascular
events
(MACEs),
kidney
(MAKEs),
hospitalization
in
diabetic
patients.
Frontiers in Endocrinology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 6, 2025
The
combination
of
cardiovascular
disease
and
diabetes
is
a
highly
prevalent
condition
in
the
United
Arab
Emirates.
Development
dissemination
evidence-based
regional
recommendations
for
optimal
screening,
treatment
referrals
people
with
high
risk
an
important
priority.
An
expert
panel
diabetologists,
endocrinologists
cardiologists
from
Emirates
Cardiac
Society
Diabetes
Endocrine
as
well
different
entities
UAE,
discussed
reviewed
evidence
also
consensus
report
American
Association
to
formulate
contextualized
that
could
be
applied
management
UAE.
heart
failure
other
risks
finding
among
causal
inter-relationships
between
are
multifactorial
regular
assessments
symptoms
steps
mitigation
factors
universal
definition
classification
provides
useful
framework
recommending
treatment,
referral
strategies
diabetic
individuals
at
various
stages
continuum.
Routine
measurement
(at
least
yearly)
natriuretic
peptides
high-sensitivity
troponins
can
help
identify
patients
requiring
cardiac
imaging
referrals.
However,
routine
measurements
and/or
all
must
balance
clinical
judgment
cost
implications.
While
SGLT2i
part
standard
care,
insulin,
GLP1
receptor
agonists
metformin
additional
glycemic
control.
hopes
presented
herein
offer
guidance
concomitance
Expert Opinion on Pharmacotherapy,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 11
Published: Jan. 11, 2025
Introduction
Atherogenic
dyslipidemia
with
increased
triglycerides,
low
high-density
lipoprotein
cholesterol
levels
and
small
dense
low-density
(LDL)
particles
is
a
major
risk
factor
contributing
to
the
cardiovascular
(CV)
in
patients
type
2
diabetes
(T2D).
This
regarded
as
residual
after
achieving
target
of
LDL
cholesterol.
Journal of Medical and Biosciences Research.,
Journal Year:
2025,
Volume and Issue:
2(1), P. 292 - 303
Published: Jan. 19, 2025
O
presente
estudo
revisou
as
estratégias
de
tratamento
e
prevenção
das
complicações
cardíacas
associadas
ao
diabetes
tipo
2,
utilizando
uma
abordagem
revisão
integrativa.
objetivo
foi
avaliar
intervenções
terapêuticas
preventivas
disponíveis
para
minimizar
os
riscos
cardiovasculares
em
indivíduos
com
2.
A
metodologia
consistiu
integrativa
realizada
nas
bases
dados
Scientific
Electronic
Library
Online
(SCIELO),
Cochrane
Medline,
descritores
ciências
da
saúde
relacionados
tema,
como
"Diabetes
Mellitus,
Type
2”,
“Cardiovascular
Diseases”,
“Preventive
Health
Services”.
Os
resultados
indicaram
que
a
combinação
controle
glicêmico
rigoroso,
farmacológicas
(como
inibidores
SGLT2
agonistas
do
GLP-1),
mudanças
no
estilo
vida,
dieta
exercícios
físicos,
são
eficazes
na
redução
cardíacas.
No
entanto,
desafios
incluem
adesão
necessidade
personalizadas
diferentes
perfis
pacientes.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 340 - 340
Published: Feb. 3, 2025
Background/Objectives:
Dementia
associated
with
diabetes
mellitus
(DM)
has
been
well
documented
in
the
literature,
but
studies
utilizing
early
screening
tools
to
target
populations
mild
cognitive
dysfunction
remain
limited.
This
study
aimed
investigate
decline
by
studying
relationships
between
“Ascertain
8”
(AD8)
questionnaire
scores
and
glycemic
control,
lipid
profiles,
estimated
glomerular
filtration
rate
(eGFR),
complications
of
diabetes.
Methods:
case–control,
cross-sectional,
observational
was
conducted
at
a
medical
center
an
affiliated
regional
hospital
southern
Taiwan
from
30
June
2021
2023.
Patients
diagnosed
type
2
aged
≥40
years
were
recruited.
Their
past
history,
biochemical
data,
AD8
score
collected
same
time.
Results:
The
patients
glycated
hemoglobin
(HbA1c)
levels
≥7%
had
higher
risk
impairment
than
those
HbA1c
<7%
(p
<
0.001).
participants
whose
eGFR
<60
mL/min/1.73
m2
mean
compared
≥60
=
0.008).
history
peripheral
artery
disease
diabetic
neuropathy
also
0.001
p
0.017,
respectively).
Conclusions:
By
employing
as
sensitive
tool,
our
suggests
that
is
significantly
poorer
lower
rate,
disease,
neuropathy.
Early
detection
these
factors
may
facilitate
timely
interventions
tailored
treatment
strategies
treat
or
prevent
dysfunction.
Ophthalmology Science,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100734 - 100734
Published: Feb. 1, 2025
To
evaluate
whether
glucagon-like
peptide-1
receptor
agonists
(GLP-1RAs)
are
associated
with
reduced
retinal
vein
occlusion
(RVO)
risk
compared
dipeptidyl
peptidase-4
(DPP-4)
inhibitors
in
patients
type
2
diabetes
mellitus
(T2DM).
A
multinational,
retrospective
cohort
study.
Adults
T2DM
newly
prescribed
GLP-1RAs
or
DPP-4
between
2006
and
2023
were
included
our
analysis.
This
study
leveraged
data
from
populations
across
21
countries.
Propensity
score
matching
at
a
1:1
ratio
balanced
age,
sex,
race,
glycated
hemoglobin
(HbA1c),
body
mass
index
(BMI),
estimated
glomerular
filtration
rate,
medications,
comorbidities
GLP-1RA
DPP4
inhibitor
users.
We
observed
the
occurrence
of
incident
RVO
branch
(BRVO)
overall
population
subpopulations
stratified
by
type,
baseline
HbA1c,
BMI,
duration.
Among
79
486
matched
participants,
use
is
lower
(hazard
[HR],
0.73;
95%
confidence
interval
[CI],
0.54-0.98)
BRVO
(HR,
0.62;
CI,
0.41-0.95)
over
5
years
use.
association
consistent
among
aged
≥50
years,
Blacks,
those
human-analog
GLP-1RAs,
HbA1c
≥8%,
BMI
≥30
kg/m2,
duration
≥3
years.
Glucagon-like
agonist
was
linked
to
risks
when
use,
particularly
high-risk
populations,
suggesting
potential
benefits
managing
ocular
complications
T2DM.
Proprietary
commercial
disclosure
may
be
found
Footnotes
Disclosures
end
this
article.
