Skin Microbiome and Acne: Microbial Imbalances and Impact – Interview with Three Key Opinion Leaders DOI Creative Commons

Brigitte Scott

EMJ Dermatology, Journal Year: 2024, Volume and Issue: unknown, P. 83 - 94

Published: Nov. 7, 2024

Acne vulgaris, commonly known as acne, is a multifactorial, chronic inflammatory skin condition involving the pilosebaceous unit, and one of most common diseases globally. significantly impacts quality life wellbeing patients, can be associated with anxiety, depression, low self-esteem. This also substantial healthcare costs economic burden for society. The treatment acne complex challenging. For this article, EMJ conducted an interview in September 2024 key opinion leaders Marco Rocha from Federal University São Paulo, Brazilian Society Dermatology, Brazil; Thomas Dirschka CentroDerm Clinic, Wuppertal, Witten-Herdecke, Germany; Alison Layton Skin Research Centre, Hull York Medical School, York, Harrogate District NHS Foundation Trust, UK. leaders, who have wealth experience expertise clinical management were asked about current landscape potential role microbiome development disease. experts provided valuable insights into some many unmet needs management, particularly overuse antibiotics lack effective alternative therapies condition. discussed contribution microbial imbalances prebiotics probiotics restoring health. concept integrating microbiome-modulating strategies conventional treatment, whether there connection between psychological conditions such considered. A further topic covered was educating patients parents acne. Finally, outlined what future might look like.

Language: Английский

The Role of the Skin Microbiome in Acne: Challenges and Future Therapeutic Opportunities DOI Open Access

Alicja Niedźwiedzka,

Maria Pia Micallef,

Manuele Biazzo

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11422 - 11422

Published: Oct. 24, 2024

Acne vulgaris is a widespread dermatological condition that significantly affects the quality of life adolescents and adults. Traditionally, acne pathogenesis has been linked to factors such as excess sebum production, follicular hyperkeratinization, presence

Language: Английский

Citations

5
Efficacy of Probiotic Supplements and Topical Applications in the Treatment of Acne: A Scoping Review of Current Results DOI Creative Commons
Ida Ayu Manik Partha Sutema, Irma Rahayu Latarissa, I Gusti Ayu Rai Widowati

et al.

Journal of Experimental Pharmacology, Journal Year: 2025, Volume and Issue: Volume 17, P. 1 - 14

Published: Jan. 1, 2025

Abstract: Acne vulgaris is a prevalent dermatological condition characterized by comedones, papules, and pustules, with significant physical psychological implications. Conventional treatments for this condition, including antibiotics retinoids, face challenges, such as side effects antibiotic resistance, necessitating alternative treatments. Recent studies show the potential of probiotics to modulate skin microbiome alleviate acne symptoms. Therefore, study aimed consolidate evidence from randomized controlled trials (RCTs) clinical investigations, evaluating efficacy in management. A comprehensive literature search was conducted across PubMed, Scopus, Cochrane databases using several keywords, "probiotic", "microbiome", "acne vulgaris". Inclusion criteria are RCTs 2009 2024 examining treatment. Studies were selected, screened, analyzed based on population, intervention, design, results. Descriptive statistics used summarize characteristics. Fifteen 811 participants met inclusion criteria. The tested various oral topical probiotics, Lactobacillus, Bifidobacterium, Bacillus , Enterococcus strains, over treatment periods ranging 4 12 weeks. results showed that reduced lesions, improved barrier function, decreased inflammatory markers. Both balancing reducing severity. Some reported outcomes comparable conventional treatments, benzoyl peroxide. However, there variability individual responses different probiotic effects, though rare, have been some cases. Probiotics presented natural, effective future needed determine optimal protocols. Keywords: microbiome, vulgaris, bacterial imbalance, conditions

Language: Английский

Citations

0
Bidirectional Mendelian Randomization Analysis to Study the Relationship Between Human Skin Microbiota and Radiation-Induced Skin Toxicity DOI Creative Commons
Hui Chen, Xiaojie Xia,

Kexin Shi

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 194 - 194

Published: Jan. 17, 2025

Radiation-induced skin toxicity, resulting from ionizing or nonionizing radiation, is a common disorder. However, the underlying relationship between microbiota and radiation-induced toxicity remains largely unexplored. Herein, we uncover microbiota–skin interaction based on genome-wide association study (GWAS) featuring 150 three types of microenvironment. Summary datasets human were extracted GWAS catalog database, summary FinnGen biobank. Mendelian Randomization (MR) analysis was leveraged to sort out causal link toxicity. We identified 33 connections including 19 positive 14 negative causative directions. Among these potential associations, genus Staphylococcus could serve as risk factor for especially radiodermatitis. And Streptococcus salivarius protective against Additional indicated no pleiotropy, heterogeneity, reverse in results. comprehensively assessed associations with several suggestive links. Our results provide promising targets prevention treatment

Language: Английский

Citations

0
Exploring the Immunological Role of the Microbial Composition of the Appendix and the Associated Risks of Appendectomies DOI Open Access
Tarequl Islam, Md Shahjalal Sagor,

Noshin Tabassum Tamanna

et al.

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(3), P. 112 - 112

Published: March 14, 2025

The appendix, an integral part of the large intestine, may serve two purposes. First all, it is a concentration lymphoid tissue that resembles Peyer’s patches. It also main location in body for creation immunoglobulin A (IgA), which essential controlling intestinal flora’s density and quality. Second, appendix constitutes special place commensal bacteria because its form. Inflammation brought on by variety infectious agents, including bacteria, viruses, or parasites, known as appendicitis. According to number studies, consequences appendectomies be more subtle, relate emergence heart disease, inflammatory bowel disease (IBD), Parkinson’s (PD), among other unexpected illnesses. poorer prognosis recurrent Clostridium difficile infection predicted absence appendix. Appendectomies result gut dysbiosis, consequently causes different outcomes. In this review, we compared compositional differences between microbiome, immunological role microbiome (AM), discussed how appendectomy linked consequences.

Language: Английский

Citations

0
Prospective Comparative Study of an Oral Synbiotic and a Myoinositol-Based Herbal Supplement in Modifying Hormone Levels and the Gut Microbiome in Non-cystic Acne DOI Creative Commons
Mildred Min,

Nasima Afzal,

Jessica Maloh

et al.

Dermatology and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Language: Английский

Citations

0
Microbiome Modulation: Probiotics, Prebiotics, and Postbiotics in Acne Vulgaris Therapy DOI
Nereen A. Almosilhy,

Esraa M. AlEdani

Updates in clinical dermatology, Journal Year: 2025, Volume and Issue: unknown, P. 55 - 81

Published: Jan. 1, 2025

Language: Английский

Citations

0
The Role of Bile Acid in Immune‐Mediated Skin Diseases DOI

Huike Ma,

Ruonan Li,

Baoquan Qu

et al.

Experimental Dermatology, Journal Year: 2025, Volume and Issue: 34(5)

Published: April 29, 2025

ABSTRACT Immune‐mediated skin disorders arise from dysfunctional immune responses, instigating inflammatory dermatoses and a reduced quality of life. The complex pathogenesis likely involves genetic risks, environmental triggers aberrant activation. An emerging body evidence suggests that bile acid disturbances may critically promote pathology in certain conditions. Bile acids synthesised cholesterol regulate nutrient metabolism cell function via nuclear receptors G protein‐coupled (GPCRs). Altered profiles receptor expression have been identified psoriasis, atopic dermatitis (AD) autoimmune blistering diseases. Disruptions signalling affect the metabolic pathways linked to these disorders. Targeting components axis represents promising therapeutic strategy. This review elucidates intricate links between homeostasis dysfunction diseases, synthesising targeting unlock innovative avenues. study compiles clinical experimental data revealing disrupted composition various immune‐mediated dermatoses, highlighting significance cutaneous regulation.

Language: Английский

Citations

0
The Effect of an Oral Probiotic Mixture on Clinical Evolution and the Gut and Skin Microbiome in Patients with Alopecia Areata: A Randomized Clinical Trial DOI Creative Commons

María Rogelia Navarro‐Belmonte,

Ángel Aguado-García, Pedro Sánchez-Pellicer

et al.

Cosmetics, Journal Year: 2024, Volume and Issue: 11(4), P. 119 - 119

Published: July 13, 2024

(1) Background: Given the autoimmune nature of Alopecia Areata (AA) and immunomodulatory properties probiotics, this trial was conducted to evaluate efficacy a probiotic mixture, consisting Lactobacillus rhamnosus Bifidobacterium longum strains, as an adjuvant treatment in group AA patients. (2) Method: This study 24-week, randomized, double-blind, placebo-controlled clinical trial. Twenty-six patients with were included study, their progression, along changes gut skin microbiota, analyzed. (3) Results: A higher proportion treated formula showed improvement compared placebo group, based on both reduction number plaques (56% vs. 30%) affected scalp surface area (45% 20%). For “activity”, “inactivity”, “regrowth”, 55%, 67%, 55% was, respectively, observed 50%, 40%, 30% group. No microbiota during intervention period. Regarding detected reductions characteristic genera study. (4) Conclusions: To our knowledge, is first assessing product AA. mixture routine practice setting appears improve course In addition, lesions modified using treatment.

Language: Английский

Citations

1
THE STUDY OF EFFECT PROBIOTIC IN ACNE AND ROSACEA : A SYSTEMATIC REVIEW DOI Creative Commons

Novitafalen,

Nathania Christika,

Henyta Henyta

et al.

Journal of Advance Research in Medical & Health Science (ISSN 2208-2425), Journal Year: 2024, Volume and Issue: 10(5), P. 166 - 173

Published: May 22, 2024

Background: Alternative remedies have long been utilized by patients to treat skin diseases in addition or instead of traditional medical care. Research on the relationship between probiotics, microbiota, and inflammatory dermatoses is only getting started. Aims : This systematic review association probiotic its effect acne rosacea. Methods: study demonstrated compliance with all requirements means a comparison standards established Preferred Reporting Items for Systematic Review Meta-Analysis (PRISMA) 2020. Thus, specialists were able guarantee that research was as current feasible. Publications released 2014 2024 considered this search strategy. accomplished utilizing number distinct online reference sites, including Pubmed, ScienceDirect, SagePub. It determined reviews, previously published works, partially completed works would not be included. Result: In PubMed database, results our brought up 19 articles, whereas SCIENCE DIRECT 166 SAGEPUB 10 articles. The conducted last year yielded total 18 articles PubMed, 122 7 SAGEPUB. end, we compiled 6 papers, 3 which came from 2 1 We included six met criteria. Conclusion: summary, manyof studies are currently available literature involved limited patients, did state species dosage probiotics utilized, run their trials enough fully assess effects microbiome stomach.

Language: Английский

Citations

0
Skin Microbiome and Acne: Microbial Imbalances and Impact – Interview with Three Key Opinion Leaders DOI Creative Commons

Brigitte Scott

EMJ Dermatology, Journal Year: 2024, Volume and Issue: unknown, P. 83 - 94

Published: Nov. 7, 2024

Acne vulgaris, commonly known as acne, is a multifactorial, chronic inflammatory skin condition involving the pilosebaceous unit, and one of most common diseases globally. significantly impacts quality life wellbeing patients, can be associated with anxiety, depression, low self-esteem. This also substantial healthcare costs economic burden for society. The treatment acne complex challenging. For this article, EMJ conducted an interview in September 2024 key opinion leaders Marco Rocha from Federal University São Paulo, Brazilian Society Dermatology, Brazil; Thomas Dirschka CentroDerm Clinic, Wuppertal, Witten-Herdecke, Germany; Alison Layton Skin Research Centre, Hull York Medical School, York, Harrogate District NHS Foundation Trust, UK. leaders, who have wealth experience expertise clinical management were asked about current landscape potential role microbiome development disease. experts provided valuable insights into some many unmet needs management, particularly overuse antibiotics lack effective alternative therapies condition. discussed contribution microbial imbalances prebiotics probiotics restoring health. concept integrating microbiome-modulating strategies conventional treatment, whether there connection between psychological conditions such considered. A further topic covered was educating patients parents acne. Finally, outlined what future might look like.

Language: Английский

Citations

0