Drivers and mechanisms of cognitive decline in chronic kidney disease

Nature Reviews Nephrology, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Language: Английский

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The impact of chronic kidney disease on cognitive function

Current Opinion in Nephrology & Hypertension, Journal Year: 2024, Volume and Issue: 33(6), P. 566 - 572

Published: Aug. 12, 2024

Purpose of review The risk cognitive impairment is higher in people with CKD than the general population. complex relationship between and dysfunction has not been extensively characterized. Here, we epidemiological associations, specific patterns CKD-related impairment, underlying mechanisms, recently published data on relevant biomarkers. Recent findings Despite some discrepancies, recent studies have confirmed that associated function (e.g. incident events). Although patients often exhibit impairments executive functions attention, it noteworthy other memory) can be preserved. key mechanisms described include vascular damage, genetic factors, accumulation uremic toxins, disruption blood–brain barrier, glymphatic system dysfunction, changes gut–brain axis. Kidney increasingly seen as a game changer interpretation biomarkers and, especially, hallmarks Alzheimer disease. Summary reviewed here highlight need for interdisciplinary collaboration nephrologists neurologists care at impairment. In order to further improving diagnosis therapy, future research must elucidate CKD–cognitive association confirm value

Language: Английский

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Cognitive Impairment Related to Chronic Kidney Disease Is Associated with a Decreased Abundance of Membrane-Bound Klotho in the Cerebral Cortex

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4194 - 4194

Published: April 10, 2024

Cognitive impairment (CI) is a complication of chronic kidney disease (CKD) that frequently observed among patients. The aim this study was to evaluate the potential crosstalk between changes in cognitive function and levels Klotho brain cortex an experimental model CKD. To induce renal damage, Wistar rats received diet containing 0.25% adenine for six weeks, while control group fed standard diet. animals underwent different tests assessment function. At sacrifice, parameters mineral metabolism expression frontal were evaluated. with CKD exhibited impaired behavior comparison normal CKD-associated disorder confirmed by presence expected disturbances plasma phosphorus, PTH, both intact c-terminal FGF23, along reduced abundance Klotho. Interestingly, marked significant decrease cerebral dysfunction. In sum, loss may contribute dysfunction Although further studies are required, might have relevant role development CI represent target management complication.

Language: Английский

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AST-120 Protects Cognitive and Emotional Impairment in Chronic Kidney Disease Induced by 5/6 Nephrectomy

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 1043 - 1043

Published: Oct. 22, 2024

Uremic toxins resulting from chronic kidney disease (CKD) can cause cognitive and emotional disorders, as well cardiovascular diseases. Indoxyl sulfate (IS) p-cresol are notable uremic found in patients with CKD. However, few studies have investigated whether reducing alleviate disorders associated

Language: Английский

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