Prevalence, incidence, and mortality rates of breast cancer in Kazakhstan: data from the Unified National Electronic Health System, 2014–2019
Frontiers in Public Health,
Journal Year:
2023,
Volume and Issue:
11
Published: April 17, 2023
Background
Although
there
are
numerous
sources
of
epidemiologic
information
on
breast
cancer
in
Kazakhstan,
none
them
have
specifically
examined
the
burden
this
disease.
Therefore,
article
aims
to
provide
an
overview
prevalence,
incidence,
mortality,
and
distribution
changes
over
time
Kazakhstan
based
nationwide
large-scale
healthcare
data
from
National
Registry
order
encourage
more
research
impact
various
diseases
at
regional
national
levels.
Methods
The
study
cohort
included
all
adult
women
older
than
25
years
who
were
diagnosed
with
any
clinical
setting
Republic
during
period
2014–2019.
extracted
Unified
Nationwide
Electronic
Health
System
(UNEHS)
get
descriptive
statistics,
mortality
rate
calculations
Cox
proportional
hazards
regression
model.
All
survival
functions
factors
associated
tested
for
significance.
Results
population
(
n
=
55,465)
comprised
subjects
age
diagnosis
97
years,
a
mean
55.7
±
12.0
years.
majority
belonged
group
45–59
which
is
44.8%
cohort.
all-cause
16%.
prevalence
increased
30.4
per
10,000
2014
50.6
2019.
incidence
varied
4.5
2015
7.3
2016.
Mortality
rates
stable
high
senile
patients
(75–89
old).
Breast
was
positively
had
been
diabetes,
HR
1.2
(95%
CI,
1.1–2.3),
whereas
it
negatively
arterial
hypertension,
0.4
0.4–0.5).
Conclusion
Overall,
experiencing
increase
cases,
but
has
started
decline.
switch
mammography
screening
could
reduce
rate.
These
findings
should
be
utilized
help
determine
what
control
priorities
utilized,
including
need
implement
efficient
affordable
prevention
programs.
Language: Английский
Early Diagnosis of Chemotherapy-Linked Cardiotoxicity in Breast Cancer Patients Using Conventional Biomarker Panel: A Prospective Study Protocol
Diagnostics,
Journal Year:
2022,
Volume and Issue:
12(11), P. 2714 - 2714
Published: Nov. 6, 2022
The
prognosis
of
cancer
treatment
depends
on,
among
other
aspects,
the
cardiotoxicity
chemotherapy.
This
research
aims
to
create
a
feasible
algorithm
for
early
diagnosis
antitumor
therapy
in
breast
patients.
paper
represents
protocol
prospective
cohort
study
with
N
120
eligible
participants
admitted
anthracyclines
and/or
trastuzumab.
These
patients
will
be
allocated
into
four
risk
groups
regarding
potential
cardiotoxic
complications.
Patients
examined
five
times
every
three
months
six
biomarkers,:
cardiac
troponin
I
(cTnI),
brain
natriuretic
peptide
(BNP),
C-reactive
protein
(CRP),
myeloperoxidase
(MPO),
galectin-3
(Gal-3),
and
D-dimer,
simultaneously
echocardiographic
methods,
including
speckle
tracking.
adjusted
relative
(aOR)
interrupting
an
entire
course
chemotherapy
due
events
assessed
using
multiple
analyses
proportional
Cox
risks.
model
also
assess
associations
between
baseline
biomarker
values
time
events.
Moreover,
partly
conditional
survival
models
applied
determine
repeated
assessments
changes
biomarkers
from
therapy-related
dysfunction.
All
regimen,
LVEF,
at
risk,
values,
age.
decision-tree
principal
component
analysis
(PCA)
methods
applied.
Thus,
patterns
detected.
Language: Английский