Reduced DTI-ALPS in H-type hypertension: insights into perivascular space function DOI Creative Commons
Chun Zhang, Caihong Song, Shiying Sheng

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: April 4, 2025

Recent studies suggest that glymphatic dysfunction plays a significant role in vascular cognitive impairment (VCI). Both hypertension and hyperhomocysteinemia are independent risk factors for VCI, their combination is referred to as H-type (HHT). However, the impact of HHT on function remains unclear. This study used recently popular indirect marker, diffusion tensor imaging along perivascular space (DTI-ALPS) assess potential changes patients with HHT. We recruited 58 50 healthy controls without hypertension, collecting clinical, cognitive, biochemical, MRI data. Behaviorally, scored lower global tests compared controls. DTI-ALPS analysis revealed bilateral reduction patients. Correlation showed strong associations between values, reduced scores, elevated homocysteine (Hcy) levels Mediation further indicated largely mediates relationship Hcy performance. These findings contribute reduction, which may underlie decline observed

Language: Английский

Emerging non-invasive MRI techniques for glymphatic system assessment in neurodegenerative disease DOI
D. Botta,

Ioana Hutuca,

Elyas El Ghoul

et al.

Journal of Neuroradiology, Journal Year: 2025, Volume and Issue: 52(3), P. 101322 - 101322

Published: Jan. 31, 2025

Language: Английский

Citations

3
Glymphatic system dysfunction in epilepsy related to focal cortical dysplasia and its relationship with antiseizure medication response DOI
Bo Jin,

Jiahui Xu,

Jing Hu

et al.

Seizure, Journal Year: 2025, Volume and Issue: 125, P. 31 - 36

Published: Jan. 1, 2025

Language: Английский

Citations

1
Effects of sleep on the glymphatic functioning and multimodal human brain network affecting memory in older adults DOI Creative Commons

Junji Ma,

Menglu Chen, Geng-Hao Liu

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Understanding how sleep affects the glymphatic system and human brain networks is crucial for elucidating neurophysiological mechanism underpinning aging-related memory declines. We analyzed a multimodal dataset collected through magnetic resonance imaging (MRI) polysomnographic recording from 72 older adults. A proxy of functioning was obtained Diffusion Tensor Image Analysis along Perivascular Space (DTI-ALPS) index. Structural functional were constructed based on MRI data, coupling between two (SC-FC coupling) also calculated. Correlation analyses revealed that DTI-ALPS negatively correlated with quality measures [e.g., Pittsburgh Sleep Quality Index (PSQI) apnea-hypopnea index]. Regarding networks, associated strength both connectivity (FC) structural (SC) involving regions such as middle temporal gyrus parahippocampal gyrus, well SC-FC rich-club connections. Furthermore, we found positively mediated association coupling. The further function in good sleepers but not poor sleepers. results suggest disrupted glymphatic-brain relationship sleepers, which underlies decline. Our findings add important evidence cognitive health underlying neural relationships interplay networks.

Language: Английский

Citations

8
DTI-ALPS index decreased in patients with Type 2 Diabetes Mellitus DOI Creative Commons

Shuncheng Yu,

Jiang Hongjun,

Langxuan Yu

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: May 22, 2024

Backgrounds Type 2 Diabetes Mellitus (T2DM) has become a significant global public health issue, characterized by rising prevalence and associated deficits across multiple organ systems. Our study aims to utilize the DTI-ALPS technique assess change of ALPS index in T2DM patients, explore whether such changes are correlated with cognition level diffusion parameters. Methods The involved 41 patients (mean age, 60.49 ± 8.88 years) 27 healthy controls 58.00 7.63 years). All subjects underwent MRI examination, cognitive assessment, laboratory tests. Tract-based spatial statistics (TBSS) was used evaluate white matter changes. GLM performed check difference between HC groups. Spearman correlation analysis partial were analyze properties & scores. Results results show that lower patients. MoCA score significantly index. Patients had increase both mean diffusivity (MD) radial (RD) decrease fractional anisotropy (FA) compared group. Conclusion suggest is decreased associates level.

Language: Английский

Citations

6
Diffusion tensor imaging analysis along the perivascular space in the UK biobank DOI Creative Commons
Oliver James Clark, Ariane Delgado‐Sanchez, Natàlia Cullell

et al.

Sleep Medicine, Journal Year: 2024, Volume and Issue: 119, P. 399 - 405

Published: May 3, 2024

The recently discovered glymphatic system may support the removal of neurotoxic proteins, mainly during sleep, that are associated with neurodegenerative diseases such as Alzheimer's and Parkinson's Disease. Diffusion tensor image analysis along perivascular space (DTI-ALPS) has been suggested a method to index health (with higher values indicating more intact system). Indeed, in small-scale studies DTI-ALPS shown correlate age, cognitive health, is females than males. To determine whether these relationships stable we replicated previous findings associating demographic, sleep-related, markers large sample participants from UK Biobank. We calculated Biobank (n = 17723). Using Bayesian Frequentist approaches, replicate previously reported between index. found predicted associations longest uninterrupted sleep window (LUSWT) on typical night, performance, sex. However, effects were substantially smaller those studies. Parameter estimates this study be used priors subsequent using approach. These results suggest consistently, therefore predictably, demographics, LUWST, cognition. propose metric, for first time large-scale, population-based cohort, measure, but one which stronger links function needed before it can understand outcomes UKBiobank.

Language: Английский

Citations

4
Evaluating the glymphatic system via magnetic resonance diffusion tensor imaging along the perivascular spaces in brain tumor patients DOI Creative Commons

Gabriela Villacis,

Aileen Schmidt,

Justus Christian Rudolf

et al.

Japanese Journal of Radiology, Journal Year: 2024, Volume and Issue: 42(10), P. 1146 - 1156

Published: May 31, 2024

Abstract Purpose To investigate glymphatic system function in patients with brain tumors, including both primary and secondary using diffusion tensor imaging along perivascular spaces (DTI-ALPS). Methods We retrospectively analyzed the MR DTI of 24 unilateral tumors compared them age sex-matched controls. DTI-ALPS index ipsi- contralateral hemispheres. The region interest was placed periventricular vessels adjacent to lateral ventricles. Differences between sex, age, kind tumor (primary or metastasis) were evaluated. Correlations tumor's apparent coefficient (ADC) also investigated. Results significantly lower ( p < 0.05) tumor-affected hemisphere (mean = 1.26 ± 0.24) than 1.43 0.28). A comparison healthy controls revealed no significant difference on matched ipsilateral side. However, side larger HC. Additionally, statistically differences found when analyzing vs. entity. we did not find a correlation patient ADC. Conclusion decreased may be related impaired function. cancer is often systemic disease; thus, from generally considered as normal control. Nonetheless, does only reflect but it can influenced by factors such axonal degeneration. Therefore, directly waste clearance changes should interpreted carefully.

Language: Английский

Citations

4
Glymphatic function assessment with diffusion tensor imaging along the perivascular space in patients with major depressive disorder and its relation to cerebral white-matter alteration DOI Open Access
Chun Yang,

Shiyun Tian,

Wei Du

et al.

Quantitative Imaging in Medicine and Surgery, Journal Year: 2024, Volume and Issue: 14(9), P. 6397 - 6412

Published: Aug. 22, 2024

The link between glymphatic system function in the brain and alterations white-matter microstructure among individuals with major depressive disorder (MDD) remains unclear. This study aimed to examine assessment of patients MDD using diffusion tensor imaging along perivascular space (DTI-ALPS) index evaluate its association cerebral-white-matter abnormalities neuropsychological scores.

Language: Английский

Citations

4
Glymphatic system impairment in normal tension glaucoma evaluated by diffusion tensor image analysis along the perivascular space DOI
Ting Li, Qian Wang, B.T. Yang

et al.

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149450 - 149450

Published: Jan. 1, 2025

Language: Английский

Citations

0
Genome-wide association study unravels mechanisms of brain glymphatic activity DOI Creative Commons

Shu‐Yi Huang,

Yi‐Jun Ge,

Peng Ren

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 13, 2025

Language: Английский

Citations

0
Glymphatic defect in isolated REM sleep behavior disorder is associated with phenoconversion to Parkinson's disease DOI

Violette Ayral,

Alexandre Pastor‐Bernier, Véronique Daneault

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Abstract Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is characterized by the loss of muscle atonia and abnormal, often violent, movements vocalizations during REM sleep. It strongest prodromal marker for progression to synucleinopathies such as dementia with Lewy bodies (DLB) Parkinson’s disease (PD). iRBD individuals already show brain changes consistent manifest synucleinopathies, but their mechanisms remain poorly understood. The glymphatic system involved in clearance waste products its defect has been associated a higher likelihood pathological burden neurodegeneration. presence dysfunction revealed neuroimaging association uninvestigated, including potential predict conversion toward distinct trajectories synucleinopathies. We analyzed diffusion-weighted imaging data from large international multicentric cohort polysomnography-confirmed healthy controls. used diffusion tensor along perivascular space assess function derived index based on diffusivity occurring within masks placed associative projection fibers adjacent lateral ventricles. was compared between groups correlated motor cognitive features. Cox regression models assessed relationship PD, DLB or remaining disease-free. Our analyses included 250 participants (mean age 66.5 ± 6.8 years; 87% men) 178 controls (65.7 81% men). There significantly reduced Among 224 followed longitudinally (6.1 years, 1-16 years), 65 developed neurodegenerative disease. converters exhibited lower non-converters. Lower risk phenoconversion towards PD over time disease-free (hazard ratio = 2.43, 95% CI 1.13-5.25, P 0.012). This study reports predicting underscoring utility identifying at-risk individuals.

Language: Английский

Citations

0