Heterozygosity-Rich Regions in Canine Genome: Can They Serve as Indicators of Balancing Selection? DOI Creative Commons
Adrián Halvoník, Nina Moravčí­ková, L. Vostrý

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(4), P. 612 - 612

Published: Feb. 19, 2025

Compared to the negative effect of directional selection on genetic diversity, balancing acts oppositely and maintains variability across genome. This study aims articulate whether leads heterozygosity-rich region islands (HRRIs) forming in canine genome by investigating 1000 animals belonging 50 dog breeds via 153,733 autosomal SNPs. A consecutive SNP-based approach was used identify regions (HRRs). Signals studied were then assessed with Tajima's D statistics. total 72,062 HRRs an average length 324 kb detected be unevenly distributed 509 450 genomic classified as HRRIs signals, respectively. Although genome-wide distributions varied breeds, several found same locations multiple breeds. 109 both signals selection. Even though coordinates did not fully overlap all regions, may play a significant role maintaining diversity associated various cancer diseases, immune response, bone, skin, cartilage tissue development.

Language: Английский

Heterozygosity-Rich Regions in Canine Genome: Can They Serve as Indicators of Balancing Selection? DOI Creative Commons
Adrián Halvoník, Nina Moravčí­ková, L. Vostrý

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(4), P. 612 - 612

Published: Feb. 19, 2025

Compared to the negative effect of directional selection on genetic diversity, balancing acts oppositely and maintains variability across genome. This study aims articulate whether leads heterozygosity-rich region islands (HRRIs) forming in canine genome by investigating 1000 animals belonging 50 dog breeds via 153,733 autosomal SNPs. A consecutive SNP-based approach was used identify regions (HRRs). Signals studied were then assessed with Tajima's D statistics. total 72,062 HRRs an average length 324 kb detected be unevenly distributed 509 450 genomic classified as HRRIs signals, respectively. Although genome-wide distributions varied breeds, several found same locations multiple breeds. 109 both signals selection. Even though coordinates did not fully overlap all regions, may play a significant role maintaining diversity associated various cancer diseases, immune response, bone, skin, cartilage tissue development.

Language: Английский

Citations

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