The impact of ivermectin-loaded solid lipid nanoparticles on the enteric phase of experimental trichinellosis DOI
Samar Kamel Hammad,

Mona Almotayam,

Asmaa Mohamed

et al.

Journal of Helminthology, Journal Year: 2025, Volume and Issue: 99

Published: Jan. 1, 2025

Abstract Trichinellosis is a global zoonotic disease affecting humans and nearly all animal species. The intestinal (enteric) phase of trichinellosis critical, as it determines the course prognosis disease. medications used in management demonstrate inadequate bioavailability, along with significant level resistance. Therefore, there need for development novel agents that enhance bioavailability administered medications. Nanobiotechnology has emerged strategy treating parasitic diseases. This study examined use solid lipid nanoparticles (SLNs) to improve efficacy oral ivermectin (IVM) enteric trichinellosis. Thirty-five Swiss albino mice were divided into seven equal groups follows: negative control, positive albendazole, ivermectin, SLNs, loaded on (IVM-SLNs), combination IVM-SLNs albendazole. Mice sacrificed seventh day post-infection. drugs’ effects assessed using parasitological, biochemical, histological, histochemical immunohistochemical analyses. co-administration albendazole resulted decrease adult burden, inflammatory cell infiltration, apoptosis. Furthermore, reduction Cyclooxygenase-2 (COX-2) expression was observed compared infected untreated control group, improved liver kidney function indices. In conclusion, potent trichinocidal effect single dose against Trichinella adults makes them promising alternative or adjunct existing nematicidal agents.

Language: Английский

The impact of ivermectin-loaded solid lipid nanoparticles on the enteric phase of experimental trichinellosis DOI
Samar Kamel Hammad,

Mona Almotayam,

Asmaa Mohamed

et al.

Journal of Helminthology, Journal Year: 2025, Volume and Issue: 99

Published: Jan. 1, 2025

Abstract Trichinellosis is a global zoonotic disease affecting humans and nearly all animal species. The intestinal (enteric) phase of trichinellosis critical, as it determines the course prognosis disease. medications used in management demonstrate inadequate bioavailability, along with significant level resistance. Therefore, there need for development novel agents that enhance bioavailability administered medications. Nanobiotechnology has emerged strategy treating parasitic diseases. This study examined use solid lipid nanoparticles (SLNs) to improve efficacy oral ivermectin (IVM) enteric trichinellosis. Thirty-five Swiss albino mice were divided into seven equal groups follows: negative control, positive albendazole, ivermectin, SLNs, loaded on (IVM-SLNs), combination IVM-SLNs albendazole. Mice sacrificed seventh day post-infection. drugs’ effects assessed using parasitological, biochemical, histological, histochemical immunohistochemical analyses. co-administration albendazole resulted decrease adult burden, inflammatory cell infiltration, apoptosis. Furthermore, reduction Cyclooxygenase-2 (COX-2) expression was observed compared infected untreated control group, improved liver kidney function indices. In conclusion, potent trichinocidal effect single dose against Trichinella adults makes them promising alternative or adjunct existing nematicidal agents.

Language: Английский

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