Neutrophil-to-lymphocyte ratio as a prognostic biomarker in patients with peripheral artery disease: A systematic review and meta-analysis

Vascular Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Background: The neutrophil-to-lymphocyte ratio (NLR) is a simple and routinely obtained parameter reflecting systemic inflammation, including in peripheral artery disease (PAD). Methods: This systematic review aimed to assess the role of NLR as prognostic biomarker patients with PAD. A search was conducted across PubMed, ScienceDirect, Web Science, Scopus, ProQuest, EBSCO, Cochrane. Random-effects meta-analysis used pool risk ratios, sensitivity, specificity, positive predictive value (PPV), negative (NPV). bivariate model generate summary receiver operating characteristics corresponding area under curve (AUC). Results: included 5243 PAD from nine eligible studies. High corresponded at least twofold increased all-cause mortality (ACM), major adverse limb events (MALE), cardiovascular (MACE). NLR’s performance good for predicting 1-year ACM (AUC 0.71 [95% CI: 0.59–0.79], sensitivity 58.2% 45.3–71.0], specificity 72.6% 65.6–79.62], PPV 41.0% 31.2–50.7], NPV 82.7% 74.1–91.3]) MALE 0.78 0.75–0.80], 65.4% 41.6–89.2], 77.7% 71.0–84.3], 53.7% 47.3–60.1], 83.91% 73.2–94.6]). However, these values tended decrease follow-up duration extended, except pooled specificities, which exhibited opposite pattern. Conclusion: emerges cost-effective decent poor outcomes (PROSPERO Registration No.: CRD42023486607).

Language: Английский

Intimal CD31-Positive Relative Surfaces Are Associated with Systemic Inflammatory Markers and Maturation of Arteriovenous Fistula in Dialysis Patients

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(13), P. 4419 - 4419

Published: June 30, 2023

Background: Arteriovenous fistula dysfunction is a widely disputed subject in the scientific literature on end-stage kidney disease (ESKD). The main cause of mortality and morbidity these patients non-maturation or arteriovenous fistula. Despite many complications, native remains gold standard treatment requiring renal replacement. This study aims to discuss predictive role some systemic inflammatory biomarkers (NLR, PLR, SII, IL-6), intimal hyperplasia, neoangiogenesis (characterized by intimal-media CD31-positive relative surface) maturation failure. Methods: present was designed as an observational, analytical, prospective which included diagnosed with ESKD indications radio-cephalic (RCAVF). Demographic data, comorbidities, preoperative laboratory data histological/digital morphometry analysis results were processed. divided into two groups based their AVF status at 8 weeks: “Maturation” (Group 1) “Failed Maturation” 2). Results: There no difference demographic data. In terms second group had greater incidence heart failure (p = 0.03), diabetes 0.04), peripheral artery 0.002), obesity 0.01). Additionally, regarding findings, higher levels serum uric acid 0.0005), phosphates < 0.0001), creatinine 0.02), well lower total calcium 0.0002), monocytes 0.008), lymphocytes 0.0001). Moreover, all markers 0.001; p 0.0001; 0.006, 0.03) Ca-P product 0.0001) baseline values Group 2. Upon immunohistochemical analysis, density neoformed vessels, there surfaces 0.006) 0.001); NLR (r 0.323; PLR 0.381; SII 0.376; IL-6 0.611; 0.001) are significantly correlated vascular density, evidenced CD31. Conclusions: Heart failure, disease, obesity, diabetes, predictors failures.

Language: Английский

Prognostic value of leukocyte-glycemic index in long-term evolution of diabetic patients with peripheral arterial disease following endovascular treatment

Acta Marisiensis. Seria Medica, Journal Year: 2024, Volume and Issue: 70(2), P. 58 - 63

Published: June 1, 2024

Abstract Objective : The aim of this article is to determine the predictive value leukocyte-glycemic index in long-term evolution diabetic patients with peripheral arterial disease following endovascular treatment. Methods This retrospective observational study enrolled 127 diagnosed requiring Patients were categorized into two groups based on severity infrapopliteal atherosclerotic lesions identified during pre-operative Computer Tomography Angiography examination. Group 1 includes without severe damage artery, while 2 artery damage, by stenosis greater than 70% all arteries. primary outcome was assess association between at baseline and major amputation after percutaneous transluminal angioplasty. Results had a higher incidence cardiovascular events (p=0.009), stage IV Leriche-Fontaine (p=0.016), (p<0.001), as well an increased (p=0.004). During follow-up, above-median have risk (p=0.034), seen Kaplan-Meier analysis. Moreover, cox-regression, elevated biomarker values associated amputation, independent age, sex, factors, below-the-knee occlusion (HR:2.69, p=0.001). Conclusions Elevated are long term.

Language: Английский