Genome biology,
Journal Year:
2023,
Volume and Issue:
24(1)
Published: Sept. 11, 2023
Abstract
Growing
regulatory
requirements
set
barriers
around
genetic
data
sharing
and
collaborations.
Moreover,
existing
privacy-aware
paradigms
are
challenging
to
deploy
in
collaborative
settings.
We
present
COLLAGENE,
a
tool
base
for
building
secure
genomic
analysis
methods.
COLLAGENE
protects
using
shared-key
homomorphic
encryption
combines
with
multiparty
strategies
efficient
method
development.
provides
ready-to-run
tools
encryption/decryption,
matrix
processing,
network
transfers,
which
can
be
immediately
integrated
into
pipelines.
demonstrate
the
usage
of
by
practical
federated
GWAS
protocol
binary
phenotypes
meta-analysis
protocol.
is
available
at
https://zenodo.org/record/8125935
.
Federated
learning
(FL)
is
an
emerging
distributed
machine
paradigm
which
addresses
critical
data
privacy
issues
in
by
enabling
clients,
using
aggregation
server
(aggregator),
to
jointly
train
a
global
model
without
revealing
their
training
data.
Thereby,
it
improves
not
only
but
also
efficient
as
uses
the
computation
power
and
of
potentially
millions
clients
for
parallel.
However,
FL
vulnerable
so-called
inference
attacks
malicious
aggregators
can
infer
information
about
clients'
from
updates.
Secure
restricts
central
aggregator
learn
summation
or
average
updates
clients.
Unfortunately,
existing
protocols
secure
suffer
high
communication,
computation,
many
communication
rounds.In
this
work,
we
present
SAFELearn,
generic
design
private
systems
that
protects
against
have
analyze
individual
aggregation.
It
flexibly
adaptable
efficiency
security
requirements
various
applications
be
instantiated
with
MPC
FHE.
In
contrast
previous
works,
need
2
rounds
each
iteration,
do
use
any
expensive
cryptographic
primitives
on
tolerate
dropouts,
rely
trusted
third
party.
We
implement
benchmark
instantiation
our
two-party
computation.
Our
implementation
aggregates
500
models
more
than
300K
parameters
less
0.5
seconds.
Nature Communications,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: Oct. 11, 2021
Abstract
Using
real-world
evidence
in
biomedical
research,
an
indispensable
complement
to
clinical
trials,
requires
access
large
quantities
of
patient
data
that
are
typically
held
separately
by
multiple
healthcare
institutions.
We
propose
FAMHE,
a
novel
federated
analytics
system
that,
based
on
multiparty
homomorphic
encryption
(MHE),
enables
privacy-preserving
analyses
distributed
datasets
yielding
highly
accurate
results
without
revealing
any
intermediate
data.
demonstrate
the
applicability
FAMHE
essential
analysis
tasks,
including
Kaplan-Meier
survival
oncology
and
genome-wide
association
studies
medical
genetics.
our
system,
we
accurately
efficiently
reproduce
two
published
centralized
setting,
enabling
insights
not
possible
from
individual
institutions
alone.
Our
work
represents
necessary
key
step
towards
overcoming
privacy
hurdle
multi-centric
scientific
collaborations.
Despite
the
great
potential
and
flexibility
of
smart
contract-enabled
blockchains,
building
privacy-preserving
applications
using
these
platforms
remains
an
open
question.
Existing
solutions
fall
short
since
they
ask
end
users
to
coordinate
perform
computation
off-chain
themselves.
While
such
approach
reduces
burden
miners
system,
it
largely
limits
ability
lightweight
enjoy
privacy
performing
actual
on
their
own
attesting
its
correctness
is
expensive
even
with
state-of-the-art
proof
systems.To
address
this
limitation,
we
propose
smartFHE,
a
framework
support
private
contracts
fully
homomorphic
encryption
(FHE).
To
best
our
knowledge,
smartFHE
first
use
FHE
in
blockchain
model;
moreover,
arbitrary
for
under
same
computation-on-demand
model
pioneered
by
Ethereum.
does
not
overload
user
are
instead
responsible
computation.
This
achieved
employing
so
can
compute
over
encrypted
data
account
balances.
Users
only
proving
well-formedness
inputs
efficient
zero-knowledge
systems
(ZKPs).
We
formulate
notion
contract
(PPSC)
scheme
show
concrete
instantiation
framework.
challenges
resulting
from
setting—including
concurrency
dealing
leveled
schemes.
also
how
choose
suitable
ZKP
schemes
instantiate
framework,
naively
choosing
will
lead
poor
performance
practice.
formally
prove
security
construction.
Finally,
conduct
experiments
evaluate
efficiency,
including
comparisons
testing
several
applications.
have
open-sourced
(highly
optimized)
library,
which
could
be
independent
interest.
Nature Genetics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 24, 2025
Sharing
data
across
institutions
for
genome-wide
association
studies
(GWAS)
would
enhance
the
discovery
of
genetic
variation
linked
to
health
and
disease1,2.
However,
existing
data-sharing
regulations
limit
scope
such
collaborations3.
Although
cryptographic
tools
secure
computation
promise
enable
collaborative
analysis
with
formal
privacy
guarantees,
approaches
either
are
computationally
impractical
or
do
not
implement
current
state-of-the-art
methods4–6.
We
introduce
federated
(SF-GWAS),
a
combination
frameworks
distributed
algorithms
that
empowers
efficient
accurate
GWAS
on
private
held
by
multiple
entities
while
ensuring
confidentiality.
SF-GWAS
supports
widely
used
pipelines
based
principal-component
linear
mixed
models.
demonstrate
accuracy
practical
runtimes
five
datasets,
including
UK
Biobank
cohort
410,000
individuals,
showcasing
an
order-of-magnitude
improvement
in
runtime
compared
previous
methods.
Our
work
enables
genomic
at
unprecedented
scale.
is
workflow
secure,
studies,
implementing
accurate,
privacy-preserving
analysis,
linear/logistic
regression
model
methods
biobank-scale
multisite
analyses.
IEEE Transactions on Circuits and Systems for Video Technology,
Journal Year:
2023,
Volume and Issue:
33(7), P. 3185 - 3198
Published: Jan. 5, 2023
Decentralized
image
classification
plays
a
key
role
in
various
scenarios
due
to
its
attractive
properties,
including
tolerating
high
network
latency
and
less
prone
single-point
failures.
Unfortunately,
training
such
decentralized
model
is
more
vulnerable
data
privacy
leaks
compared
other
distributed
frameworks.
Existing
efforts
exclusively
use
differential
as
the
cornerstone
alleviate
threat
privacy.
However,
implemented
at
expense
of
accuracy,
which
goes
against
our
motivation
for
designing
an
without
loss
accuracy.
To
address
this
problem,
we
propose
D
2
-MHE,
first
secure
efficient
framework
with
lossless
precision.
Inspired
by
latest
developments
homomorphic
encryption
technology,
design
multiparty
version
Brakerski-Fan-Vercauteren
(BFV),
one
most
advanced
cryptosystems,
it
implement
private
gradient
updates
users'
local
models.
-MHE
can
reduce
communication
complexity
general
Secure
Multiparty
Computation
(MPC)
tasks
from
quadratic
linear
number
users,
making
very
suitable
scalable
large-scale
learning
systems.
Moreover,
provides
strict
semantic
security
protection
even
if
majority
users
are
dishonest
collusion.
We
conduct
extensive
experiments
on
MNIST,
CIFAR-10,
ImageNet
demonstrate
superiority
-MHE.
Experimental
results
show
that
achieves
up
$5.5\times
$
reduction
computation
overhead,
least
notation="LaTeX">$12\times
overhead
existing
schemes.
Proceedings of the 2022 ACM SIGSAC Conference on Computer and Communications Security,
Journal Year:
2023,
Volume and Issue:
unknown, P. 726 - 740
Published: Nov. 15, 2023
Homomorphic
Encryption
(HE)
is
a
cryptosytem
that
allows
us
to
perform
an
arbitrary
computation
on
encrypted
data.
The
standard
HE,
however,
has
disadvantage
in
the
authority
concentrated
secret
key
owner
since
computations
can
only
be
performed
ciphertexts
under
same
key.
To
resolve
this
issue,
research
underway
Multi-Key
(MKHE),
which
variant
of
HE
supporting
possibly
different
keys.
Despite
its
ability
provide
privacy
for
multiple
parties,
existing
MKHE
schemes
suffer
from
poor
performance
due
cost
multiplication
grows
at
least
quadratically
with
number
keys
involved.
Journal of Cryptology,
Journal Year:
2023,
Volume and Issue:
36(2)
Published: March 22, 2023
Abstract
We
propose
and
implement
a
multiparty
homomorphic
encryption
(MHE)
scheme
with
$$t$$
t
-out-of-
$$N$$
N
-threshold
access-structure
that
is
efficient
does
not
require
trusted
dealer
in
the
common
random
string
model.
construct
this
from
ring-learning-with-error
assumptions
as
an
extension
of
MHE
Mouchet
et
al.
(PETS
21).
By
means
specially
adapted
share
re-sharing
procedure,
can
be
used
to
relax
original
into
one.
This
procedure
introduces
only
single
round
communication
during
setup
phase,
after
which
any
set
at
least
t
parties
compute
additive
sharing
secret-key
no
interaction;
new
directly
show
that,
by
performing
Shamir
over
ciphertext-space
ring
carefully
chosen
exceptional
set,
reconstruction
made
secure
has
negligible
overhead.
Moreover,
it
requires
store
constant-size
state
its
phase.
Hence,
addition
fault
tolerance,
lowering
corruption
threshold
also
yields
considerable
efficiency
benefits,
enabling
distribution
batched
operations
among
online
parties.
implemented
open-sourced
our
Lattigo
library.
2022 IEEE Symposium on Security and Privacy (SP),
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 1, 2023
Principal
component
analysis
(PCA)
is
an
essential
algorithm
for
dimensionality
reduction
in
many
data
science
domains.
We
address
the
problem
of
performing
a
federated
PCA
on
private
distributed
among
multiple
providers
while
ensuring
confidentiality.
Our
solution,
SF-PCA,
end-to-end
secure
system
that
preserves
confidentiality
both
original
and
all
intermediate
results
passive-adversary
model
with
up
to
all-but-one
colluding
parties.
SF-PCA
jointly
leverages
multiparty
homomorphic
encryption,
interactive
protocols,
edge
computing
efficiently
interleave
computations
local
cleartext
operations
collectively
encrypted
data.
obtains
as
accurate
non-secure
centralized
solutions,
independently
distribution
It
scales
linearly
or
better
dataset
dimensions
number
providers.
more
precise
than
existing
approaches
approximate
solution
by
combining
results,
between
3x
250x
faster
privacy-preserving
alternatives
based
solely
computation
encryption.
work
demonstrates
practical
applicability
datasets.
Patterns,
Journal Year:
2022,
Volume and Issue:
3(5), P. 100487 - 100487
Published: April 18, 2022
Training
accurate
and
robust
machine
learning
models
requires
a
large
amount
of
data
that
is
usually
scattered
across
silos.
Sharing
or
centralizing
the
different
healthcare
institutions
is,
however,
unfeasible
prohibitively
difficult
due
to
privacy
regulations.
In
this
work,
we
address
problem
by
using
privacy-preserving
federated
learning-based
approach,
PriCell,
for
complex
such
as
convolutional
neural
networks.
PriCell
relies
on
multiparty
homomorphic
encryption
enables
collaborative
training
encrypted
networks
with
multiple
institutions.
We
preserve
confidentiality
each
institutions'
input
data,
any
intermediate
values,
trained
model
parameters.
efficiently
replicate
published
state-of-the-art
network
architecture
in
decentralized
manner.
Our
solution
achieves
an
accuracy
comparable
one
obtained
centralized
non-secure
solution.
guarantees
patient
ensures
utility
efficient
multi-center
studies
involving
data.