Association between SARS-CoV-2 viral load and serum biomarkers with mortality in Mexican patients DOI Creative Commons
Dulce Milagros Razo Blanco-Hernández, José Ángel Hernández-Mariano,

Mónica A. Díaz-Cureño

et al.

Journal of Education and Health Promotion, Journal Year: 2025, Volume and Issue: 14(1)

Published: March 1, 2025

BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has resulted in high mortality among hospitalized patients; thus, identifying markers treating these patients is essential. To evaluate the association between viral load and serum biomarkers with COVID-19. MATERIALS AND METHODS: A retrospective cohort study was conducted 198 inpatient records from a tertiary hospital Mexico City January April 2021. severe acute respiratory syndrome 2 (SARS-CoV-2) death due to COVID-19 assessed using Cox regression models. RESULTS: median age 54.9 years, 61.6% were males. rate 43.4%. After adjusting for potential confounders, higher [adjusted hazard ratio (aHR) = 1.56; 95% confidence interval (95% CI) 1.01, 2.42; P value 0.041]; concentrations of BUN (aHR 4.87;95% CI 2.70, 8.79; 0.001), creatinine 1.60;95% 2.54; 0.043), osmolality 4.37;95% 2.34, 8.14; glucose 2.41;95% 1.40, 4.18; 0.001) more likely have fatal prognosis. Conversely, risk lower lymphocytes 0.47;95% 0.30, 0.72; 0.001). CONCLUSION: SARS-CoV-2 such as BUN, creatinine, glucose, osmolarity, could help physicians identify individuals who require closer monitoring.

Language: Английский

Mortality and Years of Life Lost From Cardiometabolic Diseases in Mexico: National and State-Level Trends, 1998-2022 DOI
Marcela Agudelo‐Botero, Claudio Alberto Dávila-Cervantes

Public Health Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Cardiometabolic diseases (CMDs) are highly prevalent in Mexico. We analyzed the evolution of mortality from CMDs Mexico at national and state level, as well their contribution to years life lost (YLL), 1998 through 2022. conducted an observational study based on a public database. calculated age-standardized rates, joinpoint regression analyses determine changes trend magnitude over time, YLL among people nationally by state. From 2022, rate increased 14.9% These rates reached highest levels 2020 2021 during COVID-19 pandemic. In aged 0 84 had 3.9 CMDs, which represented increase 0.4 compared with 1998. for heart disease, diabetes mellitus, hypertension but decreased stroke. Mortality have steadily Mexico, driven mainly disease mellitus. attributable could be prevented early care health prevention policies. Decision makers should work implement robust enduring policies focused shared risk factors underlying these diseases.

Language: Английский

Citations

0

Association between SARS-CoV-2 viral load and serum biomarkers with mortality in Mexican patients DOI Creative Commons
Dulce Milagros Razo Blanco-Hernández, José Ángel Hernández-Mariano,

Mónica A. Díaz-Cureño

et al.

Journal of Education and Health Promotion, Journal Year: 2025, Volume and Issue: 14(1)

Published: March 1, 2025

BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has resulted in high mortality among hospitalized patients; thus, identifying markers treating these patients is essential. To evaluate the association between viral load and serum biomarkers with COVID-19. MATERIALS AND METHODS: A retrospective cohort study was conducted 198 inpatient records from a tertiary hospital Mexico City January April 2021. severe acute respiratory syndrome 2 (SARS-CoV-2) death due to COVID-19 assessed using Cox regression models. RESULTS: median age 54.9 years, 61.6% were males. rate 43.4%. After adjusting for potential confounders, higher [adjusted hazard ratio (aHR) = 1.56; 95% confidence interval (95% CI) 1.01, 2.42; P value 0.041]; concentrations of BUN (aHR 4.87;95% CI 2.70, 8.79; 0.001), creatinine 1.60;95% 2.54; 0.043), osmolality 4.37;95% 2.34, 8.14; glucose 2.41;95% 1.40, 4.18; 0.001) more likely have fatal prognosis. Conversely, risk lower lymphocytes 0.47;95% 0.30, 0.72; 0.001). CONCLUSION: SARS-CoV-2 such as BUN, creatinine, glucose, osmolarity, could help physicians identify individuals who require closer monitoring.

Language: Английский

Citations

0