Published: Jan. 1, 2024
Language: Английский
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155424 - 155424
Published: June 20, 2024
Language: Английский
Citations
11
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 8, 2025
Background: Environmental metal exposure has been implicated in the development of digestive tract cancers, although specific associations remain poorly defined. This study aimed to investigate relationship between blood levels and risk cancers among U.S. adults. Methods: Data from National Health Nutrition Examination Survey (NHANES) 2011–2018, including 13,467 participants aged 20 years older, were analyzed. Nine metals measured. Multivariable logistic regression, restricted cubic spline models, subgroup analyses employed assess cancer risk. Additionally, a Random Forest (RF) model was used for prediction. Results: Among participants, 9 had esophagus (EC), 11 gastric (GC), 83 colorectal (CRC). Compared healthy controls, EC patients exhibited significantly higher potassium (K, 4.40 vs. 4.00 mmol/L), cadmium (Cd, 12.46 2.49 µg/L), lead (Pb, 0.09 0.05 µg/L). GC elevated Pb (0.08 while CRC showed concentrations Cd (3.11 µg/L) (0.06 0.04 Logistic regression analysis revealed significant K (odds ratio [OR] = 7.58, 95% CI: 3.48–16.48, P < 0.0001), (OR 1.06, 1.04–1.08, 7.60, 3.26–17.72, 0.0001) also associated with 5.26, 2.11–13.10, 0.001). The RF an accuracy 76% predicting risk, SHapley Additive exPlanations (SHAP) highlighting iron (Fe) as key contributors. Conclusions: reveals positive association certain suggesting that limiting these may serve potential preventive measure.
Language: Английский
Citations
1
BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)
Published: Aug. 1, 2024
Many studies have investigated the role of metals in various types malignancies. Considering wide range conducted this field and achievement different results, presented systematic review was performed to obtain results investigations on prevention occurrence cancer associated with metal exposures. In review, research three databases: Scopus, PubMed, Web Science without historical restrictions until May 31, 2024. Animal studies, books, articles, conference papers, letters editors were omitted. The special checklist Joanna Briggs Institute (JBI) used for quality assessment articles. Finally, findings classified according effect as preventive or carcinogenic. total number retrieved articles 4695, 71 eligible further investigation. most concentration toxic such lead (Pb), chromium (Cr (VI)), arsenic (As), cadmium (Cd), nickel (Ni) biological clinical samples patients higher than that healthy people. addition, presence essential elements, selenium (Se), zinc (Zn), iron (Fe), manganese (Mn) tolerable low concentrations revealed anti-cancer properties, while exposure high has detrimental health effects. Metals carcinogenic effects at levels exposure. Taking measures, implementing timely screening, reducing emission metal-associated pollutants can play an effective rates around world.
Language: Английский
Citations
8
Breast Cancer Research, Journal Year: 2024, Volume and Issue: 26(1)
Published: July 8, 2024
Abstract The protein Bcl-2, well-known for its anti-apoptotic properties, has been implicated in cancer pathogenesis. Identifying the primary gene responsible promoting improved cell survival and development provided compelling evidence preventing cellular death progression of malignancies. Numerous research studies have that abundance Bcl-2 is higher malignant cells, suggesting suppressing expression could be a viable therapeutic approach treatment. In this study, we acquired compound collection using database includes constituents from Traditional Chinese Medicine (TCM). Initially, established pharmacophore model utilized it to search TCM potential compounds. Compounds with fitness score exceeding 0.75 were selected further analysis. Absorption, Distribution, Metabolism, Excretion, Toxicity (ADMET) analysis identified six compounds favorable characteristics. successfully passed initial screening process based on pharmacodynamic subjected evaluation. Extra-precision (XP) docking was employed identify most XP scores. Further Molecular Mechanics Generalized Born Surface Area (MM-GBSA) method calculate overall free binding energy. energy between prospective ligand molecule target assessed by 100 ns molecular dynamics simulation curcumin Epigallocatechin gallate (EGCG). findings investigation demonstrate identification structure effectively inhibits functionality when bound EGCG. Consequently, finding presents novel avenue pharmaceuticals capable addressing both inflammatory tumorous conditions.
Language: Английский
Citations
7
Toxics, Journal Year: 2024, Volume and Issue: 12(9), P. 632 - 632
Published: Aug. 28, 2024
Thyroid cancer rates have risen globally over the past four decades, with Puerto Rico experiencing a particularly pronounced increase. This may be linked to higher metal exposure, as some metals are endocrine disruptors and carcinogens. Currently, certain regions of Superfund programs because high concentrations in soil. Therefore, we investigated association between thyroid incidence three (lead, cadmium, mercury) known endocrine-disrupting properties increased levels soil samples Rico. We used National Health Nutrition Examination Survey (NHANES) data for heavy thyroglobulin antibody (TgAb) marker. Additionally, performed an ecological study using from Environmental Protection Agency (EPA) report on Metals Natural Anthropogenic Sources Soils Central Cancer Registry age-adjusted 2015 2019. Through NHANES analysis, found significant negative mercury TgAb. our study, observed northern parts Our heterogenous results necessitate further research this topic.
Language: Английский
Citations
0
Published: Jan. 1, 2024
Language: Английский
Citations
0