International Journal of Pharmaceutical Sciences and Drug Research, Journal Year: 2024, Volume and Issue: unknown, P. 586 - 591
Published: July 30, 2024
Liver cancer, particularly hepatocellular carcinoma (HCC), occurs from liver cell abnormalities, influenced by factors such viral hepatitis, obesity toxins and drugs. Non-Alcoholic Fatty Disease (NAFLD) exacerbates disorders globally, marked fat accumulation, whereas fibrosis raises cancer risk in NAFLD Alcohol-Induced (ALD). Herbal medicine gains attraction for health, offering hepatoprotective benefits. Medicinal plant metabolites, polyphenols, display antioxidative effects, possibly suppressing development. This work focuses on evaluating the possible antioxidant cytotoxic effects of Chrozophora rottleri fruit ethanol extract (CRFEE) using in-vitro experiments. The capacity CRFEE was examined hydroxyl radical nitric oxide scavenging revealed considerable efficacy against both radicals, radicals 48.25% with an IC50 35.08±1.62 μg/ml 49.35% 307.44±2.28 μg/ml. Notably, displayed better efficiency compared to standard antioxidant, butylated toluene (BHT), neutralizing radicals. Additionally, cytotoxicity MTT test HepG-2 line cultures. had strong detrimental cells, higher dosages resulting a major loss viability. value determined 63±0.08μg/mL, suggesting its reducing proliferation. results demonstrate substantial activity cells (HepG-2 line). bioactive chemicals contained show potential future pharmaceutical applications, underscoring relevance natural-based research therapy necessity further exploration vivo.
Language: Английский