Nanotechnology-Based Approaches for the Management of Diabetes Mellitus: An Innovative Solution to Long-Lasting Challenges in Antidiabetic Drug Delivery DOI Creative Commons
Shounak Sarkhel, Sohul Shuvo,

Md Ahesan Ansari

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1572 - 1572

Published: Dec. 9, 2024

Diabetes is a widespread metabolic illness. Mismanagement of diabetes can lead to severe complications that tremendously impact patients’ quality life. The assimilation nanotechnology in care holds the potential revolutionize treatment paradigms, improve patient outcomes, and reduce economic burden associated with this pervasive disease. This manuscript explores multifaceted utilization nanomaterials care, emphasizing unique features nano-based medication delivery methods smart drug mechanisms. Additionally, paper talks about research on nanocarrier-integrated oral, transdermal, inhalable insulin delivery; dendrimer- nanocarrier-coupled antisense oligonucleotide-driven gene therapy; implementation gold nanoparticles quantum dots for glucose surveillance; nucleic acid therapies. There are certain restrictions when using commonly available handle diabetes. In order increase efficacy safety, rapidly developing science also being explored employed medical biology. Nanomaterials like liposomes, dendrimers, niosomes, polymeric metallic nanocarriers, solid lipid among nanocarriers have been developed better various oral hypoglycemic agents comparison conventional These provide great control over elevated blood levels, making them one most intriguing promising technologies today. Furthermore, adding additional ligands allows more focused distribution while protecting encapsulated drugs.

Language: Английский

Green synthesis, characterization, antidiabetic, antioxidant and antibacterial applications of silver nanoparticles from Syzygium caryophyllatum (L.) Alston leaves DOI
Santosh Mallikarjun Bhavi, Bothe Thokchom, Megha B. Abbigeri

et al.

Process Biochemistry, Journal Year: 2024, Volume and Issue: 145, P. 89 - 103

Published: June 17, 2024

Language: Английский

Citations

17
Antioxidant and anti-diabetic potential of the green synthesized silver nanoparticles using Martynia annua L. root extract DOI Creative Commons
Megha B. Abbigeri, Bothe Thokchom, Sapam Riches Singh

et al.

Nano TransMed, Journal Year: 2025, Volume and Issue: unknown, P. 100070 - 100070

Published: Jan. 1, 2025

Language: Английский

Citations

4
Syzygium malaccense leaf extract-mediated silver nanoparticles: synthesis, characterization, and biomedical evaluation in Caenorhabditis elegans and lung cancer cell line DOI Creative Commons
Santosh Mallikarjun Bhavi, Bothe Thokchom, Sapam Riches Singh

et al.

Green Chemistry Letters and Reviews, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 30, 2025

The study explores the green synthesis and characterization of silver nanoparticles using Syzygium malaccense (L.) Merr. & L. M. Perry leaf extract (SM-AgNPs). UV-Visible spectroscopy confirmed reduction ions, showing an absorption peak at 406 nm. X-ray Diffraction (XRD) analysis revealed a face centered cubic structure with average particle size 23.55 Dynamic Light Scattering (DLS) zeta potential analyses indicated mean 40.1 nm surface charge −40.1 mV. FTIR identified functional groups involved in nanoparticle stabilization, while Energy Dispersive (EDX) content. Transmission Electron Microscopy (TEM) Atomic Force (AFM) provided detailed insights into morphology. Anticancer assays showed dose-dependent cytotoxicity against A549 cancer cells (LC50: 7.62 μg mL−1) minimal effects on L-132 normal 73.55 mL−1), highlighting selectivity. Additionally, SM-AgNPs increased Caenorhabditis elegans survival reduced paralysis under pathogenic bacterial exposure. This demonstrates biomedical applications, emphasizing selective anticancer activity antimicrobial vivo.

Language: Английский

Citations

2
Biogenic silver nanoparticles from Simarouba glauca DC leaf extract: Synthesis, characterization, and anticancer efficacy in lung cancer cells with protective effects in Caenorhabditis elegans DOI Creative Commons
Santosh Mallikarjun Bhavi,

Akshata Choudhari Padti,

Bothe Thokchom

et al.

Nano TransMed, Journal Year: 2024, Volume and Issue: unknown, P. 100052 - 100052

Published: Oct. 1, 2024

Language: Английский

Citations

8
The effect of Clitoria ternatea L. flowers-derived silver nanoparticles on A549 and L-132 human cell lines and their antibacterial efficacy in Caenorhabditis elegans in vivo DOI Creative Commons
Sapam Riches Singh,

Bushrabanu Kittur,

Santosh Mallikarjun Bhavi

et al.

Hybrid Advances, Journal Year: 2024, Volume and Issue: unknown, P. 100359 - 100359

Published: Dec. 1, 2024

Language: Английский

Citations

5
Nanoparticle Interactions with the Blood Brain Barrier: Insights from Drosophila and Implications for Human Astrocyte Targeted Therapies DOI Creative Commons

Akshata Choudhari Padti,

Santosh Mallikarjun Bhavi, Bothe Thokchom

et al.

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(1)

Published: Jan. 20, 2025

Language: Английский

Citations

0
Design, Synthesis, and Application of Modified Linear Peptides as Potential Antidiabetic Agent DOI

Realy Behery,

Silvère Augustin Soavina,

Indrianasolo

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141970 - 141970

Published: March 1, 2025

Language: Английский

Citations

0
Nanotechnology-Based Approaches for the Management of Diabetes Mellitus: An Innovative Solution to Long-Lasting Challenges in Antidiabetic Drug Delivery DOI Creative Commons
Shounak Sarkhel, Sohul Shuvo,

Md Ahesan Ansari

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1572 - 1572

Published: Dec. 9, 2024

Diabetes is a widespread metabolic illness. Mismanagement of diabetes can lead to severe complications that tremendously impact patients’ quality life. The assimilation nanotechnology in care holds the potential revolutionize treatment paradigms, improve patient outcomes, and reduce economic burden associated with this pervasive disease. This manuscript explores multifaceted utilization nanomaterials care, emphasizing unique features nano-based medication delivery methods smart drug mechanisms. Additionally, paper talks about research on nanocarrier-integrated oral, transdermal, inhalable insulin delivery; dendrimer- nanocarrier-coupled antisense oligonucleotide-driven gene therapy; implementation gold nanoparticles quantum dots for glucose surveillance; nucleic acid therapies. There are certain restrictions when using commonly available handle diabetes. In order increase efficacy safety, rapidly developing science also being explored employed medical biology. Nanomaterials like liposomes, dendrimers, niosomes, polymeric metallic nanocarriers, solid lipid among nanocarriers have been developed better various oral hypoglycemic agents comparison conventional These provide great control over elevated blood levels, making them one most intriguing promising technologies today. Furthermore, adding additional ligands allows more focused distribution while protecting encapsulated drugs.

Language: Английский

Citations

2