Ru(II)-Catalyzed C(sp2)–H Activation Annulation: Synthesis of Fluorescent Benzoisoquinolonyl Acetate/Peptides from N-Arylamides and Ethyne at Room Temperature DOI Creative Commons
Nagendra K. Sharma, Manish K. Gupta,

Ankita Panda

et al.

Published: Dec. 20, 2023

Benzoisoquinolones are aryl ring extended isoquinolinone derivatives, constituents of alkaloid natural products. This report describes the synthesis benzoisoquinolones amino acids/peptides derivatives from respective N-aryl esters /peptides through Ru-catalyzed C(sp2)–H annulation at room temperature. Herein, acid ester/amide residue acts as a directing group for ring, and then cyclization occurs amide NH. Importantly, these benzoisoquinolinones exhibit fluorescence in protic polar solvents. Hence, this methodology could be helpful to transform standard ac-ids/peptides into fluobenzoisoquinolinones conjugated fluorescent peptide temperature, which applicable leveling acid/peptides effectively.

Language: Английский

Ru(II)-Catalyzed C(sp2)–H Activation Annulation: Synthesis of Fluorescent Benzoisoquinolonyl Acetate/Peptides from N-Arylamides and Ethyne at Room Temperature DOI Creative Commons
Nagendra K. Sharma, Manish K. Gupta,

Ankita Panda

et al.

Published: Dec. 20, 2023

Benzoisoquinolones are aryl ring extended isoquinolinone derivatives, constituents of alkaloid natural products. This report describes the synthesis benzoisoquinolones amino acids/peptides derivatives from respective N-aryl esters /peptides through Ru-catalyzed C(sp2)–H annulation at room temperature. Herein, acid ester/amide residue acts as a directing group for ring, and then cyclization occurs amide NH. Importantly, these benzoisoquinolinones exhibit fluorescence in protic polar solvents. Hence, this methodology could be helpful to transform standard ac-ids/peptides into fluobenzoisoquinolinones conjugated fluorescent peptide temperature, which applicable leveling acid/peptides effectively.

Language: Английский

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