Assembly line library synthesis in flow: A multistep and multivectorial approach DOI Creative Commons
Brenda Pijper, Irini Abdiaj,

Javier Mazuela

et al.

Published: June 11, 2024

In drug discovery, traditional automated library synthesis has typically involved single-step synthetic procedures targeting a single vector of interest. However, achieving greater structural diversity requires exploring multistep and multivectorial approaches. These methodologies enable the preparation compounds with varying structures in experiment. Here, we present novel method for continuous flow. This approach offers unique opportunities, such as linkers between two defined vectors or rapidly mapping synergistic structure-activity relationship (SAR) by concurrently multiple vectors. Our incorporates up to eight different methodologies, including established chemistries, metal-catalysed transformations, modern metallaphotoredox couplings. broad range ensures high level generated, providing powerful tool accelerate exploration chemical space discovery programs.

Language: Английский

Assembly line library synthesis in flow: A multistep and multivectorial approach DOI Creative Commons
Brenda Pijper, Irini Abdiaj,

Javier Mazuela

et al.

Published: June 11, 2024

In drug discovery, traditional automated library synthesis has typically involved single-step synthetic procedures targeting a single vector of interest. However, achieving greater structural diversity requires exploring multistep and multivectorial approaches. These methodologies enable the preparation compounds with varying structures in experiment. Here, we present novel method for continuous flow. This approach offers unique opportunities, such as linkers between two defined vectors or rapidly mapping synergistic structure-activity relationship (SAR) by concurrently multiple vectors. Our incorporates up to eight different methodologies, including established chemistries, metal-catalysed transformations, modern metallaphotoredox couplings. broad range ensures high level generated, providing powerful tool accelerate exploration chemical space discovery programs.

Language: Английский

Citations

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