Published: April 2, 2024

In the last decades, numerous efforts have been made to replace metal catalysts with cheaper and earth-abundant alternatives or complete exclusion of metals in cross-coupling reactions, maintaining high efficiency target transformation. However, follow-up studies often revealed role impurities catalytic process. Thus, active lead mechanistic misinterpretations, could initiate erroneous research directives, can severe reproducibility problems. Milestone precedents impurity effect reactions are well documented literature. Interestingly, this fallacy has occurred repeatedly over years due lack thorough appropriate study scheme for identifying effect. Herein, we propose a guideline elucidating real catalyst future transformations that eliminate misinterpretation help exclude novel processes. Although mainly focuses on problems related trace transition metals, it also offers base more general research.

Language: Английский