Transducing chemical energy through catalysis by an artificial molecular motor DOI Creative Commons
Peng-Lai Wang, Stefan Borsley, M. Power

et al.

Published: May 24, 2024

Cells display a range of mechanical activities enabled by the cytoskeleton, viscoelastic hydrogel manipulated motor proteins powered through catalysis. This raises question how acceleration chemical reaction can enable energy released from that to be transduced, and thereby work done, molecular catalyst. Here we demonstrate molecular-level transduction force in form contraction re-expansion crosslinked polymer gel driven directional rotation embedded artificial catalysis-driven motors. Continuous 360° rotor about stator motor-molecules incorporated within polymeric framework gel, twists chains network around one another (either clockwise or anti-clockwise, depending on chirality fuelling system). progressively increases writhe tightens entanglements, causing macroscopic ~70% its original volume. The limit corresponds stall motor; point at which, despite catalysis continuing, untwisting exerted entwined strands balances conformation selection motor’s catalytic cycle. Subsequent addition opposite enantiomeric system powers contracted reverse direction, unwinding entanglements re-expand. Continued twisting new direction causes contract once again. experimental demonstration against load synthetic catalyst, mechanism catalyst kinetic asymmetry fuel-to-waste reaction, informs both debate surrounding generation biological motors design principles for nanotechnology.

Language: Английский

Transducing chemical energy through catalysis by an artificial molecular motor DOI Creative Commons
Peng-Lai Wang, Stefan Borsley, M. Power

et al.

Published: May 24, 2024

Cells display a range of mechanical activities enabled by the cytoskeleton, viscoelastic hydrogel manipulated motor proteins powered through catalysis. This raises question how acceleration chemical reaction can enable energy released from that to be transduced, and thereby work done, molecular catalyst. Here we demonstrate molecular-level transduction force in form contraction re-expansion crosslinked polymer gel driven directional rotation embedded artificial catalysis-driven motors. Continuous 360° rotor about stator motor-molecules incorporated within polymeric framework gel, twists chains network around one another (either clockwise or anti-clockwise, depending on chirality fuelling system). progressively increases writhe tightens entanglements, causing macroscopic ~70% its original volume. The limit corresponds stall motor; point at which, despite catalysis continuing, untwisting exerted entwined strands balances conformation selection motor’s catalytic cycle. Subsequent addition opposite enantiomeric system powers contracted reverse direction, unwinding entanglements re-expand. Continued twisting new direction causes contract once again. experimental demonstration against load synthetic catalyst, mechanism catalyst kinetic asymmetry fuel-to-waste reaction, informs both debate surrounding generation biological motors design principles for nanotechnology.

Language: Английский

Citations

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