Published: May 10, 2024
The synthesis of complex polysubstituted aromatic molecules from simple precursors is a central goal in organic chemistry. In this study, we developed an approach for the ortho-alkylation iodoarenes utilizing dual ligand catalytic system. By combining Pd/olefin cooperative catalysis with bulky trialkylphosphine ligand-promoted C(sp2)-I reductive elimination, have established ortho-alkylative Catellani-type reaction aryl-iodine bond reconstruction as final step, which opens new synthetic opportunities within reactions. Through in-depth mechanistic investigations, isolated and characterized key organopalladium intermediates, revealing synergistic interaction ligands merging process elimination. present study showcases unique advantages emphasizes effectiveness system expanding chemical space Catellani
Language: Английский