Grouping strategies for assessing and managing persistent and mobile substances DOI Creative Commons
Parviel Chirsir, Emma Palm, Sivani Baskaran

et al.

Published: March 28, 2024

Background: Persistent, Mobile and Toxic (PMT), or very Persistent (vPvM) substances are a wide class of chemicals that recalcitrant to degradation, easily transported, potentially harmful humans the environment. Due their persistence mobility, these often widespread in environment once emitted, particularly water resources, causing increased challenges during treatment processes. Some PMT/vPvM such as GenX perfluorobutane sulfonic acid have been identified high concern (SVHCs) under European Registration, Evaluation, Authorisation Restriction Chemicals (REACH) regulation. With hundreds thousands potential yet be assessed managed, effective efficient approaches avoid case-by-case assessment prevent regrettable substitution necessary achieve Union's zero-pollution goal for non-toxic by 2050. Main: Substance grouping has helped global regulation some highly hazardous chemicals, e.g., through Montreal Protocol Stockholm Convention. This article explores strategies identifying, assessing managing substances. The aim is facilitate early identification lesser-known new meet criteria, prompt additional testing, use substitution, integrate into existing risk management strategies. Thus, this provides an overview reviews definition criteria various lists available. It covers current groups, compares substance hazard regulation, discusses advantages disadvantages then substances, including read-across, structural similarity commonly retained moieties, well application using cheminformatics predict P, M T properties selected examples. Conclusion: Effective can accelerate especially lack information. Advances read-across methods tools needed support chemical management, preventing broad entry market favouring safer more sustainable alternatives.

Language: Английский

Grouping strategies for assessing and managing persistent and mobile substances DOI Creative Commons
Parviel Chirsir, Emma Palm, Sivani Baskaran

et al.

Published: March 28, 2024

Background: Persistent, Mobile and Toxic (PMT), or very Persistent (vPvM) substances are a wide class of chemicals that recalcitrant to degradation, easily transported, potentially harmful humans the environment. Due their persistence mobility, these often widespread in environment once emitted, particularly water resources, causing increased challenges during treatment processes. Some PMT/vPvM such as GenX perfluorobutane sulfonic acid have been identified high concern (SVHCs) under European Registration, Evaluation, Authorisation Restriction Chemicals (REACH) regulation. With hundreds thousands potential yet be assessed managed, effective efficient approaches avoid case-by-case assessment prevent regrettable substitution necessary achieve Union's zero-pollution goal for non-toxic by 2050. Main: Substance grouping has helped global regulation some highly hazardous chemicals, e.g., through Montreal Protocol Stockholm Convention. This article explores strategies identifying, assessing managing substances. The aim is facilitate early identification lesser-known new meet criteria, prompt additional testing, use substitution, integrate into existing risk management strategies. Thus, this provides an overview reviews definition criteria various lists available. It covers current groups, compares substance hazard regulation, discusses advantages disadvantages then substances, including read-across, structural similarity commonly retained moieties, well application using cheminformatics predict P, M T properties selected examples. Conclusion: Effective can accelerate especially lack information. Advances read-across methods tools needed support chemical management, preventing broad entry market favouring safer more sustainable alternatives.

Language: Английский

Citations

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