A ligand-assisted proximity effect allows for H2-driven copper hy-dride chemistry under mild conditions DOI Creative Commons

Mahadeb Gorai,

Philipp Rotering,

J. Franzen

et al.

Published: Oct. 16, 2024

A bifunctional copper(I)/N-heterocyclic carbene complex bearing a highly basic 2-iminopyridine subunit effects variety of copper(I) hydride-based reductive transformations at low H2 pressure. The catalyst allows for the first time to employ only catalytic amounts alkoxide additive and is with highest reactivity towards re-ported so far. We can demonstrate that efficient alkyne semihydrogenations, conjugate reductions as well 1,2-reductions carbonyl compounds be carried out very new protocol circumvents need previously required high-pressure equipment. At same time, use iminopyridine-based ligand tolerance an unprecedented functional groups in realm copper(I)-catalyzed hydrogenations. possible working model featuring iminopyridine-mediated proximity effect coordinates key close reactive cop-per(I) center proposed account observed significant rise reactivity. Mechanistic studies directed support-ing this current hypothesis are presented.

Language: Английский

A ligand-assisted proximity effect allows for H2-driven copper hy-dride chemistry under mild conditions DOI Creative Commons

Mahadeb Gorai,

Philipp Rotering,

J. Franzen

et al.

Published: Oct. 16, 2024

A bifunctional copper(I)/N-heterocyclic carbene complex bearing a highly basic 2-iminopyridine subunit effects variety of copper(I) hydride-based reductive transformations at low H2 pressure. The catalyst allows for the first time to employ only catalytic amounts alkoxide additive and is with highest reactivity towards re-ported so far. We can demonstrate that efficient alkyne semihydrogenations, conjugate reductions as well 1,2-reductions carbonyl compounds be carried out very new protocol circumvents need previously required high-pressure equipment. At same time, use iminopyridine-based ligand tolerance an unprecedented functional groups in realm copper(I)-catalyzed hydrogenations. possible working model featuring iminopyridine-mediated proximity effect coordinates key close reactive cop-per(I) center proposed account observed significant rise reactivity. Mechanistic studies directed support-ing this current hypothesis are presented.

Language: Английский

Citations

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