Aging device: tau protein transposes the telomere fragment into promoter/enhancer to promote gene copy number decrement regulation DOI Creative Commons
Wenzhong Liu,

Li hualan

Published: Aug. 2, 2024

The reasons for the significant impact of abnormal tau protein phosphorylation and aggregation on Alzheimer's disease are still unknown. This study used bioinformatics methods, including domain search tools, to investigate pathogenic mechanism in neurodegenerative diseases. reveals that possesses domains linked Aging Device. These include pyruvate kinase, phosphatase, telomere binding, transposition, HNH cas9, replicon helicase, DNA polymerase, nuclease, transcription factors-like, promoter binding (TATA-box), enhancer (Homeobox, MADS-box, HMG box), mitochondrial localization mtDNA polymerase. It implies protein's kinase supplies ATP energy its Device function. Cas9 , reverse transcriptase, transposase cut sequence between "TAA" from then transcript guide RNA sequence. factor slides specific region. excises intron region complementary RAN nuclease splice or add fragment We thought transposes fragments promoter/enhancer might mess up polymerase II, which would help Device's telomere-guided gene (DNA nucleus mitochondrial) copy number decrement regulation system work better. can us understand how stress injuries, like low blood sugar oxygen levels, cause clump together phosphorylate, turns off a way doesn't make sense. Thus, anomalous aging devices, such as protein, may be associated with diseases Alzheimer disease, amyotrophic lateral sclerosis.

Language: Английский

Aging device: tau protein transposes the telomere fragment into promoter/enhancer to promote gene copy number decrement regulation DOI Creative Commons
Wenzhong Liu,

Li hualan

Published: Aug. 2, 2024

The reasons for the significant impact of abnormal tau protein phosphorylation and aggregation on Alzheimer's disease are still unknown. This study used bioinformatics methods, including domain search tools, to investigate pathogenic mechanism in neurodegenerative diseases. reveals that possesses domains linked Aging Device. These include pyruvate kinase, phosphatase, telomere binding, transposition, HNH cas9, replicon helicase, DNA polymerase, nuclease, transcription factors-like, promoter binding (TATA-box), enhancer (Homeobox, MADS-box, HMG box), mitochondrial localization mtDNA polymerase. It implies protein's kinase supplies ATP energy its Device function. Cas9 , reverse transcriptase, transposase cut sequence between "TAA" from then transcript guide RNA sequence. factor slides specific region. excises intron region complementary RAN nuclease splice or add fragment We thought transposes fragments promoter/enhancer might mess up polymerase II, which would help Device's telomere-guided gene (DNA nucleus mitochondrial) copy number decrement regulation system work better. can us understand how stress injuries, like low blood sugar oxygen levels, cause clump together phosphorylate, turns off a way doesn't make sense. Thus, anomalous aging devices, such as protein, may be associated with diseases Alzheimer disease, amyotrophic lateral sclerosis.

Language: Английский

Citations

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