Markovnikov Selective Hydroboration of Aryl Alkenes Catalyzed by Quaternary Ammonium Salts DOI Creative Commons
Paweł Huninik, Hoyoung Im, Jakub Szyling

et al.

Published: March 27, 2024

Despite recent advancements in the development of catalytic Markovnikov-selective hydroboration alkenes, metal-free procedure has long remained an unsolved challenge. Here, we report organocatalytic hy-droboration aryl alkenes using a commercially available quaternary ammonium catalyst. The method is operationally simple, scalable, and compatible with wide variety substrates it can be successfully applied synthesis active pharmaceutical ingredients (API) such as Chlorphenoxamine. Through in-depth experimental DFT studies, elucidate nuanced understanding mechanism regioselectivity this reaction.

Language: Английский

Markovnikov Selective Hydroboration of Aryl Alkenes Catalyzed by Quaternary Ammonium Salts DOI Creative Commons
Paweł Huninik, Hoyoung Im, Jakub Szyling

et al.

Published: March 27, 2024

Despite recent advancements in the development of catalytic Markovnikov-selective hydroboration alkenes, metal-free procedure has long remained an unsolved challenge. Here, we report organocatalytic hy-droboration aryl alkenes using a commercially available quaternary ammonium catalyst. The method is operationally simple, scalable, and compatible with wide variety substrates it can be successfully applied synthesis active pharmaceutical ingredients (API) such as Chlorphenoxamine. Through in-depth experimental DFT studies, elucidate nuanced understanding mechanism regioselectivity this reaction.

Language: Английский

Citations

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