Dynamics of oxidative stress markers and mental status in patients with post-COVID-19 asthenic syndrome: Effects of adjunctive systemic ozone therapy

Russian Open Medical Journal, Journal Year: 2025, Volume and Issue: 14(1)

Published: March 31, 2025

This study aimed to evaluate the effect of systemic ozone therapy, when used as an adjunct pharmacological treatment, on plasma levels malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), and measures mental status in patients with post-COVID-19 asthenic syndrome (PCAS). Material Methods — A total 140 patients, aged 18 45 years, (PCAS) were examined treated. These randomly divided into two groups: a main group (n=70) receiving therapy addition comparison only treatment. Pre- post-treatment outcomes assessed by measuring MDA, SOD, GPx, employing MFI-20, MoCA, ISI, HAM-A, CGI-S scales. Results Prior exhibited elevated insulin-like growth factor 1 (IGF-1) reduced neurotrophic factors (BDNF NGF) blood serum. Those treated resveratrol standard treatment showed more pronounced changes IGF-1, BDNF, NGF compared group, their approaching those control group. Based MoCA scale, significant improvement cognitive function. Conclusion Adjunctive combined resulted reduction oxidative stress among Notably, 95% experienced complete or near-complete resolution PCAS symptoms. findings suggest that may be effective pathogenetically relevant strategy for comprehensive outpatient management PCAS.

Language: Английский

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Effectiveness of enriching drug treatment with systemic ozone therapy in patients with post-COVID asthenic syndrome

Bulletin of Russian State Medical University, Journal Year: 2024, Volume and Issue: 2024(4)

Published: Aug. 1, 2024

Post-COVID asthenic syndrome (PCAS) is still the subject of active study. The study was aimed to assess effects systemic ozone therapy used complement drug on plasma levels TNFα, IL1β, IL6 and parameters mental status in patients with PCAS. Two randomized groups PCAS (n = 140, age 18–45) were assessed treated: index group 70) received addition therapy; comparison without therapy. Plasma measured patients’ using MFI-20, MoCa, ISI, HARS, CGI-S scores before after treatment. After end (on day 30) reported for showed no significant differences from values control (р > 0.05) lover, than by 39% 0.003), 33.3% 0.022), 36.1% 0.012), respectively. changes also more pronounced group, group: average final MFI-20 score lower 36.7% 0.001), ISI 50.5% < HARS 45.8% while MoCa higher 10.9% 0.046), In number “no disease” based 94.2%, it 62.9% 0.001). our adding allowed us achieve normalization complete reduction clinical manifestations 94.2% cases. Thus, use can be considered as one effective pathogenetically substantiated strategies combination treatment outpatient settings.

Language: Английский

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Effect of systemic ozone therapy added to pharmacological treatment on brain-derived neurotrophic factor (BDNF) and cognitive status in post-COVID patients

Russian Journal of Physiotherapy Balneology and Rehabilitation, Journal Year: 2024, Volume and Issue: 23(1), P. 57 - 67

Published: Nov. 20, 2024

BACKGROUND: Treatment is required for post-COVID cognitive impairment associated with functional limitations, reduced work capacity, and significant deterioration in quality of life. Pharmacological treatment ineffective. In this context, physical therapy, especially systemic ozone therapy potential neuroprotective effects, appears promising. AIM: The aim the study was to evaluate effect added pharmacological on plasma brain-derived neurotrophic factor (BDNF) levels status patients impairment. MATERIALS AND METHODS: A total 140 aged 18-45 years asthenic syndrome were evaluated treated. They randomized into two groups: an experimental group 70 subjects who received addition comparator only. Pre- post-treatment outcomes assessed using BDNF Montreal Cognitive Assessment (MoCa) score. RESULTS: Statistically differences (р=0.034) MoCa scores (р=0.002) found between compared groups at end (day 30). our study, adding normalized completely improved clinical manifestations 95% subjects. CONCLUSION: Therefore, can be considered as one effective pathogenetically proven strategies comprehensive outpatient setting.

Language: Английский

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ANÁLISE MULTIFATORIAL DA SÍNDROME PÓS-COVID-19: REVISÃO DAS MANIFESTAÇÕES CLÍNICAS E COMPLICAÇÕES PARA ESTRATÉGIAS DE PREVENÇÃO NAS UNIDADES BÁSICAS DE SAÚDE SOB O MODELO DE EWING

Revista Foco, Journal Year: 2024, Volume and Issue: 17(7), P. e5525 - e5525

Published: July 19, 2024

A síndrome pós-COVID-19, ou COVID Longa, surge como sequela da infecção pelo SARS-CoV-2, caracterizada por sintomas persistentes que impactam a qualidade de vida dos pacientes, fadiga, dispneia, dor torácica, arritmias, ansiedade e depressão. Até outubro 2023, o Brasil registrou mais 37 milhões casos confirmados, com uma taxa letalidade 1,9%. Organização Mundial Saúde (OMS) define essa condição quando os persistem três meses após inicial. Este estudo visa analisar as manifestações clínicas complicações Longa. Realizou-se revisão integrativa literatura nas bases dados PubMed Biblioteca Virtual em (BVS) entre maio junho 2024, utilizando descritores "Síndrome Pós-COVID-19" "Complicações". Foram incluídos artigos publicados 2021 inglês, focados ensaios clínicos testes controlados aleatórios, excluindo revisões literatura, estudos gestantes menores 18 anos, duplicados. Dez foram selecionados para análise. Os resultados indicam variedade persistentes, incluindo miocardite, ansiedade, depressão, comprometimento cognitivo, disfunção autonômica redução função pulmonar. pós-COVID-19 demanda estratégias prevenção primária reabilitação, abordagens multidisciplinares essenciais avaliação tratamento dessas complicações. continuidade pesquisa sobre efeitos longo prazo COVID-19 é fundamental desenvolvimento diretrizes eficazes, Unidades Básicas desempenhando um papel vital na recuperação conforme modelo Ewing.

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