The Counteracting Effect of Chrysin on Dietary Fructose-Induced Metabolic-Associated Fatty Liver Disease (MAFLD) in Rats with a Focus on Glucose and Lipid Metabolism

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 380 - 380

Published: Jan. 17, 2025

The prevalence of metabolic syndrome has been exponentially increasing in recent decades. Thus, there is an need for affordable and natural interventions this disorder. We explored the effect chrysin, a dietary polyphenol, on hepatic lipid glycogen accumulation, dysfunction-associated fatty liver disease (MAFLD) activity score oxidative stress adipose tissue metabolism rats presenting syndrome-associated conditions. Rats fed chow diet were separated into four groups: Control (tap water), Fructose water with 10% fructose), Chrysin water+ chrysin (100 mg/kg body weight/d)), + fructose weight/d, daily)) (for 18 weeks). When associated diet, reduced storage, increased antioxidant potential glutathione de novo lipogenesis tissue. high fructose-diet, attenuated increase improved MAFLD score, decreased peroxidation, glutathione, glucose markers In conclusion, our results suggest that beneficial addition to daily improvement health, particularly individuals suffering from syndrome.

Language: Английский

Delites™ supplementation prevents metabolic syndrome onset and modulates gut microbiome in male Sprague Dawley rats fed on cholesterol- and fat-enriched diet: a randomized preclinical trial study

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 22, 2025

Background Metabolic syndrome (MetS) is a global health concern, characterized by combination of dyslipidemia, insulin resistance, obesity, and hypertension, significantly increasing the risk type 2 diabetes mellitus (T2DM) cardiovascular diseases. Gut microbiota plays pivotal role in MetS pathophysiology, with dysbiosis exacerbating metabolic impairments. Delites™, supplement inspired Traditional Chinese Medicine, has shown potential modulating gut mitigating MetS. Objectives This study aimed to evaluate effects Delites™ supplementation on composition male Sprague Dawley rats fed cholesterol- fat-enriched diet (CFED). Methods A randomized preclinical trial was conducted 32 divided into four groups: control-normal, CFED, CFED+low-dose (54 mg/kg), CFED+high-dose (108 mg/kg). Parameters including lipid profiles, enzymatic activity, molecular biomarkers, were analyzed. Results improved reduced inflammation (TNF- α ), enhanced anti-inflammatory markers (IL-10), increased energy metabolism regulator PGC-1α. modulation showed beneficial genera ( Bifidobacterium , Lactobacillus ) pathogenic Proteus improving microbial diversity. Conclusion effectively mitigates through modulation. These findings highlight its for precision medicine approaches combat disorders. Further research needed explore long-term translational relevance humans.

Language: Английский