A New Insight into Phage Combination Therapeutic Approaches Against Drug-Resistant Mixed Bacterial Infections DOI Open Access

Mohammadreza Rahimian,

Davoud Jafari-Gharabaghlou, Elham Mohammadi

et al.

PHAGE, Journal Year: 2024, Volume and Issue: 5(4), P. 203 - 222

Published: Oct. 17, 2024

Rising antibiotic resistance among bacterial pathogens has become a substantial health issue for human civilization. The emergence of these in high-risk diseases such as cystic fibrosis (CF) led to financial and nonfinancial losses, necessitating alternative therapies. This study presents an overview approaches, including phage therapy, antimicrobial peptides (AMPs), nanotechnology, monoclonal antibodies (mAbs), microbial therapies (probiotic therapy), clustered regularly interspaced short palindromic repeats technology (CRISPR), aptamers focusing on their mechanisms action exploring the impact combining derivatives with mentioned approaches. Although approaches combinations phages show promise, phage-antibiotic combination been subject most studies, It proven be highly effective combating antibiotic-resistant infections. Other also appear promising, but further studies are needed determine effectiveness. emphasizes need more thorough research into different treatments beyond well-established strategy.

Language: Английский

Understanding the Mechanism of Microplastic-Associated Antibiotic Resistance Genes in Aquatic Ecosystems: Insights from Metagenomic Analyses and Machine Learning DOI
Tengyi Zhu, Shuyin Li,

Cuicui Tao

et al.

Water Research, Journal Year: 2024, Volume and Issue: 268, P. 122570 - 122570

Published: Oct. 2, 2024

Language: Английский

Citations

3
Tackling the Antimicrobial Resistance “Pandemic” with Machine Learning Tools: A Summary of Available Evidence DOI Creative Commons
Doris Rušić, Marko Kumrić, Ana Šešelja Perišin

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(5), P. 842 - 842

Published: April 23, 2024

Antimicrobial resistance is recognised as one of the top threats healthcare bound to face in future. There have been various attempts preserve efficacy existing antimicrobials, develop new and efficient manage infections with multi-drug resistant strains, improve patient outcomes, resulting a growing mass routinely available data, including electronic health records microbiological information that can be employed individualised antimicrobial stewardship. Machine learning methods developed predict from whole-genome sequencing forecast medication susceptibility, recognise epidemic patterns for surveillance purposes, or propose antibacterial treatments accelerate scientific discovery. Unfortunately, there an evident gap between number machine applications science effective implementation these systems. This narrative review highlights some outstanding opportunities offers when applied research related resistance. In future, tools may prove superbugs' kryptonite. aims provide overview publications aid researchers are looking expand their work approaches acquaint them current application techniques this field.

Language: Английский

Citations

3
A multi-channel electrochemical biosensor based on polyadenine tetrahedra for the detection of multiple drug resistance genes DOI

Yanan Song,

Jun Feng, Xueming Wang

et al.

The Analyst, Journal Year: 2024, Volume and Issue: 149(12), P. 3425 - 3432

Published: Jan. 1, 2024

PolyA-TDF enables PCR-free qualitative detection of drug-resistant genes, integrating biosensor recognition and probe immobilization via strong adsorption to gold.

Language: Английский

Citations

2
A New Insight into Phage Combination Therapeutic Approaches Against Drug-Resistant Mixed Bacterial Infections DOI Open Access

Mohammadreza Rahimian,

Davoud Jafari-Gharabaghlou, Elham Mohammadi

et al.

PHAGE, Journal Year: 2024, Volume and Issue: 5(4), P. 203 - 222

Published: Oct. 17, 2024

Rising antibiotic resistance among bacterial pathogens has become a substantial health issue for human civilization. The emergence of these in high-risk diseases such as cystic fibrosis (CF) led to financial and nonfinancial losses, necessitating alternative therapies. This study presents an overview approaches, including phage therapy, antimicrobial peptides (AMPs), nanotechnology, monoclonal antibodies (mAbs), microbial therapies (probiotic therapy), clustered regularly interspaced short palindromic repeats technology (CRISPR), aptamers focusing on their mechanisms action exploring the impact combining derivatives with mentioned approaches. Although approaches combinations phages show promise, phage-antibiotic combination been subject most studies, It proven be highly effective combating antibiotic-resistant infections. Other also appear promising, but further studies are needed determine effectiveness. emphasizes need more thorough research into different treatments beyond well-established strategy.

Language: Английский

Citations

2